======= KIF22 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KIF22
  * **<color #00a2e8>Official Name</color>**: kinesin family member 22
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3835|3835]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q14807|Q14807]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KIF22&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KIF22|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603213|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the kinesin-like protein family. The family members are microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. The C-terminal half of this protein has been shown to bind DNA. Studies with the Xenopus homolog suggests its essential role in metaphase chromosome alignment and maintenance. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Kinesin family member that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis. Binds to microtubules and to DNA (By similarity). Plays a role in congression of laterally attached chromosomes in NDC80- depleted cells (PubMed:25743205). {ECO:0000250|UniProtKB:Q9I869, ECO:0000269|PubMed:25743205}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|HHH 3|
|Kinesin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitotic metaphase plate congression|
|sister chromatid cohesion|
|kinesin complex|
|metaphase plate congression|
|microtubule motor activity|
|establishment of chromosome localization|
|chromosome localization|
|mitotic spindle|
|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|
|kinetochore|
|antigen processing and presentation of exogenous peptide antigen via MHC class II|
|antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|
|antigen processing and presentation of peptide antigen via MHC class II|
|mitotic sister chromatid segregation|
|chromatin|
|sister chromatid segregation|
|mitotic nuclear division|
|antigen processing and presentation of exogenous peptide antigen|
|antigen processing and presentation of exogenous antigen|
|antigen processing and presentation of peptide antigen|
|antigen processing and presentation|
|nuclear chromosome segregation|
|ATPase activity|
|microtubule binding|
|microtubule-based movement|
|chromosome segregation|
|nuclear division|
|organelle fission|
|microtubule|
|establishment of organelle localization|
|Golgi vesicle transport|
|nuclear speck|
|DNA repair|
|organelle localization|
|mitotic cell cycle process|
|microtubule-based process|
|mitotic cell cycle|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|cell cycle process|
|chromosome organization|
|cell cycle|
|DNA binding|
|ATP binding|
|movement of cell or subcellular component|
|cellular response to stress|
|establishment of localization in cell|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|-2.64|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|-2.15|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|-2|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|-1.78|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 4/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5856
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.65 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KIF22 Expression in NALM6 Cells: 7.65'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>