======= KPNA6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KPNA6
  * **<color #00a2e8>Official Name</color>**: karyopherin subunit alpha 6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23633|23633]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O60684|O60684]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KPNA6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KPNA6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610563|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. {ECO:0000269|PubMed:10523667}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Arm|
|IBB|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|entry of viral genome into host nucleus through nuclear pore complex via importin|
|evasion or tolerance of host defense response|
|evasion or tolerance of defense response of other organism involved in symbiotic interaction|
|evasion or tolerance by virus of host immune response|
|evasion or tolerance of immune response of other organism involved in symbiotic interaction|
|evasion or tolerance of host immune response|
|viral penetration into host nucleus|
|multi-organism nuclear import|
|evasion or tolerance of host defenses by virus|
|evasion or tolerance of defenses of other organism involved in symbiotic interaction|
|avoidance of host defenses|
|avoidance of defenses of other organism involved in symbiotic interaction|
|response to immune response of other organism involved in symbiotic interaction|
|evasion or tolerance of host defenses|
|response to host immune response|
|multi-organism cellular localization|
|multi-organism intracellular transport|
|response to host defenses|
|response to host|
|response to defenses of other organism involved in symbiotic interaction|
|NLS-bearing protein import into nucleus|
|positive regulation of cytokine production involved in inflammatory response|
|nuclear import signal receptor activity|
|nuclear localization sequence binding|
|regulation of defense response to virus by virus|
|modulation by virus of host morphology or physiology|
|regulation of cytokine production involved in inflammatory response|
|modification by symbiont of host morphology or physiology|
|intracellular transport of virus|
|host cell|
|transport of virus|
|positive regulation of viral life cycle|
|maternal process involved in female pregnancy|
|multi-organism localization|
|multi-organism transport|
|nuclear pore|
|protein import into nucleus|
|positive regulation of viral process|
|modification of morphology or physiology of other organism involved in symbiotic interaction|
|import into nucleus|
|positive regulation of inflammatory response|
|protein import|
|regulation of viral life cycle|
|modification of morphology or physiology of other organism|
|interaction with host|
|protein localization to nucleus|
|female pregnancy|
|viral life cycle|
|regulation of viral process|
|multi-multicellular organism process|
|regulation of symbiosis, encompassing mutualism through parasitism|
|nucleocytoplasmic transport|
|nuclear transport|
|regulation of inflammatory response|
|establishment of protein localization to organelle|
|positive regulation of cytokine production|
|positive regulation of defense response|
|positive regulation of multi-organism process|
|positive regulation of response to external stimulus|
|regulation of cytokine production|
|viral process|
|protein localization to organelle|
|regulation of defense response|
|regulation of multi-organism process|
|symbiotic process|
|interspecies interaction between organisms|
|multicellular organismal reproductive process|
|multicellular organism reproduction|
|multi-organism reproductive process|
|intracellular protein transport|
|regulation of response to external stimulus|
|positive regulation of transcription by RNA polymerase II|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|reproductive process|
|reproduction|
|regulation of response to stress|
|protein transport|
|intracellular transport|
|peptide transport|
|positive regulation of transcription, DNA-templated|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|establishment of localization in cell|
|nitrogen compound transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|membrane|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|-2.72|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|-1.91|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|-1.74|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|1.71|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|2.15|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|2.21|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:aff1|AFF1]]|0.412|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|1/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5985
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.01 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KPNA6 Expression in NALM6 Cells: 7.01'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>