======= L3MBTL3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: L3MBTL3
  * **<color #00a2e8>Official Name</color>**: L3MBTL histone methyl-lysine binding protein 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=84456|84456]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96JM7|Q96JM7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=L3MBTL3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20L3MBTL3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/618844|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the malignant brain tumor (MBT) family of chromatin interacting transcriptional repressors. Members of this family function as methyl-lysine readers, which recognize methylated lysine residues on histone protein tails, and are associated with the repression of gene expression. The encoded protein may regulate hematopoiesis. Homozygous deletion of this gene has been observed in human patients with medulloblastoma. [provided by RefSeq, Oct 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Required for normal maturation of myeloid progenitor cells (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|MBT|
|SAM 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|erythrocyte maturation|
|granulocyte differentiation|
|macrophage differentiation|
|erythrocyte development|
|myeloid cell development|
|erythrocyte differentiation|
|erythrocyte homeostasis|
|myeloid cell homeostasis|
|myeloid leukocyte differentiation|
|anatomical structure maturation|
|cell maturation|
|homeostasis of number of cells|
|myeloid cell differentiation|
|developmental maturation|
|leukocyte differentiation|
|hemopoiesis|
|hematopoietic or lymphoid organ development|
|immune system development|
|DNA-binding transcription factor activity|
|chromatin organization|
|molecular function|
|zinc ion binding|
|nucleolus|
|chromosome organization|
|homeostatic process|
|cell development|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|-1.92|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|-1.87|
|[[:results:exp82|Torin1 0.08μM R02 exp82]]|-1.86|
|[[:results:exp362|GSK-J4 1μM R07 exp362]]|-1.73|
|[[:results:exp528|TGF-beta1 44ng/ml R08 exp528]]|1.72|
|[[:results:exp475|CyclicAMP 200μM R08 exp475]]|1.74|
|[[:results:exp538|ZLN024 50μM R08 exp538]]|1.76|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|1.87|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|1.92|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|1.95|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|2|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|2.06|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|2.2|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|2.31|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|2.31|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|2.32|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|2.42|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|3.19|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11637
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.73 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='L3MBTL3 Expression in NALM6 Cells: 3.73'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>