======= LOH12CR1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: BORCS5
  * **<color #00a2e8>Official Name</color>**: BLOC-1 related complex subunit 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=118426|118426]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q969J3|Q969J3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LOH12CR1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LOH12CR1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616598|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor. Thereby, it may indirectly play a role in cell spreading and motility. {ECO:0000269|PubMed:25898167}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|LOH1CR12|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of synaptic vesicle transport|
|positive regulation of anterograde synaptic vesicle transport|
|plus-end kinesin complex|
|regulation of anterograde synaptic vesicle transport|
|positive regulation of vesicle transport along microtubule|
|regulation of vesicle transport along microtubule|
|cytoplasmic side of lysosomal membrane|
|regulation of synaptic vesicle transport|
|BORC complex|
|regulation of organelle transport along microtubule|
|intrinsic component of membrane|
|regulation of microtubule-based movement|
|lysosome localization|
|synaptic vesicle membrane|
|organelle transport along microtubule|
|transport along microtubule|
|cytoskeleton-dependent intracellular transport|
|microtubule-based transport|
|positive regulation of intracellular transport|
|regulation of microtubule-based process|
|microtubule-based movement|
|regulation of intracellular transport|
|establishment of organelle localization|
|positive regulation of cellular component movement|
|organelle localization|
|microtubule-based process|
|regulation of cellular localization|
|positive regulation of transport|
|regulation of cellular component movement|
|intracellular transport|
|movement of cell or subcellular component|
|establishment of localization in cell|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|1.77|
|[[:results:exp269|Bisphenol A 100μM R06 exp269]]|1.8|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12944
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.42 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LOH12CR1 Expression in NALM6 Cells: 3.42'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>