======= KIF11 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KIF11
  * **<color #00a2e8>Official Name</color>**: kinesin family member 11
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3832|3832]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P52732|P52732]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KIF11&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KIF11|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/148760|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a motor protein that belongs to the kinesin-like protein family. Members of this protein family are known to be involved in various kinds of spindle dynamics. The function of this gene product includes chromosome positioning, centrosome separation and establishing a bipolar spindle during cell mitosis. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Motor protein required for establishing a bipolar spindle during mitosis (PubMed:19001501). Required in non-mitotic cells for transport of secretory proteins from the Golgi complex to the cell surface (PubMed:23857769). {ECO:0000269|PubMed:19001501, ECO:0000269|PubMed:23857769}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Kinesin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitotic centrosome separation|
|centrosome separation|
|regulation of mitotic centrosome separation|
|ATP-dependent microtubule motor activity, plus-end-directed|
|spindle microtubule|
|mitotic spindle assembly|
|kinesin complex|
|regulation of centrosome cycle|
|microtubule motor activity|
|mitotic spindle organization|
|mitotic spindle|
|centrosome cycle|
|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|
|microtubule organizing center organization|
|antigen processing and presentation of exogenous peptide antigen via MHC class II|
|antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|
|antigen processing and presentation of peptide antigen via MHC class II|
|spindle assembly|
|microtubule cytoskeleton organization involved in mitosis|
|spindle|
|spindle pole|
|mitotic nuclear division|
|spindle organization|
|regulation of mitotic nuclear division|
|antigen processing and presentation of exogenous peptide antigen|
|antigen processing and presentation of exogenous antigen|
|regulation of microtubule cytoskeleton organization|
|antigen processing and presentation of peptide antigen|
|regulation of nuclear division|
|antigen processing and presentation|
|regulation of microtubule-based process|
|ATPase activity|
|microtubule binding|
|microtubule-based movement|
|nuclear division|
|organelle fission|
|microtubule|
|Golgi vesicle transport|
|protein kinase binding|
|microtubule cytoskeleton organization|
|cell division|
|regulation of cytoskeleton organization|
|protein-containing complex|
|mitotic cell cycle process|
|regulation of mitotic cell cycle|
|microtubule-based process|
|mitotic cell cycle|
|regulation of cell cycle process|
|organelle assembly|
|cell cycle process|
|cytoskeleton organization|
|regulation of cell cycle|
|regulation of organelle organization|
|cell cycle|
|ATP binding|
|movement of cell or subcellular component|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp312|2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312]]|-2.39|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|-2.34|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|-2.25|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|-2.06|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|-2.02|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|-2.02|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|-2.01|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|-2|
|[[:results:exp310|2-Methoxyestradiol 0.55μM R07 exp310]]|-1.98|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|-1.86|
|[[:results:exp82|Torin1 0.08μM R02 exp82]]|-1.84|
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|-1.83|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|-1.81|
|[[:results:exp300|VE-822 0.04μM R06 exp300]]|-1.78|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|-1.74|
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|-1.74|
|[[:results:exp10|CCCP 0.1μM R00 exp10]]|1.7|
|[[:results:exp132|Metformin 40μM R03 exp132]]|1.72|
|[[:results:exp11|CCCP 1μM R00 exp11]]|1.75|
|[[:results:exp326|CCT251545 20μM R07 exp326]]|1.77|
|[[:results:exp246|UM0011500 10μM R05 exp246]]|1.77|
|[[:results:exp153|SGC2096 2.6μM R03 exp153]]|1.78|
|[[:results:exp114|A-196 10μM R03 exp114]]|1.85|
|[[:results:exp236|GSK2606414 1μM R05 exp236]]|1.89|
|[[:results:exp165|RO-3306 3 to 4μM on day4 R04 exp165]]|1.9|
|[[:results:exp107|UMK57 0.6μM R03 exp107]]|1.94|
|[[:results:exp115|A-366 10μM R03 exp115]]|1.96|
|[[:results:exp123|GSK-LSD1 10μM R03 exp123]]|1.98|
|[[:results:exp279|D-Fructose 10000μM R06 exp279]]|2.01|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|2.09|
|[[:results:exp73|LJH685 5μM R02 exp73]]|2.19|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|2.26|
|[[:results:exp23|Nocodazole 0.02μM R00 exp23]]|2.7|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|2.73|
|[[:results:exp14|Cycloheximide 0.02μM R00 exp14]]|2.76|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|2.85|
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|3|
|[[:results:exp15|Cycloheximide 0.2μM R00 exp15]]|3.05|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|3.11|
|[[:results:exp27|Pimelic-diphenylamide-106 0.5μM R00 exp27]]|3.3|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|3.45|
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|3.69|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:s:syt9|SYT9]]|0.407|
|[[:human genes:p:polr2j3|POLR2J3]]|0.403|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 737/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|27/28|
|bone|26/26|
|breast|33/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|20/20|
|lung|75/75|
|lymphocyte|16/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|28/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 25
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.85 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KIF11 Expression in NALM6 Cells: 7.85'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>