======= KIAA1199 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CEMIP
  * **<color #00a2e8>Official Name</color>**: cell migration inducing hyaluronidase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=57214|57214]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8WUJ3|Q8WUJ3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KIAA1199&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KIAA1199|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608366|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Mediates depolymerization of hyaluronic acid (HA) via the cell membrane-associated clathrin-coated pit endocytic pathway. Binds to hyaluronic acid. Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product, a process that may occur through rapid vesicle endocytosis and recycling without intracytoplasmic accumulation or digestion in lysosomes. Involved in hyaluronan catabolism in the dermis of the skin and arthritic synovium. Positively regulates epithelial- mesenchymal transition (EMT), and hence tumor cell growth, invasion and cancer dissemination. In collaboration with HSPA5/BIP, promotes cancer cell migration in a calcium and PKC- dependent manner. May be involved in hearing. {ECO:0000269|PubMed:23509262, ECO:0000269|PubMed:23990668, ECO:0000269|PubMed:24269685}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|G8|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ER retention sequence binding|
|positive regulation of protein kinase C activity|
|regulation of protein kinase C activity|
|hyaluronan biosynthetic process|
|clathrin heavy chain binding|
|hyalurononglucosaminidase activity|
|hyaluronan catabolic process|
|hyaluronic acid binding|
|clathrin-coated endocytic vesicle|
|positive regulation of peptidyl-threonine phosphorylation|
|hyaluronan metabolic process|
|positive regulation of protein targeting to membrane|
|regulation of protein targeting to membrane|
|positive regulation of release of sequestered calcium ion into cytosol|
|regulation of peptidyl-threonine phosphorylation|
|clathrin-coated vesicle membrane|
|positive regulation of calcium ion transport into cytosol|
|clathrin-coated pit|
|glycosaminoglycan catabolic process|
|aminoglycan catabolic process|
|positive regulation of calcium ion transmembrane transport|
|regulation of release of sequestered calcium ion into cytosol|
|regulation of protein targeting|
|regulation of calcium ion transport into cytosol|
|glycosaminoglycan biosynthetic process|
|mucopolysaccharide metabolic process|
|aminoglycan biosynthetic process|
|positive regulation of calcium ion transport|
|positive regulation of protein localization to membrane|
|regulation of sequestering of calcium ion|
|positive regulation of cation transmembrane transport|
|sensory perception of sound|
|regulation of calcium ion transmembrane transport|
|positive regulation of intracellular protein transport|
|positive regulation of ion transmembrane transport|
|glycosaminoglycan metabolic process|
|aminoglycan metabolic process|
|sensory perception of mechanical stimulus|
|regulation of protein localization to membrane|
|carbohydrate derivative catabolic process|
|positive regulation of transmembrane transport|
|positive regulation of intracellular transport|
|regulation of intracellular protein transport|
|regulation of calcium ion transport|
|organic acid catabolic process|
|carboxylic acid catabolic process|
|positive regulation of ion transport|
|positive regulation of cytosolic calcium ion concentration|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|positive regulation of cellular protein localization|
|regulation of cytosolic calcium ion concentration|
|regulation of cation transmembrane transport|
|positive regulation of protein serine/threonine kinase activity|
|regulation of intracellular transport|
|regulation of metal ion transport|
|positive regulation of protein transport|
|cellular calcium ion homeostasis|
|small molecule catabolic process|
|calcium ion homeostasis|
|positive regulation of establishment of protein localization|
|cellular divalent inorganic cation homeostasis|
|regulation of ion transmembrane transport|
|divalent inorganic cation homeostasis|
|positive regulation of cell migration|
|regulation of protein serine/threonine kinase activity|
|positive regulation of cell motility|
|positive regulation of protein kinase activity|
|positive regulation of cellular component movement|
|regulation of cellular protein localization|
|positive regulation of locomotion|
|cellular metal ion homeostasis|
|regulation of transmembrane transport|
|positive regulation of kinase activity|
|small molecule biosynthetic process|
|carbohydrate derivative biosynthetic process|
|metal ion homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|positive regulation of transferase activity|
|regulation of ion transport|
|cation homeostasis|
|regulation of protein transport|
|inorganic ion homeostasis|
|regulation of peptide transport|
|cellular chemical homeostasis|
|regulation of establishment of protein localization|
|ion homeostasis|
|regulation of protein kinase activity|
|regulation of cell migration|
|regulation of kinase activity|
|cellular homeostasis|
|carboxylic acid metabolic process|
|regulation of cell motility|
|regulation of cellular localization|
|sensory perception|
|regulation of transferase activity|
|regulation of locomotion|
|positive regulation of transport|
|regulation of cellular component movement|
|oxoacid metabolic process|
|endoplasmic reticulum|
|positive regulation of protein phosphorylation|
|organic acid metabolic process|
|carbohydrate derivative metabolic process|
|regulation of protein localization|
|macromolecule catabolic process|
|positive regulation of phosphorylation|
|organonitrogen compound catabolic process|
|chemical homeostasis|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of protein modification process|
|nervous system process|
|organonitrogen compound biosynthetic process|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|homeostatic process|
|positive regulation of protein metabolic process|
|small molecule metabolic process|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|cellular catabolic process|
|regulation of protein modification process|
|regulation of transport|
|extracellular region|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp423|Zebularine 20μM R07 exp423]]|-1.82|
|[[:results:exp81|Selumetinib 20μM R02 exp81]]|1.94|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.606|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4270
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.14 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KIAA1199 Expression in NALM6 Cells: 1.14'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>