======= KLHL22 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KLHL22
  * **<color #00a2e8>Official Name</color>**: kelch like family member 22
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=84861|84861]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q53GT1|Q53GT1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KLHL22&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KLHL22|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/618020|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of PLK1 at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. Monoubiquitination of PLK1 does not lead to PLK1 degradation. {ECO:0000269|PubMed:19995937, ECO:0000269|PubMed:23455478}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|BACK|
|BTB|
|Kelch 1|
|Kelch 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|polar microtubule|
|cellular response to leucine|
|response to leucine|
|positive regulation of TORC1 signaling|
|spindle checkpoint|
|mitotic spindle assembly checkpoint|
|spindle assembly checkpoint|
|mitotic spindle checkpoint|
|negative regulation of mitotic metaphase/anaphase transition|
|negative regulation of metaphase/anaphase transition of cell cycle|
|negative regulation of mitotic sister chromatid separation|
|negative regulation of chromosome separation|
|14-3-3 protein binding|
|negative regulation of mitotic sister chromatid segregation|
|negative regulation of sister chromatid segregation|
|negative regulation of chromosome segregation|
|Cul3-RING ubiquitin ligase complex|
|regulation of TORC1 signaling|
|positive regulation of TOR signaling|
|negative regulation of mitotic nuclear division|
|negative regulation of nuclear division|
|regulation of mitotic metaphase/anaphase transition|
|regulation of metaphase/anaphase transition of cell cycle|
|regulation of mitotic sister chromatid separation|
|protein monoubiquitination|
|regulation of chromosome separation|
|regulation of mitotic sister chromatid segregation|
|cellular response to amino acid stimulus|
|mitotic spindle|
|regulation of sister chromatid segregation|
|negative regulation of autophagy|
|regulation of TOR signaling|
|regulation of chromosome segregation|
|mitotic sister chromatid segregation|
|response to amino acid|
|negative regulation of chromosome organization|
|sister chromatid segregation|
|mitotic nuclear division|
|mitotic cell cycle checkpoint|
|positive regulation of cell growth|
|regulation of mitotic nuclear division|
|regulation of nuclear division|
|cell cycle checkpoint|
|cellular response to acid chemical|
|negative regulation of mitotic cell cycle phase transition|
|nuclear chromosome segregation|
|negative regulation of cell cycle phase transition|
|lysosome|
|negative regulation of cellular catabolic process|
|positive regulation of growth|
|chromosome segregation|
|nuclear division|
|negative regulation of mitotic cell cycle|
|negative regulation of catabolic process|
|organelle fission|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|negative regulation of cell cycle process|
|regulation of autophagy|
|response to acid chemical|
|proteasomal protein catabolic process|
|regulation of chromosome organization|
|post-translational protein modification|
|negative regulation of organelle organization|
|regulation of mitotic cell cycle phase transition|
|regulation of cell growth|
|regulation of cell cycle phase transition|
|centrosome|
|cell division|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|negative regulation of cell cycle|
|proteolysis involved in cellular protein catabolic process|
|mitotic cell cycle process|
|cellular response to organonitrogen compound|
|cellular protein catabolic process|
|regulation of mitotic cell cycle|
|cellular response to nitrogen compound|
|regulation of growth|
|mitotic cell cycle|
|protein catabolic process|
|protein ubiquitination|
|negative regulation of cellular component organization|
|regulation of cell cycle process|
|protein modification by small protein conjugation|
|regulation of cellular catabolic process|
|cellular macromolecule catabolic process|
|protein modification by small protein conjugation or removal|
|regulation of catabolic process|
|cell cycle process|
|response to organonitrogen compound|
|positive regulation of intracellular signal transduction|
|macromolecule catabolic process|
|cellular response to oxygen-containing compound|
|organonitrogen compound catabolic process|
|chromosome organization|
|response to nitrogen compound|
|regulation of cell cycle|
|cellular response to endogenous stimulus|
|proteolysis|
|regulation of organelle organization|
|cell cycle|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|positive regulation of signal transduction|
|organic substance catabolic process|
|cellular catabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp33|Rotenone 2μM R00 exp33]]|-1.88|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|1/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12006
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.61 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KLHL22 Expression in NALM6 Cells: 2.61'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>