======= KEAP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KEAP1
  * **<color #00a2e8>Official Name</color>**: kelch like ECH associated protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9817|9817]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q14145|Q14145]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KEAP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KEAP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606016|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome. {ECO:0000269|PubMed:14585973, ECO:0000269|PubMed:15379550, ECO:0000269|PubMed:15572695, ECO:0000269|PubMed:15983046, ECO:0000269|PubMed:17046835}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Kelch 2|
|Kelch 1|
|BTB|
|BACK|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cytoplasmic sequestering of transcription factor|
|cytoplasmic sequestering of protein|
|proteasomal ubiquitin-independent protein catabolic process|
|cellular response to interleukin-4|
|response to interleukin-4|
|disordered domain specific binding|
|Cul3-RING ubiquitin ligase complex|
|regulation of epidermal cell differentiation|
|actin filament|
|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|
|regulation of epidermis development|
|positive regulation of ubiquitin-dependent protein catabolic process|
|positive regulation of proteasomal protein catabolic process|
|maintenance of protein location|
|positive regulation of proteolysis involved in cellular protein catabolic process|
|regulation of proteasomal ubiquitin-dependent protein catabolic process|
|positive regulation of cellular protein catabolic process|
|regulation of epithelial cell differentiation|
|regulation of ubiquitin-dependent protein catabolic process|
|microtubule organizing center|
|midbody|
|negative regulation of DNA-binding transcription factor activity|
|maintenance of location|
|regulation of proteasomal protein catabolic process|
|regulation of proteolysis involved in cellular protein catabolic process|
|positive regulation of protein catabolic process|
|regulation of cellular protein catabolic process|
|protein deubiquitination|
|protein modification by small protein removal|
|transcription factor binding|
|proteasomal protein catabolic process|
|positive regulation of proteolysis|
|post-translational protein modification|
|positive regulation of cellular catabolic process|
|in utero embryonic development|
|regulation of protein catabolic process|
|regulation of DNA-binding transcription factor activity|
|positive regulation of catabolic process|
|proteolysis involved in cellular protein catabolic process|
|cellular protein catabolic process|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|protein catabolic process|
|protein ubiquitination|
|viral process|
|regulation of proteolysis|
|protein modification by small protein conjugation|
|symbiotic process|
|interspecies interaction between organisms|
|regulation of cellular catabolic process|
|protein homodimerization activity|
|cellular macromolecule catabolic process|
|embryo development|
|protein modification by small protein conjugation or removal|
|regulation of catabolic process|
|cellular response to cytokine stimulus|
|endoplasmic reticulum|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|response to cytokine|
|negative regulation of molecular function|
|proteolysis|
|positive regulation of cellular protein metabolic process|
|positive regulation of protein metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
|regulation of cell differentiation|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|-2.75|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|-2.72|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|-2.6|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|-2.55|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|-2.4|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|-2.32|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|-2.28|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|-2.26|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|-2.25|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|-2.2|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|-2.12|
|[[:results:exp116|AICAR 240μM R03 exp116]]|-2.09|
|[[:results:exp359|FK-506 30μM R07 exp359]]|-2.06|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|-1.98|
|[[:results:exp438|NN-Diethyl-meta-toluamide 500μM R08 exp438]]|-1.93|
|[[:results:exp73|LJH685 5μM R02 exp73]]|-1.93|
|[[:results:exp72|LB-100 4.1μM R02 exp72]]|-1.92|
|[[:results:exp223|Cabazitaxel 0.001μM R05 exp223]]|-1.84|
|[[:results:exp405|Tenofovir 10μM R07 exp405]]|-1.83|
|[[:results:exp351|Dexamethasone 0.006μM R07 exp351]]|-1.8|
|[[:results:exp238|Parthenolide 2.5μM R05 exp238]]|-1.79|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|-1.79|
|[[:results:exp176|Apcin 50 to 100μM on day4 R04 exp176]]|-1.77|
|[[:results:exp210|LB-100 2μM R05 exp210]]|-1.77|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|-1.76|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|-1.75|
|[[:results:exp179|Combretastatin A4 0.002 to 0.003μM day4 R04 exp179]]|-1.74|
|[[:results:exp330|5-Azacytidine 2μM R07 exp330]]|-1.71|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|-1.7|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|1.78|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|1.78|
|[[:results:exp230|Epigallocatechin gallate 20μM R05 exp230]]|1.87|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|2.43|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|2.46|
|[[:results:exp449|Arsenic trioxide 60μM R08 exp449]]|4.24|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:b:bach2|BACH2]]|0.421|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 26/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|0/28|
|bone|0/26|
|breast|6/33|
|central nervous system|1/56|
|cervix|2/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|1/21|
|liver|1/20|
|lung|2/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|3/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16203
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.18 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KEAP1 Expression in NALM6 Cells: 6.18'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>