======= KIAA0753 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KIAA0753
  * **<color #00a2e8>Official Name</color>**: KIAA0753
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9851|9851]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q2KHM9|Q2KHM9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KIAA0753&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KIAA0753|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617112|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a subunit of a protein complex that regulates ciliogenesis and cilia maintenance. The encoded protein has also been shown to regulate centriolar duplication. Mutations in this gene cause an orofaciodigital syndrome and a form of Joubert syndrome in human patients. [provided by RefSeq, May 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in centriole duplication. Positively regulates CEP63 centrosomal localization. Required for WDR62 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:24613305, PubMed:26297806). {ECO:0000269|PubMed:26297806}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|centriole replication|
|protein localization to centrosome|
|protein localization to microtubule organizing center|
|centriole assembly|
|centrosome duplication|
|centriolar satellite|
|protein localization to microtubule cytoskeleton|
|protein localization to cytoskeleton|
|centrosome cycle|
|microtubule organizing center organization|
|centriole|
|microtubule cytoskeleton organization|
|centrosome|
|microtubule-based process|
|protein localization to organelle|
|organelle assembly|
|cell cycle process|
|cytoskeleton organization|
|cell cycle|
|cellular protein localization|
|cellular macromolecule localization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|-1.98|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|-1.85|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|-1.78|
|[[:results:exp155|UNC1999 2μM R03 exp155]]|1.71|
|[[:results:exp330|5-Azacytidine 2μM R07 exp330]]|1.72|
|[[:results:exp341|BRD2 inhibitor II 20μM R07 exp341]]|1.75|
|[[:results:exp134|MS023 2μM R03 exp134]]|1.75|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|1.86|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|3.92|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|5.68|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|6.75|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|7.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:cradd|CRADD]]|0.732|
|[[:human genes:c:c2cd3|C2CD3]]|0.714|
|[[:human genes:p:pidd|PIDD]]|0.707|
|[[:human genes:c:casp2|CASP2]]|0.695|
|[[:human genes:o:ofd1|OFD1]]|0.656|
|[[:human genes:p:pibf1|PIBF1]]|0.646|
|[[:human genes:o:odf2|ODF2]]|0.618|
|[[:human genes:n:nin|NIN]]|0.602|
|[[:human genes:c:cep128|CEP128]]|0.6|
|[[:human genes:a:ankrd26|ANKRD26]]|0.598|
|[[:human genes:c:cep120|CEP120]]|0.591|
|[[:human genes:c:c16orf59|C16orf59]]|0.589|
|[[:human genes:c:cep76|CEP76]]|0.586|
|[[:human genes:c:ccdc41|CCDC41]]|0.582|
|[[:human genes:f:fopnl|FOPNL]]|0.568|
|[[:human genes:s:sclt1|SCLT1]]|0.566|
|[[:human genes:c:c14orf80|C14orf80]]|0.55|
|[[:human genes:c:cep78|CEP78]]|0.528|
|[[:human genes:t:tubd1|TUBD1]]|0.489|
|[[:human genes:c:cep44|CEP44]]|0.469|
|[[:human genes:r:rttn|RTTN]]|0.464|
|[[:human genes:c:cep152|CEP152]]|0.439|
|[[:human genes:h:hyls1|HYLS1]]|0.426|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15964
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.59 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KIAA0753 Expression in NALM6 Cells: 4.59'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>