======= LATS1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LATS1
  * **<color #00a2e8>Official Name</color>**: large tumor suppressor kinase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9113|9113]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O95835|O95835]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LATS1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LATS1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603473|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint. Negatively regulates G2/M transition by down-regulating CDK1 kinase activity. Involved in the control of p53 expression. Affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1. May also play a role in endocrine function. Plays a role in mammary gland epithelial cells differentiation, both through the Hippo signaling pathway and the intracellular estrogen receptor signaling pathway by promoting the degradation of ESR1 (PubMed:28068668). {ECO:0000269|PubMed:10518011, ECO:0000269|PubMed:10831611, ECO:0000269|PubMed:15122335, ECO:0000269|PubMed:15220930, ECO:0000269|PubMed:18158288, ECO:0000269|PubMed:19927127, ECO:0000269|PubMed:28068668}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase Tyr|
|Pkinase C|
|UBA|
|Pkinase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|inner cell mass cell fate commitment|
|inner cell mass cellular morphogenesis|
|inner cell mass cell differentiation|
|mammary gland epithelial cell differentiation|
|cytoplasmic sequestering of protein|
|hippo signaling|
|negative regulation of cyclin-dependent protein serine/threonine kinase activity|
|negative regulation of cyclin-dependent protein kinase activity|
|blastocyst formation|
|regulation of intracellular estrogen receptor signaling pathway|
|estrogen receptor binding|
|mammary gland epithelium development|
|regulation of intracellular steroid hormone receptor signaling pathway|
|regulation of organ growth|
|blastocyst development|
|regulation of cyclin-dependent protein serine/threonine kinase activity|
|regulation of cyclin-dependent protein kinase activity|
|positive regulation of peptidyl-serine phosphorylation|
|maintenance of protein location|
|G1/S transition of mitotic cell cycle|
|cell cycle G1/S phase transition|
|spindle pole|
|mammary gland development|
|G2/M transition of mitotic cell cycle|
|cell cycle G2/M phase transition|
|negative regulation of protein serine/threonine kinase activity|
|regulation of peptidyl-serine phosphorylation|
|sister chromatid segregation|
|regulation of ubiquitin-dependent protein catabolic process|
|microtubule organizing center|
|maintenance of location|
|regulation of actin filament polymerization|
|hormone-mediated signaling pathway|
|negative regulation of canonical Wnt signaling pathway|
|peptidyl-serine phosphorylation|
|regulation of actin polymerization or depolymerization|
|regulation of actin filament length|
|peptidyl-serine modification|
|negative regulation of Wnt signaling pathway|
|magnesium ion binding|
|regulation of proteolysis involved in cellular protein catabolic process|
|nuclear chromosome segregation|
|regulation of protein polymerization|
|negative regulation of protein kinase activity|
|cell fate commitment|
|negative regulation of kinase activity|
|regulation of cellular protein catabolic process|
|regulation of actin filament organization|
|mitotic cell cycle phase transition|
|keratinocyte differentiation|
|chromosome segregation|
|negative regulation of transferase activity|
|cell cycle phase transition|
|regulation of canonical Wnt signaling pathway|
|epidermal cell differentiation|
|regulation of developmental growth|
|regulation of actin cytoskeleton organization|
|regulation of supramolecular fiber organization|
|regulation of Wnt signaling pathway|
|protein serine/threonine kinase activity|
|regulation of cellular component size|
|in utero embryonic development|
|skin development|
|regulation of protein catabolic process|
|regulation of actin filament-based process|
|negative regulation of protein phosphorylation|
|gland development|
|epidermis development|
|negative regulation of phosphorylation|
|regulation of protein complex assembly|
|protein kinase binding|
|cell division|
|regulation of anatomical structure size|
|regulation of protein serine/threonine kinase activity|
|regulation of cytoskeleton organization|
|cell morphogenesis involved in differentiation|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|embryonic morphogenesis|
|negative regulation of cell cycle|
|negative regulation of protein modification process|
|mitotic cell cycle process|
|cellular response to hormone stimulus|
|chordate embryonic development|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|embryo development ending in birth or egg hatching|
|regulation of growth|
|epithelial cell differentiation|
|mitotic cell cycle|
|positive regulation of cell death|
|cell morphogenesis|
|regulation of proteolysis|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|cellular component morphogenesis|
|regulation of cellular catabolic process|
|regulation of kinase activity|
|peptidyl-amino acid modification|
|anatomical structure formation involved in morphogenesis|
|response to hormone|
|regulation of cellular component biogenesis|
|protein phosphorylation|
|regulation of transferase activity|
|embryo development|
|regulation of catabolic process|
|cell cycle process|
|positive regulation of protein phosphorylation|
|negative regulation of cellular protein metabolic process|
|positive regulation of phosphorylation|
|chromosome organization|
|negative regulation of protein metabolic process|
|epithelium development|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|negative regulation of molecular function|
|regulation of cell cycle|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|phosphorylation|
|regulation of organelle organization|
|cell cycle|
|negative regulation of cell communication|
|negative regulation of signaling|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|ATP binding|
|regulation of apoptotic process|
|regulation of programmed cell death|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|cell development|
|regulation of cell death|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|tissue development|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|-2.16|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|-1.9|
|[[:results:exp449|Arsenic trioxide 60μM R08 exp449]]|-1.77|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9674
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.89 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LATS1 Expression in NALM6 Cells: 5.89'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>