======= KPNA7 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KPNA7
  * **<color #00a2e8>Official Name</color>**: karyopherin subunit alpha 7
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=402569|402569]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/A9QM74|A9QM74]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KPNA7&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KPNA7|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/614107|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC), which consists of 60-100 proteins. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion while larger molecules are transported by an active process. The protein encoded by this gene belongs to the importin alpha family, and is involved in nuclear protein import, but exhibits different nuclear localization signal binding specificity compared to other members of the family. A pseudogene of this gene has been defined on chromosome 5. [provided by RefSeq, Jul 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Functions in nuclear protein import. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|IBB|
|Arm|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of histone H3-K27 trimethylation|
|regulation of histone H3-K27 trimethylation|
|positive regulation of histone H3-K27 methylation|
|regulation of histone H3-K27 methylation|
|modulation by virus of host cellular process|
|nuclear import signal receptor activity|
|modulation by symbiont of host cellular process|
|modulation by virus of host morphology or physiology|
|positive regulation of histone methylation|
|modification by symbiont of host morphology or physiology|
|regulation of histone methylation|
|positive regulation of histone modification|
|protein import into nucleus|
|blastocyst development|
|positive regulation of chromatin organization|
|modification of morphology or physiology of other organism involved in symbiotic interaction|
|import into nucleus|
|spindle|
|protein import|
|regulation of histone modification|
|modification of morphology or physiology of other organism|
|interaction with host|
|protein localization to nucleus|
|positive regulation of chromosome organization|
|regulation of chromatin organization|
|nucleocytoplasmic transport|
|nuclear transport|
|regulation of chromosome organization|
|in utero embryonic development|
|establishment of protein localization to organelle|
|positive regulation of organelle organization|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|viral process|
|protein localization to organelle|
|symbiotic process|
|interspecies interaction between organisms|
|embryo development|
|intracellular protein transport|
|positive regulation of cellular component organization|
|positive regulation of protein modification process|
|regulation of organelle organization|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|establishment of localization in cell|
|regulation of protein modification process|
|nitrogen compound transport|
|positive regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp449|Arsenic trioxide 60μM R08 exp449]]|-1.79|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|1/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3427
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KPNA7 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>