======= KRT78 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KRT78
  * **<color #00a2e8>Official Name</color>**: keratin 78
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=196374|196374]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8N1N4|Q8N1N4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KRT78&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KRT78|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611159|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is a member of the type II keratin gene family and encodes a protein with an intermediate filament domain. Keratins are the major structural proteins in epithelial cells, forming a cytoplasmic network of 10 to 12 nm wide intermediate filaments and creating a scaffold that gives cells the ability to withstand mechanical and non-mechanical stresses. The genes of the type II keratin family are located as a gene cluster at 12p13.13. Four pseudogenes of this gene family have been identified. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Filament|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|keratin filament|
|cornification|
|keratinization|
|keratinocyte differentiation|
|epidermal cell differentiation|
|skin development|
|epidermis development|
|epithelial cell differentiation|
|programmed cell death|
|cell death|
|epithelium development|
|extracellular space|
|tissue development|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|-1.9|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|-1.73|
|[[:results:exp332|Adefovir 20μM R07 exp332]]|1.8|
|[[:results:exp345|Cidofovir 10μM R07 exp345]]|1.82|
|[[:results:exp480|ETC-159 50μM R08 exp480]]|1.88|
|[[:results:exp58|UM131593 0.1μM R01 exp58]]|1.98|
|[[:results:exp176|Apcin 50 to 100μM on day4 R04 exp176]]|2.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:polr2j3|POLR2J3]]|0.553|
|[[:human genes:t:tceb3c|TCEB3C]]|0.548|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.543|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.515|
|[[:human genes:s:supt5h|SUPT5H]]|0.514|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.514|
|[[:human genes:p:paf1|PAF1]]|0.509|
|[[:human genes:v:vasn|VASN]]|0.501|
|[[:human genes:p:pola2|POLA2]]|0.501|
|[[:human genes:p:psmb4|PSMB4]]|0.501|
|[[:human genes:r:rad51|RAD51]]|0.5|
|[[:human genes:u:utp3|UTP3]]|0.497|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.496|
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.495|
|[[:human genes:t:tsg101|TSG101]]|0.492|
|[[:human genes:t:ticrr|TICRR]]|0.49|
|[[:human genes:g:golga8o|GOLGA8O]]|0.488|
|[[:human genes:p:psma6|PSMA6]]|0.488|
|[[:human genes:s:slc4a1|SLC4A1]]|0.486|
|[[:human genes:a:atp6v1a|ATP6V1A]]|0.486|
|[[:human genes:e:exosc9|EXOSC9]]|0.484|
|[[:human genes:c:cdca3|CDCA3]]|0.484|
|[[:human genes:c:ccna2|CCNA2]]|0.483|
|[[:human genes:c:col2a1|COL2A1]]|0.481|
|[[:human genes:s:supt6h|SUPT6H]]|0.481|
|[[:human genes:p:psmb2|PSMB2]]|0.479|
|[[:human genes:m:mphosph10|MPHOSPH10]]|0.478|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.476|
|[[:human genes:r:rpl35|RPL35]]|0.475|
|[[:human genes:c:cgb2|CGB2]]|0.475|
|[[:human genes:i:ik|IK]]|0.474|
|[[:human genes:r:rpl6|RPL6]]|0.473|
|[[:human genes:n:nupl1|NUPL1]]|0.473|
|[[:human genes:h:hap1|HAP1]]|0.471|
|[[:human genes:c:c14orf93|C14orf93]]|0.47|
|[[:human genes:p:psmb3|PSMB3]]|0.469|
|[[:human genes:p:plk1|PLK1]]|0.468|
|[[:human genes:m:mcoln1|MCOLN1]]|0.467|
|[[:human genes:a:atp6v0c|ATP6V0C]]|0.466|
|[[:human genes:o:orc6|ORC6]]|0.466|
|[[:human genes:p:prim1|PRIM1]]|0.466|
|[[:human genes:p:pole|POLE]]|0.463|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.462|
|[[:human genes:t:twistnb|TWISTNB]]|0.462|
|[[:human genes:r:rpl10a|RPL10A]]|0.458|
|[[:human genes:r:rrp7a|RRP7A]]|0.458|
|[[:human genes:u:upf1|UPF1]]|0.456|
|[[:human genes:a:aqr|AQR]]|0.456|
|[[:human genes:c:ccdc116|CCDC116]]|0.454|
|[[:human genes:n:ndc80|NDC80]]|0.454|
|[[:human genes:n:npipb5|NPIPB5]]|0.454|
|[[:human genes:s:strn|STRN]]|0.452|
|[[:human genes:c:cbwd3|CBWD3]]|0.452|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.451|
|[[:human genes:t:tp53tg3b|TP53TG3B]]|0.451|
|[[:human genes:t:tp53tg3|TP53TG3]]|0.45|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.45|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.45|
|[[:human genes:e:exosc6|EXOSC6]]|0.449|
|[[:human genes:t:tp53tg3c|TP53TG3C]]|0.449|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.449|
|[[:human genes:p:psmd3|PSMD3]]|0.446|
|[[:human genes:p:ppm1d|PPM1D]]|0.446|
|[[:human genes:c:cactin|CACTIN]]|0.446|
|[[:human genes:d:dido1|DIDO1]]|0.445|
|[[:human genes:c:cdc45|CDC45]]|0.445|
|[[:human genes:m:mdn1|MDN1]]|0.445|
|[[:human genes:c:cbwd5|CBWD5]]|0.445|
|[[:human genes:r:rps7|RPS7]]|0.444|
|[[:human genes:f:fam25b|FAM25B]]|0.444|
|[[:human genes:p:polr2a|POLR2A]]|0.444|
|[[:human genes:t:timeless|TIMELESS]]|0.444|
|[[:human genes:r:rps19bp1|RPS19BP1]]|0.443|
|[[:human genes:s:syt9|SYT9]]|0.443|
|[[:human genes:n:nup160|NUP160]]|0.442|
|[[:human genes:h:hivep3|HIVEP3]]|0.442|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.441|
|[[:human genes:p:parp3|PARP3]]|0.441|
|[[:human genes:o:or10g3|OR10G3]]|0.441|
|[[:human genes:t:tspy1|TSPY1]]|0.439|
|[[:human genes:i:iscu|ISCU]]|0.439|
|[[:human genes:a:ankle2|ANKLE2]]|0.439|
|[[:human genes:m:mbtd1|MBTD1]]|0.438|
|[[:human genes:b:bysl|BYSL]]|0.438|
|[[:human genes:x:xab2|XAB2]]|0.438|
|[[:human genes:s:slc6a17|SLC6A17]]|0.437|
|[[:human genes:n:napa|NAPA]]|0.436|
|[[:human genes:r:rps5|RPS5]]|0.435|
|[[:human genes:n:npipb8|NPIPB8]]|0.435|
|[[:human genes:n:nol12|NOL12]]|0.433|
|[[:human genes:p:prpf8|PRPF8]]|0.433|
|[[:human genes:a:ankle1|ANKLE1]]|0.433|
|[[:human genes:r:ranbp2|RANBP2]]|0.432|
|[[:human genes:s:sh3bp1|SH3BP1]]|0.431|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.431|
|[[:human genes:a:atp1a3|ATP1A3]]|0.429|
|[[:human genes:c:cope|COPE]]|0.429|
|[[:human genes:a:aatf|AATF]]|0.429|
|[[:human genes:p:ppfia4|PPFIA4]]|0.428|
|[[:human genes:n:nol9|NOL9]]|0.428|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.427|
|[[:human genes:r:rps2|RPS2]]|0.427|
|[[:human genes:r:rrp15|RRP15]]|0.426|
|[[:human genes:s:sart1|SART1]]|0.426|
|[[:human genes:r:rad21|RAD21]]|0.425|
|[[:human genes:s:snip1|SNIP1]]|0.425|
|[[:human genes:x:xylt2|XYLT2]]|0.425|
|[[:human genes:c:cbwd6|CBWD6]]|0.425|
|[[:human genes:r:rps9|RPS9]]|0.424|
|[[:human genes:c:ctr9|CTR9]]|0.424|
|[[:human genes:k:krt2|KRT2]]|0.424|
|[[:human genes:r:rpl7l1|RPL7L1]]|0.424|
|[[:human genes:o:oxer1|OXER1]]|0.423|
|[[:human genes:p:pola1|POLA1]]|0.423|
|[[:human genes:v:vps28|VPS28]]|0.423|
|[[:human genes:z:znf655|ZNF655]]|0.423|
|[[:human genes:r:rps3a|RPS3A]]|0.423|
|[[:human genes:d:dock6|DOCK6]]|0.422|
|[[:human genes:n:nup43|NUP43]]|0.422|
|[[:human genes:z:zfand5|ZFAND5]]|0.422|
|[[:human genes:a:arcn1|ARCN1]]|0.422|
|[[:human genes:p:psmd2|PSMD2]]|0.422|
|[[:human genes:t:tspy8|TSPY8]]|0.421|
|[[:human genes:n:nol10|NOL10]]|0.421|
|[[:human genes:c:chaf1a|CHAF1A]]|0.421|
|[[:human genes:r:riok2|RIOK2]]|0.419|
|[[:human genes:c:cdc73|CDC73]]|0.419|
|[[:human genes:a:atp6ap1|ATP6AP1]]|0.418|
|[[:human genes:n:nup205|NUP205]]|0.417|
|[[:human genes:g:gid4|GID4]]|0.416|
|[[:human genes:t:tfip11|TFIP11]]|0.416|
|[[:human genes:c:ccdc64b|CCDC64B]]|0.415|
|[[:human genes:a:add2|ADD2]]|0.415|
|[[:human genes:w:wdr87|WDR87]]|0.414|
|[[:human genes:c:copg1|COPG1]]|0.414|
|[[:human genes:c:cdca5|CDCA5]]|0.414|
|[[:human genes:h:hist1h4b|HIST1H4B]]|0.413|
|[[:human genes:m:mdm2|MDM2]]|0.413|
|[[:human genes:c:chd4|CHD4]]|0.413|
|[[:human genes:r:rpl9|RPL9]]|0.413|
|[[:human genes:m:mt1e|MT1E]]|0.413|
|[[:human genes:w:wdr75|WDR75]]|0.412|
|[[:human genes:s:snrpa1|SNRPA1]]|0.411|
|[[:human genes:r:rilpl2|RILPL2]]|0.41|
|[[:human genes:e:exosc5|EXOSC5]]|0.41|
|[[:human genes:s:ssh2|SSH2]]|0.41|
|[[:human genes:c:cdh24|CDH24]]|0.409|
|[[:human genes:n:narfl|NARFL]]|0.409|
|[[:human genes:p:pan3|PAN3]]|0.409|
|[[:human genes:g:golga6l3|GOLGA6L3]]|0.407|
|[[:human genes:c:copb2|COPB2]]|0.407|
|[[:human genes:m:mtch2|MTCH2]]|0.406|
|[[:human genes:o:orc1|ORC1]]|0.406|
|[[:human genes:n:nsf|NSF]]|0.406|
|[[:human genes:c:cox8a|COX8A]]|0.406|
|[[:human genes:p:pde4dip|PDE4DIP]]|0.406|
|[[:human genes:r:rplp1|RPLP1]]|0.405|
|[[:human genes:p:psmc2|PSMC2]]|0.405|
|[[:human genes:d:dnttip2|DNTTIP2]]|0.405|
|[[:human genes:g:golga8j|GOLGA8J]]|0.405|
|[[:human genes:p:pdcd11|PDCD11]]|0.405|
|[[:human genes:r:rpl34|RPL34]]|0.405|
|[[:human genes:l:lrr1|LRR1]]|0.405|
|[[:human genes:r:rbbp5|RBBP5]]|0.404|
|[[:human genes:s:scaf1|SCAF1]]|0.404|
|[[:human genes:t:trappc11|TRAPPC11]]|0.404|
|[[:human genes:h:hist2h3a|HIST2H3A]]|0.404|
|[[:human genes:h:hist2h3c|HIST2H3C]]|0.403|
|[[:human genes:n:nup153|NUP153]]|0.403|
|[[:human genes:m:mcf2l|MCF2L]]|0.402|
|[[:human genes:p:polr2d|POLR2D]]|0.402|
|[[:human genes:a:atp6v1b2|ATP6V1B2]]|0.402|
|[[:human genes:t:trim52|TRIM52]]|0.401|
|[[:human genes:p:pigs|PIGS]]|0.401|
|[[:human genes:c:copb1|COPB1]]|0.401|
|[[:human genes:p:psmd11|PSMD11]]|0.4|
|[[:human genes:p:pan2|PAN2]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1883
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -6.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KRT78 Expression in NALM6 Cells: -6.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>