======= KCNJ10 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KCNJ10
  * **<color #00a2e8>Official Name</color>**: potassium inwardly rectifying channel subfamily J member 10
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3766|3766]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P78508|P78508]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KCNJ10&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KCNJ10|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602208|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the inward rectifier-type potassium channel family, characterized by having a greater tendency to allow potassium to flow into, rather than out of, a cell. The encoded protein may form a heterodimer with another potassium channel protein and may be responsible for the potassium buffering action of glial cells in the brain. Mutations in this gene have been associated with seizure susceptibility of common idiopathic generalized epilepsy syndromes. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May be responsible for potassium buffering action of glial cells in the brain. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium (By similarity). In the kidney, together with KCNJ16, mediates basolateral K(+) recycling in distal tubules; this process is critical for Na(+) reabsorption at the tubules. {ECO:0000250, ECO:0000305|PubMed:24561201}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|IRK|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|glutamate reuptake|
|amino acid neurotransmitter reuptake|
|ATP-activated inward rectifier potassium channel activity|
|L-glutamate import across plasma membrane|
|regulation of resting membrane potential|
|L-glutamate import|
|neurotransmitter reuptake|
|amino acid import across plasma membrane|
|L-glutamate transmembrane transport|
|central nervous system myelination|
|inward rectifier potassium channel activity|
|axon ensheathment in central nervous system|
|amino acid import|
|regulation of long-term neuronal synaptic plasticity|
|potassium ion homeostasis|
|neurotransmitter uptake|
|adult walking behavior|
|walking behavior|
|oligodendrocyte development|
|potassium ion import across plasma membrane|
|L-alpha-amino acid transmembrane transport|
|acidic amino acid transport|
|regulation of neuronal synaptic plasticity|
|L-amino acid transport|
|oligodendrocyte differentiation|
|drug transmembrane transport|
|inorganic ion import across plasma membrane|
|inorganic cation import across plasma membrane|
|amino acid transmembrane transport|
|adult locomotory behavior|
|dicarboxylic acid transport|
|presynapse|
|import across plasma membrane|
|myelination|
|glial cell development|
|ensheathment of neurons|
|axon ensheathment|
|amino acid transport|
|organic acid transmembrane transport|
|carboxylic acid transmembrane transport|
|monovalent inorganic cation homeostasis|
|adult behavior|
|drug transport|
|potassium ion transmembrane transport|
|potassium ion transport|
|glial cell differentiation|
|neurotransmitter transport|
|regulation of synaptic plasticity|
|locomotory behavior|
|basolateral plasma membrane|
|gliogenesis|
|visual perception|
|sensory perception of light stimulus|
|anion transmembrane transport|
|carboxylic acid transport|
|organic acid transport|
|regulation of neurotransmitter levels|
|monovalent inorganic cation transport|
|regulation of membrane potential|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|organic anion transport|
|regulation of ion transmembrane transport|
|inorganic cation transmembrane transport|
|regulation of transmembrane transport|
|behavior|
|anion transport|
|cation transmembrane transport|
|metal ion homeostasis|
|metal ion transport|
|inorganic ion transmembrane transport|
|import into cell|
|regulation of ion transport|
|cation homeostasis|
|inorganic ion homeostasis|
|ion homeostasis|
|cation transport|
|ion transmembrane transport|
|sensory perception|
|central nervous system development|
|response to drug|
|chemical homeostasis|
|transmembrane transport|
|ion transport|
|nervous system process|
|integral component of plasma membrane|
|ATP binding|
|neurogenesis|
|homeostatic process|
|cell development|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp19|Etoposide 1μM R00 exp19]]|-1.7|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|2.03|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4447
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.38 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KCNJ10 Expression in NALM6 Cells: 0.38'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>