======= KRT18 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KRT18
  * **<color #00a2e8>Official Name</color>**: keratin 18
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3875|3875]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P05783|P05783]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KRT18&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KRT18|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/148070|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  KRT18 encodes the type I intermediate filament chain keratin 18. Keratin 18, together with its filament partner keratin 8, are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection. {ECO:0000250, ECO:0000269|PubMed:15529338, ECO:0000269|PubMed:16424149, ECO:0000269|PubMed:17213200, ECO:0000269|PubMed:7523419, ECO:0000269|PubMed:8522591, ECO:0000269|PubMed:9298992, ECO:0000269|PubMed:9524113}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Filament|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Golgi to plasma membrane CFTR protein transport|
|hepatocyte apoptotic process|
|cadherin binding involved in cell-cell adhesion|
|epithelial cell apoptotic process|
|centriolar satellite|
|Golgi to plasma membrane protein transport|
|cell periphery|
|intermediate filament cytoskeleton organization|
|intermediate filament-based process|
|establishment of protein localization to plasma membrane|
|scaffold protein binding|
|Golgi to plasma membrane transport|
|vesicle-mediated transport to the plasma membrane|
|extrinsic apoptotic signaling pathway|
|keratin filament|
|post-Golgi vesicle-mediated transport|
|cell-cell adherens junction|
|cornification|
|intermediate filament|
|tumor necrosis factor-mediated signaling pathway|
|microtubule organizing center|
|protein localization to plasma membrane|
|structural molecule activity|
|protein localization to cell periphery|
|keratinization|
|cellular response to tumor necrosis factor|
|response to tumor necrosis factor|
|establishment of protein localization to membrane|
|keratinocyte differentiation|
|apoptotic signaling pathway|
|epidermal cell differentiation|
|Golgi vesicle transport|
|skin development|
|epidermis development|
|protein localization to membrane|
|cell-cell adhesion|
|cytokine-mediated signaling pathway|
|epithelial cell differentiation|
|perinuclear region of cytoplasm|
|viral process|
|symbiotic process|
|interspecies interaction between organisms|
|nucleolus|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|apoptotic process|
|cell adhesion|
|biological adhesion|
|negative regulation of cell death|
|cellular response to cytokine stimulus|
|programmed cell death|
|cell death|
|response to cytokine|
|cytoskeleton organization|
|epithelium development|
|cell cycle|
|RNA binding|
|protein transport|
|peptide transport|
|regulation of apoptotic process|
|regulation of programmed cell death|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|regulation of cell death|
|tissue development|
|nitrogen compound transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13258
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.87 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KRT18 Expression in NALM6 Cells: 0.87'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>