======= KCTD17 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KCTD17
  * **<color #00a2e8>Official Name</color>**: potassium channel tetramerization domain containing 17
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=79734|79734]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8N5Z5|Q8N5Z5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KCTD17&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KCTD17|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616386|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein that belongs to a conserved family of potassium channel tetramerization domain (KCTD)-containing proteins. The encoded protein functions in ciliogenesis by acting as a substrate adaptor for the cullin3-based ubiquitin-conjugating enzyme E3 ligase, and targets trichoplein, a keratin-binding protein, for degradation via polyubiquitinylation. A mutation in this gene is associated with autosomal dominant myoclonic dystonia 26. [provided by RefSeq, Nov 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Is a positive regulator of ciliogenesis, playing a crucial role in the initial steps of axoneme extension. It acts as a substrate-adapter for CUL3-RING ubiquitin ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of TCHP, a protein involved in ciliogenesis down-regulation (PubMed:25270598). May be involved in endoplasmic reticulum calcium ion homeostasis (PubMed:25983243). {ECO:0000269|PubMed:25270598, ECO:0000269|PubMed:25983243}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|K tetra|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cullin family protein binding|
|endoplasmic reticulum calcium ion homeostasis|
|positive regulation of cilium assembly|
|Cul3-RING ubiquitin ligase complex|
|positive regulation of organelle assembly|
|regulation of cilium assembly|
|positive regulation of plasma membrane bounded cell projection assembly|
|regulation of plasma membrane bounded cell projection assembly|
|regulation of cell projection assembly|
|regulation of organelle assembly|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|protein homooligomerization|
|proteasomal protein catabolic process|
|positive regulation of cell projection organization|
|cellular calcium ion homeostasis|
|calcium ion homeostasis|
|cellular divalent inorganic cation homeostasis|
|divalent inorganic cation homeostasis|
|protein complex oligomerization|
|positive regulation of cellular component biogenesis|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|cellular metal ion homeostasis|
|proteolysis involved in cellular protein catabolic process|
|cellular protein catabolic process|
|positive regulation of organelle organization|
|metal ion homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|protein catabolic process|
|regulation of plasma membrane bounded cell projection organization|
|cation homeostasis|
|regulation of cell projection organization|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|ion homeostasis|
|cellular homeostasis|
|cellular macromolecule catabolic process|
|regulation of cellular component biogenesis|
|endoplasmic reticulum|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|identical protein binding|
|chemical homeostasis|
|cell projection organization|
|positive regulation of cellular component organization|
|proteolysis|
|regulation of organelle organization|
|protein-containing complex assembly|
|homeostatic process|
|organic substance catabolic process|
|cellular catabolic process|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|-1.75|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|-1.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.599|
|[[:human genes:c:chd4|CHD4]]|0.583|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.567|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.561|
|[[:human genes:t:twistnb|TWISTNB]]|0.559|
|[[:human genes:d:ddtl|DDTL]]|0.558|
|[[:human genes:v:vasn|VASN]]|0.557|
|[[:human genes:c:cbwd3|CBWD3]]|0.548|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.545|
|[[:human genes:p:psmb4|PSMB4]]|0.544|
|[[:human genes:a:akirin2|AKIRIN2]]|0.544|
|[[:human genes:c:cbwd5|CBWD5]]|0.543|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.542|
|[[:human genes:p:psma6|PSMA6]]|0.541|
|[[:human genes:p:psma7|PSMA7]]|0.535|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.532|
|[[:human genes:t:tceb3c|TCEB3C]]|0.532|
|[[:human genes:r:rps19bp1|RPS19BP1]]|0.532|
|[[:human genes:p:pan3|PAN3]]|0.531|
|[[:human genes:c:copg1|COPG1]]|0.53|
|[[:human genes:p:psmb1|PSMB1]]|0.523|
|[[:human genes:p:psmd1|PSMD1]]|0.522|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.52|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.516|
|[[:human genes:c:cbwd6|CBWD6]]|0.515|
|[[:human genes:t:tp53tg3|TP53TG3]]|0.515|
|[[:human genes:t:tp53tg3b|TP53TG3B]]|0.515|
|[[:human genes:o:orc1|ORC1]]|0.515|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.514|
|[[:human genes:t:tp53tg3c|TP53TG3C]]|0.514|
|[[:human genes:a:ankle2|ANKLE2]]|0.513|
|[[:human genes:t:tfip11|TFIP11]]|0.512|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.512|
|[[:human genes:r:rps12|RPS12]]|0.511|
|[[:human genes:r:rps2|RPS2]]|0.51|
|[[:human genes:b:bysl|BYSL]]|0.506|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.502|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.502|
|[[:human genes:d:dnttip2|DNTTIP2]]|0.502|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.502|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.502|
|[[:human genes:t:terf2|TERF2]]|0.502|
|[[:human genes:s:ssh2|SSH2]]|0.5|
|[[:human genes:t:ticrr|TICRR]]|0.499|
|[[:human genes:o:orc6|ORC6]]|0.499|
|[[:human genes:n:nupl1|NUPL1]]|0.498|
|[[:human genes:e:exosc4|EXOSC4]]|0.496|
|[[:human genes:i:ints5|INTS5]]|0.494|
|[[:human genes:r:rbbp5|RBBP5]]|0.493|
|[[:human genes:t:tsg101|TSG101]]|0.492|
|[[:human genes:h:hap1|HAP1]]|0.491|
|[[:human genes:s:sap30bp|SAP30BP]]|0.491|
|[[:human genes:d:dtl|DTL]]|0.49|
|[[:human genes:c:cactin|CACTIN]]|0.49|
|[[:human genes:h:hist2h3d|HIST2H3D]]|0.489|
|[[:human genes:c:c14orf93|C14orf93]]|0.489|
|[[:human genes:g:golga6l3|GOLGA6L3]]|0.488|
|[[:human genes:a:acsf2|ACSF2]]|0.488|
|[[:human genes:c:ccna2|CCNA2]]|0.486|
|[[:human genes:i:igfn1|IGFN1]]|0.486|
|[[:human genes:m:mt1e|MT1E]]|0.484|
|[[:human genes:n:nup54|NUP54]]|0.483|
|[[:human genes:m:madcam1|MADCAM1]]|0.482|
|[[:human genes:f:fcn2|FCN2]]|0.48|
|[[:human genes:e:exosc5|EXOSC5]]|0.478|
|[[:human genes:p:psmb2|PSMB2]]|0.477|
|[[:human genes:c:cdc6|CDC6]]|0.476|
|[[:human genes:g:golga6a|GOLGA6A]]|0.476|
|[[:human genes:s:slc4a1|SLC4A1]]|0.475|
|[[:human genes:e:exosc9|EXOSC9]]|0.475|
|[[:human genes:p:psmd11|PSMD11]]|0.474|
|[[:human genes:n:nol10|NOL10]]|0.474|
|[[:human genes:l:lrr1|LRR1]]|0.474|
|[[:human genes:p:pole|POLE]]|0.473|
|[[:human genes:r:rfxank|RFXANK]]|0.472|
|[[:human genes:t:terf1|TERF1]]|0.472|
|[[:human genes:s:s1pr4|S1PR4]]|0.471|
|[[:human genes:w:wdr87|WDR87]]|0.47|
|[[:human genes:n:narfl|NARFL]]|0.47|
|[[:human genes:p:polr2l|POLR2L]]|0.47|
|[[:human genes:i:ik|IK]]|0.469|
|[[:human genes:h:hivep3|HIVEP3]]|0.469|
|[[:human genes:e:ebna1bp2|EBNA1BP2]]|0.467|
|[[:human genes:c:cdc73|CDC73]]|0.467|
|[[:human genes:c:cdc45|CDC45]]|0.467|
|[[:human genes:s:sh3bp1|SH3BP1]]|0.467|
|[[:human genes:s:sf3a3|SF3A3]]|0.466|
|[[:human genes:m:myb|MYB]]|0.465|
|[[:human genes:c:ccdc64b|CCDC64B]]|0.465|
|[[:human genes:s:stil|STIL]]|0.464|
|[[:human genes:h:hist2h3c|HIST2H3C]]|0.463|
|[[:human genes:t:tspy8|TSPY8]]|0.463|
|[[:human genes:h:hist2h3a|HIST2H3A]]|0.463|
|[[:human genes:p:pde4dip|PDE4DIP]]|0.462|
|[[:human genes:n:nop16|NOP16]]|0.462|
|[[:human genes:x:xylt2|XYLT2]]|0.46|
|[[:human genes:n:npipb5|NPIPB5]]|0.46|
|[[:human genes:u:ubap1|UBAP1]]|0.459|
|[[:human genes:r:rpl35|RPL35]]|0.459|
|[[:human genes:n:nfatc4|NFATC4]]|0.459|
|[[:human genes:m:mylk3|MYLK3]]|0.459|
|[[:human genes:g:golga6l6|GOLGA6L6]]|0.459|
|[[:human genes:u:utp3|UTP3]]|0.459|
|[[:human genes:c:chaf1a|CHAF1A]]|0.459|
|[[:human genes:a:atxn1|ATXN1]]|0.457|
|[[:human genes:g:gprin2|GPRIN2]]|0.455|
|[[:human genes:r:rpl7l1|RPL7L1]]|0.455|
|[[:human genes:m:mbd3l2|MBD3L2]]|0.455|
|[[:human genes:n:nup133|NUP133]]|0.455|
|[[:human genes:g:gar1|GAR1]]|0.454|
|[[:human genes:m:msh5|MSH5]]|0.454|
|[[:human genes:p:psmc6|PSMC6]]|0.454|
|[[:human genes:d:dnm2|DNM2]]|0.453|
|[[:human genes:l:lad1|LAD1]]|0.452|
|[[:human genes:p:polr2j3|POLR2J3]]|0.452|
|[[:human genes:p:polr1a|POLR1A]]|0.452|
|[[:human genes:a:angptl4|ANGPTL4]]|0.451|
|[[:human genes:s:sec13|SEC13]]|0.451|
|[[:human genes:p:pola2|POLA2]]|0.45|
|[[:human genes:u:ube2q2l|UBE2Q2L]]|0.45|
|[[:human genes:r:rad21|RAD21]]|0.45|
|[[:human genes:p:pola1|POLA1]]|0.449|
|[[:human genes:r:riok2|RIOK2]]|0.448|
|[[:human genes:h:hist1h2be|HIST1H2BE]]|0.448|
|[[:human genes:r:rps28|RPS28]]|0.448|
|[[:human genes:r:rps7|RPS7]]|0.448|
|[[:human genes:p:polr2d|POLR2D]]|0.448|
|[[:human genes:b:brix1|BRIX1]]|0.447|
|[[:human genes:r:rpsa|RPSA]]|0.447|
|[[:human genes:m:myt1l|MYT1L]]|0.447|
|[[:human genes:d:disp2|DISP2]]|0.446|
|[[:human genes:r:rnpc3|RNPC3]]|0.446|
|[[:human genes:u:usp35|USP35]]|0.446|
|[[:human genes:h:hnrnpc|HNRNPC]]|0.446|
|[[:human genes:p:pan2|PAN2]]|0.446|
|[[:human genes:r:rrp7a|RRP7A]]|0.446|
|[[:human genes:t:traip|TRAIP]]|0.446|
|[[:human genes:a:ankle1|ANKLE1]]|0.446|
|[[:human genes:m:myh7b|MYH7B]]|0.445|
|[[:human genes:t:timeless|TIMELESS]]|0.444|
|[[:human genes:a:aamp|AAMP]]|0.443|
|[[:human genes:p:pcf11|PCF11]]|0.443|
|[[:human genes:u:usp36|USP36]]|0.442|
|[[:human genes:m:med17|MED17]]|0.442|
|[[:human genes:r:rbm39|RBM39]]|0.441|
|[[:human genes:m:myo1h|MYO1H]]|0.441|
|[[:human genes:d:dock6|DOCK6]]|0.441|
|[[:human genes:n:nbpf10|NBPF10]]|0.44|
|[[:human genes:c:cope|COPE]]|0.44|
|[[:human genes:t:top1mt|TOP1MT]]|0.439|
|[[:human genes:p:psmd2|PSMD2]]|0.439|
|[[:human genes:g:golga6l4|GOLGA6L4]]|0.438|
|[[:human genes:d:ddx51|DDX51]]|0.438|
|[[:human genes:r:rpl6|RPL6]]|0.438|
|[[:human genes:s:slc6a17|SLC6A17]]|0.437|
|[[:human genes:d:dhx38|DHX38]]|0.437|
|[[:human genes:k:kif3c|KIF3C]]|0.437|
|[[:human genes:n:nufip2|NUFIP2]]|0.437|
|[[:human genes:b:bage3|BAGE3]]|0.436|
|[[:human genes:b:bage2|BAGE2]]|0.436|
|[[:human genes:o:ogfr|OGFR]]|0.436|
|[[:human genes:z:znf830|ZNF830]]|0.436|
|[[:human genes:k:kpnb1|KPNB1]]|0.436|
|[[:human genes:g:golga8o|GOLGA8O]]|0.436|
|[[:human genes:p:psmd7|PSMD7]]|0.436|
|[[:human genes:b:bage|BAGE]]|0.436|
|[[:human genes:m:med14|MED14]]|0.435|
|[[:human genes:c:cgb2|CGB2]]|0.435|
|[[:human genes:c:cox7a2l|COX7A2L]]|0.435|
|[[:human genes:r:rrn3|RRN3]]|0.435|
|[[:human genes:r:rps3a|RPS3A]]|0.435|
|[[:human genes:a:aprt|APRT]]|0.435|
|[[:human genes:b:bage4|BAGE4]]|0.435|
|[[:human genes:b:bage5|BAGE5]]|0.435|
|[[:human genes:c:col2a1|COL2A1]]|0.434|
|[[:human genes:v:vps54|VPS54]]|0.433|
|[[:human genes:a:ahctf1|AHCTF1]]|0.433|
|[[:human genes:b:brd2|BRD2]]|0.433|
|[[:human genes:c:cdca3|CDCA3]]|0.432|
|[[:human genes:p:psmd14|PSMD14]]|0.432|
|[[:human genes:r:rps19|RPS19]]|0.432|
|[[:human genes:r:rfc1|RFC1]]|0.431|
|[[:human genes:d:ddt|DDT]]|0.431|
|[[:human genes:p:psmc2|PSMC2]]|0.429|
|[[:human genes:u:upf1|UPF1]]|0.429|
|[[:human genes:z:zfand5|ZFAND5]]|0.429|
|[[:human genes:d:ddx56|DDX56]]|0.428|
|[[:human genes:n:npipb4|NPIPB4]]|0.428|
|[[:human genes:c:chmp4b|CHMP4B]]|0.428|
|[[:human genes:r:rpl34|RPL34]]|0.428|
|[[:human genes:s:smg7|SMG7]]|0.427|
|[[:human genes:p:psmc1|PSMC1]]|0.427|
|[[:human genes:e:exd1|EXD1]]|0.426|
|[[:human genes:r:rps11|RPS11]]|0.426|
|[[:human genes:n:napa|NAPA]]|0.425|
|[[:human genes:c:cmya5|CMYA5]]|0.425|
|[[:human genes:f:fam160a1|FAM160A1]]|0.425|
|[[:human genes:r:ranbp2|RANBP2]]|0.425|
|[[:human genes:i:iscu|ISCU]]|0.424|
|[[:human genes:e:exosc3|EXOSC3]]|0.424|
|[[:human genes:e:elmod3|ELMOD3]]|0.424|
|[[:human genes:r:rnf113a|RNF113A]]|0.423|
|[[:human genes:m:myo18a|MYO18A]]|0.423|
|[[:human genes:p:polr2f|POLR2F]]|0.423|
|[[:human genes:p:psmd3|PSMD3]]|0.422|
|[[:human genes:n:nup43|NUP43]]|0.421|
|[[:human genes:t:tp53tg3d|TP53TG3D]]|0.421|
|[[:human genes:s:supt6h|SUPT6H]]|0.421|
|[[:human genes:z:znf541|ZNF541]]|0.421|
|[[:human genes:c:copa|COPA]]|0.421|
|[[:human genes:n:naaladl1|NAALADL1]]|0.42|
|[[:human genes:c:chmp2a|CHMP2A]]|0.42|
|[[:human genes:n:nol7|NOL7]]|0.419|
|[[:human genes:p:pwp2|PWP2]]|0.418|
|[[:human genes:a:apc2|APC2]]|0.418|
|[[:human genes:m:mfsd12|MFSD12]]|0.417|
|[[:human genes:p:plk4|PLK4]]|0.417|
|[[:human genes:p:plxnb3|PLXNB3]]|0.416|
|[[:human genes:n:npipb8|NPIPB8]]|0.414|
|[[:human genes:r:rpl9|RPL9]]|0.414|
|[[:human genes:u:uqcrh|UQCRH]]|0.414|
|[[:human genes:s:slc23a3|SLC23A3]]|0.414|
|[[:human genes:s:snrnp70|SNRNP70]]|0.414|
|[[:human genes:s:sf3a1|SF3A1]]|0.414|
|[[:human genes:n:nup160|NUP160]]|0.413|
|[[:human genes:o:or10g3|OR10G3]]|0.412|
|[[:human genes:n:nsf|NSF]]|0.412|
|[[:human genes:s:smg1|SMG1]]|0.412|
|[[:human genes:c:c2orf27b|C2orf27B]]|0.411|
|[[:human genes:f:fam25b|FAM25B]]|0.41|
|[[:human genes:r:rffl|RFFL]]|0.41|
|[[:human genes:d:ddx47|DDX47]]|0.41|
|[[:human genes:r:rpl14|RPL14]]|0.409|
|[[:human genes:s:slc22a6|SLC22A6]]|0.409|
|[[:human genes:r:rad51|RAD51]]|0.409|
|[[:human genes:s:snrpa1|SNRPA1]]|0.409|
|[[:human genes:z:znf655|ZNF655]]|0.409|
|[[:human genes:k:kiaa0947|KIAA0947]]|0.409|
|[[:human genes:s:supt5h|SUPT5H]]|0.409|
|[[:human genes:c:ckap5|CKAP5]]|0.409|
|[[:human genes:w:wdr75|WDR75]]|0.409|
|[[:human genes:m:mdm2|MDM2]]|0.408|
|[[:human genes:a:atp6v0b|ATP6V0B]]|0.408|
|[[:human genes:d:diexf|DIEXF]]|0.408|
|[[:human genes:r:rps9|RPS9]]|0.408|
|[[:human genes:g:gid4|GID4]]|0.407|
|[[:human genes:m:mki67ip|MKI67IP]]|0.407|
|[[:human genes:e:exosc6|EXOSC6]]|0.406|
|[[:human genes:s:smtn|SMTN]]|0.406|
|[[:human genes:r:rps3|RPS3]]|0.406|
|[[:human genes:a:arcn1|ARCN1]]|0.406|
|[[:human genes:c:cnpy3|CNPY3]]|0.405|
|[[:human genes:c:crnkl1|CRNKL1]]|0.404|
|[[:human genes:l:loc643669|LOC643669]]|0.403|
|[[:human genes:h:htatsf1|HTATSF1]]|0.403|
|[[:human genes:c:ccdc116|CCDC116]]|0.403|
|[[:human genes:h:hist1h4b|HIST1H4B]]|0.402|
|[[:human genes:s:scaf1|SCAF1]]|0.402|
|[[:human genes:r:rilpl2|RILPL2]]|0.402|
|[[:human genes:p:pop1|POP1]]|0.402|
|[[:human genes:a:akap1|AKAP1]]|0.402|
|[[:human genes:p:ppfia4|PPFIA4]]|0.402|
|[[:human genes:t:tyms|TYMS]]|0.401|
|[[:human genes:a:atp6ap1|ATP6AP1]]|0.401|
|[[:human genes:p:pold2|POLD2]]|0.401|
|[[:human genes:p:pes1|PES1]]|0.4|
|[[:human genes:o:osbp|OSBP]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2038
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.99 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KCTD17 Expression in NALM6 Cells: 5.99'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>