======= KIF18B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KIF18B
  * **<color #00a2e8>Official Name</color>**: kinesin family member 18B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=146909|146909]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q86Y91|Q86Y91]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KIF18B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KIF18B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/614570|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  In complex with KIF2C, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Its major role may be to transport KIF2C and/or MAPRE1 along microtubules. {ECO:0000269|PubMed:20600703, ECO:0000269|PubMed:21820309}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Kinesin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|microtubule end|
|astral microtubule|
|mitotic spindle astral microtubule|
|mitotic spindle midzone|
|microtubule depolymerization|
|microtubule plus-end|
|ATP-dependent microtubule motor activity, plus-end-directed|
|protein depolymerization|
|kinesin binding|
|motor activity|
|microtubule polymerization or depolymerization|
|kinesin complex|
|microtubule motor activity|
|mitotic sister chromatid segregation|
|cellular protein complex disassembly|
|sister chromatid segregation|
|mitotic nuclear division|
|regulation of cell division|
|nuclear chromosome segregation|
|ATPase activity|
|microtubule binding|
|protein-containing complex disassembly|
|microtubule-based movement|
|chromosome segregation|
|nuclear body|
|nuclear division|
|organelle fission|
|microtubule|
|cellular component disassembly|
|supramolecular fiber organization|
|microtubule cytoskeleton organization|
|cell division|
|mitotic cell cycle process|
|microtubule-based process|
|mitotic cell cycle|
|cell cycle process|
|chromosome organization|
|cytoskeleton organization|
|cell cycle|
|ATP binding|
|movement of cell or subcellular component|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|-5.38|
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|-5.37|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|-4.56|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|-4.26|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|-3.67|
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|-2.82|
|[[:results:exp223|Cabazitaxel 0.001μM R05 exp223]]|-2.78|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|-2.39|
|[[:results:exp344|Chlorpromazine 10μM R07 exp344]]|-2.36|
|[[:results:exp159|Docetaxel 0.001 to 0.002μM on day4 R04 exp159]]|-2.13|
|[[:results:exp310|2-Methoxyestradiol 0.55μM R07 exp310]]|2.48|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|2.8|
|[[:results:exp312|2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312]]|2.89|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|3.13|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|3.29|
|[[:results:exp311|2-Methoxyestradiol 0.55 to 0.75μM  on day4 R07 exp311]]|4.37|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|7.08|
|[[:results:exp59|UMK57 1μM R01 exp59]]|7.13|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|7.96|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:k:kif2c|KIF2C]]|0.762|
|[[:human genes:k:kif4a|KIF4A]]|0.494|
|[[:human genes:p:ppp2r5c|PPP2R5C]]|0.481|
|[[:human genes:p:ppp2r1a|PPP2R1A]]|0.439|
|[[:human genes:a:atat1|ATAT1]]|0.419|
|[[:human genes:t:ttl|TTL]]|0.415|
|[[:human genes:c:clasp2|CLASP2]]|0.414|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 84/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|3/28|
|blood|1/28|
|bone|4/26|
|breast|1/33|
|central nervous system|15/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|8/21|
|liver|2/20|
|lung|4/75|
|lymphocyte|1/16|
|ovary|3/26|
|pancreas|0/24|
|peripheral nervous system|2/16|
|plasma cell|2/15|
|prostate|0/1|
|skin|4/24|
|soft tissue|2/9|
|thyroid|1/2|
|upper aerodigestive|5/22|
|urinary tract|5/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4945
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.83 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KIF18B Expression in NALM6 Cells: 6.83'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>