======= LGI4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LGI4
  * **<color #00a2e8>Official Name</color>**: leucine rich repeat LGI family member 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=163175|163175]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8N135|Q8N135]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LGI4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LGI4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608303|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of Schwann cell signaling pathway(s) that controls axon segregation and myelin formation (By similarity). {ECO:0000250|UniProtKB:Q8K1S1}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|EPTP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|glial cell proliferation|
|peripheral nervous system axon ensheathment|
|myelination in peripheral nervous system|
|Schwann cell development|
|Schwann cell differentiation|
|neuron maturation|
|regulation of myelination|
|peripheral nervous system development|
|adult locomotory behavior|
|myelination|
|glial cell development|
|axon ensheathment|
|ensheathment of neurons|
|anatomical structure maturation|
|adult behavior|
|cell maturation|
|glial cell differentiation|
|locomotory behavior|
|gliogenesis|
|developmental maturation|
|cell population proliferation|
|behavior|
|neuron development|
|regulation of nervous system development|
|neuron differentiation|
|generation of neurons|
|extracellular space|
|neurogenesis|
|cell development|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|-2.64|
|[[:results:exp83|Trametinib 10μM R02 exp83]]|-1.84|
|[[:results:exp453|B02 10μM R08 exp453]]|-1.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.481|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8386
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.85 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LGI4 Expression in NALM6 Cells: -1.85'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>