======= LIMS1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LIMS1
  * **<color #00a2e8>Official Name</color>**: LIM zinc finger domain containing 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3987|3987]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P48059|P48059]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LIMS1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LIMS1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602567|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Adapter protein in a cytoplasmic complex linking beta- integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. Involved in the regulation of cell survival, cell proliferation and cell differentiation.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|LIM|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of integrin-mediated signaling pathway|
|regulation of integrin-mediated signaling pathway|
|positive regulation of focal adhesion assembly|
|positive regulation of adherens junction organization|
|positive regulation of cell junction assembly|
|positive regulation of substrate adhesion-dependent cell spreading|
|positive regulation of cell-matrix adhesion|
|regulation of substrate adhesion-dependent cell spreading|
|regulation of focal adhesion assembly|
|regulation of cell-substrate junction assembly|
|cell aging|
|regulation of adherens junction organization|
|epithelial to mesenchymal transition|
|positive regulation of NIK/NF-kappaB signaling|
|regulation of cell junction assembly|
|protein heterooligomerization|
|regulation of NIK/NF-kappaB signaling|
|regulation of cell-matrix adhesion|
|tumor necrosis factor-mediated signaling pathway|
|positive regulation of cell-substrate adhesion|
|cell-cell junction organization|
|cellular response to transforming growth factor beta stimulus|
|positive regulation of cell morphogenesis involved in differentiation|
|mesenchymal cell differentiation|
|response to transforming growth factor beta|
|cell junction assembly|
|cell-cell junction|
|regulation of cell-substrate adhesion|
|cell junction organization|
|mesenchyme development|
|cellular response to tumor necrosis factor|
|response to tumor necrosis factor|
|aging|
|regulation of cell morphogenesis involved in differentiation|
|regulation of epithelial cell proliferation|
|positive regulation of cell adhesion|
|positive regulation of GTPase activity|
|focal adhesion|
|protein kinase binding|
|regulation of GTPase activity|
|regulation of cell morphogenesis|
|cellular response to growth factor stimulus|
|cell-cell adhesion|
|protein complex oligomerization|
|positive regulation of cellular component biogenesis|
|response to growth factor|
|positive regulation of cell development|
|protein-containing complex|
|cytokine-mediated signaling pathway|
|regulation of cell adhesion|
|perinuclear region of cytoplasm|
|positive regulation of hydrolase activity|
|zinc ion binding|
|cell adhesion|
|regulation of cell development|
|biological adhesion|
|regulation of cellular component biogenesis|
|positive regulation of cell differentiation|
|cellular response to cytokine stimulus|
|positive regulation of intracellular signal transduction|
|regulation of anatomical structure morphogenesis|
|response to cytokine|
|negative regulation of transcription, DNA-templated|
|positive regulation of cellular component organization|
|cellular response to endogenous stimulus|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|regulation of hydrolase activity|
|negative regulation of RNA metabolic process|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|positive regulation of catalytic activity|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|protein-containing complex assembly|
|establishment of protein localization|
|regulation of cell population proliferation|
|positive regulation of signal transduction|
|negative regulation of gene expression|
|tissue development|
|positive regulation of molecular function|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|protein-containing complex subunit organization|
|positive regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp340|BN82002 4μM R07 exp340]]|1.73|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 8/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|4/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17670
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.89 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LIMS1 Expression in NALM6 Cells: 5.89'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>