======= KLF16 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KLF16
  * **<color #00a2e8>Official Name</color>**: Kruppel like factor 16
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=83855|83855]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BXK1|Q9BXK1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KLF16&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KLF16|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606139|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Transcription factor that binds GC and GT boxes and displaces Sp1 and Sp3 from these sequences. Modulates dopaminergic transmission in the brain (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-C2H2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|dopamine receptor signaling pathway|
|cellular response to dopamine|
|response to dopamine|
|signal transduction involved in cellular response to ammonium ion|
|cellular response to catecholamine stimulus|
|cellular response to monoamine stimulus|
|response to monoamine|
|response to catecholamine|
|cellular response to ammonium ion|
|response to ammonium ion|
|DNA-binding transcription repressor activity, RNA polymerase II-specific|
|cellular response to drug|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|cellular response to organic cyclic compound|
|cellular response to organonitrogen compound|
|cellular response to nitrogen compound|
|negative regulation of transcription by RNA polymerase II|
|response to organic cyclic compound|
|response to organonitrogen compound|
|response to drug|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|negative regulation of transcription, DNA-templated|
|cellular response to endogenous stimulus|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|negative regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|-3.62|
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|-3.53|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|-2.78|
|[[:results:exp125|GSK461364A 0.005μM R03 exp125]]|-2.54|
|[[:results:exp179|Combretastatin A4 0.002 to 0.003μM day4 R04 exp179]]|-2.49|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|-2.49|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|-2.2|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|-2.15|
|[[:results:exp59|UMK57 1μM R01 exp59]]|-2.02|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|-2|
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|-1.96|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|-1.95|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|-1.93|
|[[:results:exp159|Docetaxel 0.001 to 0.002μM on day4 R04 exp159]]|-1.9|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|-1.78|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|-1.77|
|[[:results:exp506|Momordin-Ic 10μM R08 exp506]]|1.7|
|[[:results:exp271|CCT251545 0.2μM R06 exp271]]|1.72|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|1.73|
|[[:results:exp461|BS-181 20μM R08 exp461]]|1.75|
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|1.77|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|1.8|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|1.83|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|1.87|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|1.9|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|1.9|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|1.91|
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|2|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|2.02|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|2.04|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|2.05|
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|2.05|
|[[:results:exp528|TGF-beta1 44ng/ml R08 exp528]]|2.05|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|2.08|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|2.1|
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|2.12|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|2.2|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|2.23|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|2.3|
|[[:results:exp120|Dimethyl-Sulfoxide 1pc R03 exp120]]|2.43|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|2.44|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|2.46|
|[[:results:exp360|Genistein 15μM R07 exp360]]|2.58|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|2.64|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|2.68|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|2.72|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|2.72|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|2.72|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|2.76|
|[[:results:exp433|LJH685 50μM R08 exp433]]|2.79|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|2.81|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|2.83|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|2.92|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|2.97|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|3.21|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|3.49|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|3.51|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|3.72|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|4.53|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|4.64|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|4.99|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:d:dlgap5|DLGAP5]]|0.5|
|[[:human genes:t:tacc3|TACC3]]|0.448|
|[[:human genes:d:dazap1|DAZAP1]]|0.418|
|[[:human genes:l:lrrc8a|LRRC8A]]|0.417|
|[[:human genes:k:kif15|KIF15]]|0.412|
|[[:human genes:p:pmvk|PMVK]]|0.407|
|[[:human genes:k:klf13|KLF13]]|0.405|
|[[:human genes:a:aspm|ASPM]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5649
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.86 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KLF16 Expression in NALM6 Cells: 5.86'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>