======= LCK =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LCK
  * **<color #00a2e8>Official Name</color>**: LCK proto-oncogene, Src family tyrosine kinase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3932|3932]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P06239|P06239]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LCK&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LCK|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/153390|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules. Multiple alternatively spliced variants encoding different isoforms have been described. [provided by RefSeq, Aug 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SH3 2|
|SH3 1|
|Pkinase|
|Pkinase Tyr|
|SH2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|CD8 receptor binding|
|T cell receptor binding|
|CD4 receptor binding|
|positive regulation of T cell receptor signaling pathway|
|positive regulation of heterotypic cell-cell adhesion|
|phosphatidylinositol 3-kinase binding|
|pericentriolar material|
|positive regulation of antigen receptor-mediated signaling pathway|
|regulation of heterotypic cell-cell adhesion|
|regulation of defense response to virus by virus|
|peptidyl-tyrosine autophosphorylation|
|cellular zinc ion homeostasis|
|SH2 domain binding|
|zinc ion homeostasis|
|immunological synapse|
|regulation of T cell receptor signaling pathway|
|phosphotyrosine residue binding|
|non-membrane spanning protein tyrosine kinase activity|
|T cell costimulation|
|lymphocyte costimulation|
|release of sequestered calcium ion into cytosol|
|negative regulation of sequestering of calcium ion|
|positive regulation of intrinsic apoptotic signaling pathway|
|extrinsic component of cytoplasmic side of plasma membrane|
|regulation of antigen receptor-mediated signaling pathway|
|protein serine/threonine phosphatase activity|
|calcium ion transmembrane import into cytosol|
|calcium ion transport into cytosol|
|ATPase binding|
|protein phosphatase binding|
|activation of cysteine-type endopeptidase activity involved in apoptotic process|
|protein tyrosine kinase activity|
|cytosolic calcium ion transport|
|cellular transition metal ion homeostasis|
|regulation of sequestering of calcium ion|
|B cell receptor signaling pathway|
|transition metal ion homeostasis|
|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|T cell differentiation|
|platelet activation|
|peptidyl-tyrosine phosphorylation|
|peptidyl-tyrosine modification|
|positive regulation of cysteine-type endopeptidase activity|
|regulation of intrinsic apoptotic signaling pathway|
|positive regulation of protein kinase B signaling|
|positive regulation of endopeptidase activity|
|positive regulation of apoptotic signaling pathway|
|T cell receptor signaling pathway|
|protein C-terminus binding|
|positive regulation of peptidase activity|
|protein autophosphorylation|
|calcium ion transmembrane transport|
|positive regulation of T cell activation|
|protein dephosphorylation|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|positive regulation of leukocyte cell-cell adhesion|
|regulation of protein kinase B signaling|
|membrane raft|
|T cell activation|
|lymphocyte differentiation|
|regulation of cysteine-type endopeptidase activity|
|calcium ion transport|
|positive regulation of cell-cell adhesion|
|positive regulation of cytosolic calcium ion concentration|
|blood coagulation|
|coagulation|
|antigen receptor-mediated signaling pathway|
|divalent metal ion transport|
|regulation of leukocyte cell-cell adhesion|
|hemostasis|
|divalent inorganic cation transport|
|dephosphorylation|
|regulation of T cell activation|
|regulation of cytosolic calcium ion concentration|
|leukocyte differentiation|
|signaling receptor binding|
|positive regulation of proteolysis|
|positive regulation of lymphocyte activation|
|leukocyte migration|
|lymphocyte activation|
|regulation of apoptotic signaling pathway|
|regulation of cell-cell adhesion|
|positive regulation of cell adhesion|
|positive regulation of leukocyte activation|
|regulation of endopeptidase activity|
|positive regulation of cell activation|
|cellular calcium ion homeostasis|
|regulation of peptidase activity|
|immune response-activating cell surface receptor signaling pathway|
|calcium ion homeostasis|
|protein kinase binding|
|cellular divalent inorganic cation homeostasis|
|wound healing|
|immune response-regulating cell surface receptor signaling pathway|
|divalent inorganic cation homeostasis|
|regulation of body fluid levels|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|regulation of lymphocyte activation|
|cellular metal ion homeostasis|
|hemopoiesis|
|inorganic cation transmembrane transport|
|immune response-activating signal transduction|
|response to wounding|
|immune response-regulating signaling pathway|
|regulation of leukocyte activation|
|hematopoietic or lymphoid organ development|
|cation transmembrane transport|
|metal ion homeostasis|
|activation of immune response|
|cellular cation homeostasis|
|metal ion transport|
|regulation of cell activation|
|positive regulation of apoptotic process|
|cellular ion homeostasis|
|inorganic ion transmembrane transport|
|immune system development|
|positive regulation of programmed cell death|
|regulation of cell adhesion|
|positive regulation of cell death|
|viral process|
|cation homeostasis|
|enzyme linked receptor protein signaling pathway|
|inorganic ion homeostasis|
|regulation of proteolysis|
|cellular chemical homeostasis|
|positive regulation of hydrolase activity|
|symbiotic process|
|ion homeostasis|
|interspecies interaction between organisms|
|cation transport|
|positive regulation of immune response|
|peptidyl-amino acid modification|
|cellular homeostasis|
|leukocyte activation|
|ion transmembrane transport|
|cell migration|
|protein phosphorylation|
|positive regulation of intracellular signal transduction|
|response to drug|
|identical protein binding|
|cell activation|
|localization of cell|
|cell motility|
|chemical homeostasis|
|regulation of immune response|
|positive regulation of immune system process|
|transmembrane transport|
|regulation of hydrolase activity|
|phosphorylation|
|locomotion|
|ion transport|
|positive regulation of catalytic activity|
|ATP binding|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|regulation of programmed cell death|
|positive regulation of cellular protein metabolic process|
|homeostatic process|
|positive regulation of signal transduction|
|regulation of immune system process|
|regulation of cell death|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp426|FBS-Wisent 0.1 R07 exp426]]|-1.72|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|1.71|
|[[:results:exp423|Zebularine 20μM R07 exp423]]|1.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9313
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.59 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LCK Expression in NALM6 Cells: 3.59'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>