======= LIMK1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LIMK1
  * **<color #00a2e8>Official Name</color>**: LIM domain kinase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3984|3984]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P53667|P53667]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LIMK1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LIMK1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601329|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is a serine/threonine kinase that regulates actin polymerization via phosphorylation and inactivation of the actin binding factor cofilin. This protein is ubiquitously expressed during development and plays a role in many cellular processes associated with cytoskeletal structure. This protein also stimulates axon growth and may play a role in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Feb 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase Tyr|
|LIM|
|Pkinase|
|Kdo|
|PDZ|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of ubiquitin-protein transferase activity|
|positive regulation of axon extension|
|positive regulation of stress fiber assembly|
|regulation of ubiquitin-protein transferase activity|
|heat shock protein binding|
|positive regulation of actin filament bundle assembly|
|negative regulation of protein ubiquitination|
|Rho protein signal transduction|
|regulation of stress fiber assembly|
|negative regulation of protein modification by small protein conjugation or removal|
|positive regulation of axonogenesis|
|regulation of actomyosin structure organization|
|regulation of actin filament bundle assembly|
|regulation of axon extension|
|regulation of extent of cell growth|
|immune response-regulating cell surface receptor signaling pathway involved in phagocytosis|
|Fc-gamma receptor signaling pathway involved in phagocytosis|
|Fc receptor mediated stimulatory signaling pathway|
|Fc-gamma receptor signaling pathway|
|positive regulation of cell morphogenesis involved in differentiation|
|positive regulation of cell growth|
|positive regulation of developmental growth|
|lamellipodium|
|regulation of cell size|
|regulation of axonogenesis|
|positive regulation of supramolecular fiber organization|
|regulation of protein ubiquitination|
|positive regulation of cytoskeleton organization|
|regulation of protein modification by small protein conjugation or removal|
|protein kinase activity|
|Fc receptor signaling pathway|
|Ras protein signal transduction|
|positive regulation of growth|
|regulation of actin filament organization|
|negative regulation of transferase activity|
|positive regulation of neuron projection development|
|regulation of cell morphogenesis involved in differentiation|
|small GTPase mediated signal transduction|
|neuron projection|
|regulation of developmental growth|
|phagocytosis|
|regulation of actin cytoskeleton organization|
|regulation of supramolecular fiber organization|
|protein serine/threonine kinase activity|
|positive regulation of neuron differentiation|
|regulation of cellular component size|
|positive regulation of cell projection organization|
|regulation of actin filament-based process|
|nuclear speck|
|focal adhesion|
|regulation of cell growth|
|immune response-activating cell surface receptor signaling pathway|
|positive regulation of neurogenesis|
|immune response-regulating cell surface receptor signaling pathway|
|protein heterodimerization activity|
|regulation of cell morphogenesis|
|actin cytoskeleton organization|
|regulation of neuron projection development|
|regulation of anatomical structure size|
|positive regulation of cellular component biogenesis|
|positive regulation of nervous system development|
|regulation of cytoskeleton organization|
|positive regulation of cell development|
|immune response-activating signal transduction|
|actin filament-based process|
|negative regulation of protein modification process|
|immune response-regulating signaling pathway|
|positive regulation of organelle organization|
|activation of immune response|
|regulation of neuron differentiation|
|regulation of growth|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|negative regulation of catalytic activity|
|regulation of neurogenesis|
|positive regulation of immune response|
|regulation of nervous system development|
|regulation of cell development|
|regulation of cellular component biogenesis|
|positive regulation of cell differentiation|
|protein phosphorylation|
|regulation of transferase activity|
|negative regulation of cellular protein metabolic process|
|regulation of anatomical structure morphogenesis|
|immune effector process|
|negative regulation of protein metabolic process|
|cytoskeleton organization|
|negative regulation of molecular function|
|positive regulation of immune system process|
|regulation of immune response|
|positive regulation of cellular component organization|
|phosphorylation|
|regulation of organelle organization|
|positive regulation of developmental process|
|ATP binding|
|generation of neurons|
|neurogenesis|
|regulation of immune system process|
|intracellular signal transduction|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|regulation of protein modification process|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp177|Apcin 25μM plus proTAME 2μM R04 exp177]]|-1.78|
|[[:results:exp316|Geldanamycin 0.015 to 0.025μM on day4 R07 exp316]]|1.81|
|[[:results:exp537|WNT3A 44ng/ml R08 exp537]]|1.9|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16350
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.09 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LIMK1 Expression in NALM6 Cells: 5.09'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>