======= LIPA =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LIPA
  * **<color #00a2e8>Official Name</color>**: lipase A, lysosomal acid type
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3988|3988]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P38571|P38571]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LIPA&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LIPA|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/613497|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes lipase A, the lysosomal acid lipase (also known as cholesterol ester hydrolase). This enzyme functions in the lysosome to catalyze the hydrolysis of cholesteryl esters and triglycerides. Mutations in this gene can result in Wolman disease and cholesteryl ester storage disease. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Crucial for the intracellular hydrolysis of cholesteryl esters and triglycerides that have been internalized via receptor- mediated endocytosis of lipoprotein particles. Important in mediating the effect of LDL (low density lipoprotein) uptake on suppression of hydroxymethylglutaryl-CoA reductase and activation of endogenous cellular cholesteryl ester formation.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Abhydrolase 1|
|Abhydro lipase|
|Abhydrolase 5|
|Abhydrolase 6|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|sterol esterase activity|
|lipase activity|
|low-density lipoprotein particle clearance|
|homeostasis of number of cells within a tissue|
|plasma lipoprotein particle clearance|
|regulation of plasma lipoprotein particle levels|
|lysosomal lumen|
|tissue remodeling|
|fibrillar center|
|sterol metabolic process|
|cytokine production|
|lung development|
|respiratory tube development|
|tissue homeostasis|
|respiratory system development|
|homeostasis of number of cells|
|lysosome|
|steroid metabolic process|
|lipid catabolic process|
|multicellular organismal homeostasis|
|anatomical structure homeostasis|
|organic hydroxy compound metabolic process|
|inflammatory response|
|cell population proliferation|
|intracellular membrane-bounded organelle|
|cell morphogenesis|
|cellular component morphogenesis|
|tube development|
|cellular lipid metabolic process|
|lipid metabolic process|
|defense response|
|homeostatic process|
|organic substance catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|-2.79|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|-2.33|
|[[:results:exp245|UM0011500 5μM R05 exp245]]|-2.25|
|[[:results:exp53|Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53]]|-1.85|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|1.77|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|1.82|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|2.15|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:commd5|COMMD5]]|0.444|
|[[:human genes:v:vps41|VPS41]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9098
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.23 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LIPA Expression in NALM6 Cells: 6.23'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>