======= KIAA1551 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RESF1
  * **<color #00a2e8>Official Name</color>**: retroelement silencing factor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55196|55196]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9HCM1|Q9HCM1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KIAA1551&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KIAA1551|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615621|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of methylation-dependent chromatin silencing|
|regulation of methylation-dependent chromatin silencing|
|positive regulation of chromatin silencing|
|negative regulation of single stranded viral RNA replication via double stranded DNA intermediate|
|gamma-tubulin complex|
|regulation of single stranded viral RNA replication via double stranded DNA intermediate|
|regulation of chromatin silencing|
|negative regulation of viral genome replication|
|negative regulation of viral life cycle|
|regulation of viral genome replication|
|negative regulation of viral process|
|positive regulation of chromatin organization|
|regulation of gene silencing|
|histone binding|
|regulation of viral life cycle|
|positive regulation of chromosome organization|
|regulation of chromatin organization|
|regulation of viral process|
|negative regulation of multi-organism process|
|regulation of symbiosis, encompassing mutualism through parasitism|
|regulation of chromosome organization|
|positive regulation of organelle organization|
|regulation of multi-organism process|
|positive regulation of cellular component organization|
|regulation of organelle organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp81|Selumetinib 20μM R02 exp81]]|-2.02|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|-1.87|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|-1.7|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|1.7|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|1.85|
|[[:results:exp534|Trientine 500μM R08 exp534]]|1.97|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|2.13|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|2.3|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|2.38|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14125
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.59 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KIAA1551 Expression in NALM6 Cells: 6.59'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>