======= LIG1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LIG1
  * **<color #00a2e8>Official Name</color>**: DNA ligase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3978|3978]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P18858|P18858]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LIG1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LIG1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/126391|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the ATP-dependent DNA ligase protein family. The encoded protein functions in DNA replication, recombination, and the base excision repair process. Mutations in this gene that lead to DNA ligase I deficiency result in immunodeficiency and increased sensitivity to DNA-damaging agents. Disruption of this gene may also be associated with a variety of cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DNA ligase A M|
|DNA ligase A N|
|DNA ligase A C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Okazaki fragment processing involved in mitotic DNA replication|
|DNA replication, Okazaki fragment processing|
|DNA ligase activity|
|DNA ligase (ATP) activity|
|lagging strand elongation|
|DNA ligation involved in DNA repair|
|mitotic DNA replication|
|DNA ligation|
|V(D)J recombination|
|DNA strand elongation involved in DNA replication|
|DNA strand elongation|
|nucleotide-excision repair, DNA gap filling|
|mismatch repair|
|somatic diversification of immune receptors via germline recombination within a single locus|
|somatic cell DNA recombination|
|base-excision repair|
|nuclear DNA replication|
|cell cycle DNA replication|
|somatic diversification of immune receptors|
|transcription-coupled nucleotide-excision repair|
|DNA biosynthetic process|
|nucleotide-excision repair|
|DNA-dependent DNA replication|
|DNA replication|
|DNA recombination|
|cell division|
|DNA repair|
|mitotic cell cycle process|
|immune system development|
|mitotic cell cycle|
|intracellular membrane-bounded organelle|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|cell cycle process|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|mitochondrion|
|organic cyclic compound biosynthetic process|
|cell cycle|
|DNA binding|
|ATP binding|
|cellular nitrogen compound biosynthetic process|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|-2.28|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|-1.84|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|-1.83|
|[[:results:exp331|A-769662 20μM R07 exp331]]|-1.76|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|-1.73|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|1.7|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|1.74|
|[[:results:exp73|LJH685 5μM R02 exp73]]|1.74|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|1.75|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|1.75|
|[[:results:exp283|Glyphosate 1000μM R06 exp283]]|1.77|
|[[:results:exp417|Tubastatin-A 2.5μM R07 exp417]]|1.84|
|[[:results:exp90|WYE-354 6μM R02 exp90]]|1.93|
|[[:results:exp310|2-Methoxyestradiol 0.55μM R07 exp310]]|2.02|
|[[:results:exp303|39°C R06 exp303]]|2.04|
|[[:results:exp332|Adefovir 20μM R07 exp332]]|2.08|
|[[:results:exp209|Deguelin 0.15μM R05 exp209]]|2.32|
|[[:results:exp235|Geldanamycin 0.01μM R05 exp235]]|2.41|
|[[:results:exp423|Zebularine 20μM R07 exp423]]|2.53|
|[[:results:exp72|LB-100 4.1μM R02 exp72]]|2.67|
|[[:results:exp340|BN82002 4μM R07 exp340]]|2.8|
|[[:results:exp359|FK-506 30μM R07 exp359]]|2.86|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|2.9|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|2.98|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:e:eme1|EME1]]|0.435|
|[[:human genes:p:piwil1|PIWIL1]]|0.416|
|[[:human genes:b:brd8|BRD8]]|0.414|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 4/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|2/26|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|1/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 381
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.95 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LIG1 Expression in NALM6 Cells: 6.95'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>