======= LRP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LRP1
  * **<color #00a2e8>Official Name</color>**: LDL receptor related protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4035|4035]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q07954|Q07954]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LRP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LRP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/107770|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the low-density lipoprotein receptor family of proteins. The encoded preproprotein is proteolytically processed by furin to generate 515 kDa and 85 kDa subunits that form the mature receptor (PMID: 8546712). This receptor is involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the alpha 2-macroglobulin-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer's disease patients. [provided by RefSeq, Oct 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early embryonic development. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission (PubMed:11907044, PubMed:12888553, PubMed:12713657). Acts as an alpha-2- macroglobulin receptor (PubMed:26142438). {ECO:0000269|PubMed:11907044, ECO:0000269|PubMed:12713657, ECO:0000269|PubMed:12888553, ECO:0000269|PubMed:26142438}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ldl recept b|
|cEGF|
|Ldl recept a|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|alpha-2 macroglobulin receptor activity|
|positive regulation of cholesterol import|
|apolipoprotein receptor activity|
|positive regulation of collateral sprouting of injured axon|
|positive regulation of sterol import|
|regulation of collateral sprouting of injured axon|
|positive regulation of Schwann cell migration|
|positive regulation of sprouting of injured axon|
|positive regulation of axon extension involved in regeneration|
|regulation of Schwann cell migration|
|regulation of axon extension involved in regeneration|
|lipoprotein particle receptor binding|
|regulation of sprouting of injured axon|
|positive regulation of lysosomal protein catabolic process|
|regulation of chemokine (C-C motif) ligand 2 secretion|
|regulation of sterol import|
|positive regulation of chemokine (C-C motif) ligand 2 secretion|
|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|
|regulation of cholesterol import|
|chemoattraction of axon|
|astrocyte activation involved in immune response|
|positive regulation of protein catabolic process in the vacuole|
|amyloid-beta clearance by transcytosis|
|amyloid-beta clearance by cellular catabolic process|
|positive regulation of amyloid-beta clearance|
|positive regulation of axon regeneration|
|regulation of platelet-derived growth factor receptor-beta signaling pathway|
|regulation of lysosomal protein catabolic process|
|plasma membrane protein complex|
|clathrin heavy chain binding|
|insulin-responsive compartment|
|positive regulation of glial cell migration|
|positive regulation of neuron projection regeneration|
|positive regulation of chemokine (C-X-C motif) ligand 2 production|
|regulation of protein catabolic process in the vacuole|
|positive regulation of collateral sprouting|
|regulation of chemokine (C-X-C motif) ligand 2 production|
|lipoprotein localization|
|regulation of phospholipase A2 activity|
|negative regulation of cytosolic calcium ion concentration|
|lipoprotein transport|
|low-density lipoprotein particle receptor activity|
|negative regulation of platelet-derived growth factor receptor signaling pathway|
|cargo receptor activity|
|positive regulation of chemokine secretion|
|regulation of glial cell migration|
|regulation of amyloid-beta clearance|
|apolipoprotein binding|
|regulation of extracellular matrix disassembly|
|regulation of chemokine secretion|
|heparan sulfate proteoglycan binding|
|positive regulation of cholesterol efflux|
|positive regulation of vascular associated smooth muscle cell migration|
|negative regulation of focal adhesion assembly|
|transcytosis|
|astrocyte activation|
|regulation of collateral sprouting|
|negative regulation of adherens junction organization|
|regulation of vascular associated smooth muscle cell migration|
|negative regulation of smooth muscle cell migration|
|amyloid-beta clearance|
|regulation of platelet-derived growth factor receptor signaling pathway|
|positive regulation of sterol transport|
|negative regulation of cell junction assembly|
|positive regulation of cholesterol transport|
|regulation of cholesterol efflux|
|regulation of axon regeneration|
|axonal growth cone|
|aorta morphogenesis|
|protein kinase C-activating G protein-coupled receptor signaling pathway|
|regulation of neuron projection regeneration|
|positive regulation of insulin secretion involved in cellular response to glucose stimulus|
|coreceptor activity|
|astrocyte development|
|positive regulation of smooth muscle cell migration|
|regulation of extracellular matrix organization|
|negative regulation of cell-matrix adhesion|
|glial cell activation|
|apoptotic cell clearance|
|cellular response to amyloid-beta|
|neuroinflammatory response|
|positive regulation of axon extension|
|regulation of cholesterol transport|
|regulation of sterol transport|
|positive chemotaxis|
|response to amyloid-beta|
|scavenger receptor activity|
|aorta development|
|astrocyte differentiation|
|clathrin-coated pit|
|positive regulation of protein localization to plasma membrane|
|positive regulation of chemokine production|
|clathrin-coated vesicle|
|regulation of insulin secretion involved in cellular response to glucose stimulus|
|regulation of smooth muscle cell migration|
|regulation of focal adhesion assembly|
|regulation of cell-substrate junction assembly|
|positive regulation of lipid transport|
|artery morphogenesis|
|receptor internalization|
|positive regulation of protein localization to cell periphery|
|negative regulation of cell-substrate adhesion|
|positive regulation of response to wounding|
|regulation of adherens junction organization|
|positive regulation of phagocytosis|
|endocytic vesicle membrane|
|positive regulation of gliogenesis|
|apical part of cell|
|regulation of phospholipase activity|
|positive regulation of insulin secretion|
|regulation of chemokine production|
|positive regulation of lipid localization|
|amyloid-beta binding|
|artery development|
|positive regulation of axonogenesis|
|regulation of cell junction assembly|
|positive regulation of protein binding|
|regulation of protein localization to plasma membrane|
|regulation of phagocytosis|
|positive regulation of peptide hormone secretion|
|regulation of axon extension|
|regulation of lipase activity|
|positive regulation of endocytosis|
|protease binding|
|retinoid metabolic process|
|receptor metabolic process|
|lysosomal transport|
|glial cell development|
|regulation of lipid transport|
|diterpenoid metabolic process|
|regulation of extent of cell growth|
|regulation of cell-matrix adhesion|
|regulation of protein localization to cell periphery|
|regulation of gliogenesis|
|cerebral cortex development|
|lipoprotein metabolic process|
|terpenoid metabolic process|
|positive regulation of protein localization to membrane|
|positive regulation of hormone secretion|
|regulation of lipid localization|
|isoprenoid metabolic process|
|positive regulation of cytokine secretion|
|positive regulation of cellular protein catabolic process|
|vacuolar transport|
|negative regulation of neuron apoptotic process|
|negative regulation of neuron projection development|
|positive regulation of cell morphogenesis involved in differentiation|
|positive regulation of cell growth|
|regulation of response to wounding|
|glial cell differentiation|
|positive regulation of developmental growth|
|pallium development|
|positive regulation of binding|
|regulation of insulin secretion|
|negative regulation of cell projection organization|
|regulation of cell size|
|regulation of axonogenesis|
|regulation of protein localization to membrane|
|cellular lipid catabolic process|
|basolateral plasma membrane|
|receptor complex|
|regulation of cytokine secretion|
|signaling receptor activity|
|regulation of endocytosis|
|negative regulation of neuron death|
|regulation of neuron apoptotic process|
|negative regulation of Wnt signaling pathway|
|regulation of peptide hormone secretion|
|regulation of cell-substrate adhesion|
|positive regulation of ERK1 and ERK2 cascade|
|gliogenesis|
|positive regulation of protein catabolic process|
|regulation of protein binding|
|negative regulation of neuron differentiation|
|receptor-mediated endocytosis|
|regulation of cellular protein catabolic process|
|early endosome|
|telencephalon development|
|negative regulation of cell migration|
|positive regulation of growth|
|axon guidance|
|neuron projection guidance|
|protein-containing complex binding|
|regulation of hormone secretion|
|positive regulation of protein secretion|
|negative regulation of cell adhesion|
|negative regulation of cell motility|
|aging|
|positive regulation of neuron projection development|
|positive regulation of cytosolic calcium ion concentration|
|positive regulation of peptide secretion|
|negative regulation of neurogenesis|
|regulation of ERK1 and ERK2 cascade|
|lipid catabolic process|
|lysosomal membrane|
|regulation of cell morphogenesis involved in differentiation|
|negative regulation of cellular component movement|
|regulation of neuron death|
|negative regulation of nervous system development|
|negative regulation of locomotion|
|positive regulation of cellular protein localization|
|cellular response to peptide|
|regulation of cytosolic calcium ion concentration|
|regulation of developmental growth|
|phagocytosis|
|negative regulation of cell development|
|regulation of actin cytoskeleton organization|
|regulation of Wnt signaling pathway|
|positive regulation of cellular catabolic process|
|positive regulation of neuron differentiation|
|neuronal cell body|
|axonogenesis|
|regulation of cellular component size|
|regulation of binding|
|positive regulation of cell projection organization|
|regulation of protein catabolic process|
|forebrain development|
|regulation of actin filament-based process|
|positive regulation of secretion by cell|
|blood vessel morphogenesis|
|axon development|
|focal adhesion|
|regulation of cell growth|
|dendrite|
|positive regulation of protein transport|
|cell morphogenesis involved in neuron differentiation|
|positive regulation of catabolic process|
|positive regulation of secretion|
|cellular calcium ion homeostasis|
|calcium ion homeostasis|
|positive regulation of cytokine production|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|cellular divalent inorganic cation homeostasis|
|positive regulation of neurogenesis|
|response to peptide|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|blood vessel development|
|cell projection morphogenesis|
|divalent inorganic cation homeostasis|
|regulation of cell morphogenesis|
|regulation of peptide secretion|
|regulation of neuron projection development|
|inflammatory response|
|positive regulation of cell migration|
|vasculature development|
|cell part morphogenesis|
|regulation of anatomical structure size|
|cardiovascular system development|
|positive regulation of cell motility|
|regulation of hormone levels|
|positive regulation of nervous system development|
|positive regulation of cellular component movement|
|regulation of cellular protein localization|
|regulation of cytoskeleton organization|
|positive regulation of cell development|
|positive regulation of MAPK cascade|
|regulation of vesicle-mediated transport|
|chemotaxis|
|positive regulation of locomotion|
|taxis|
|cell population proliferation|
|endocytosis|
|cell morphogenesis involved in differentiation|
|cellular metal ion homeostasis|
|cellular response to organonitrogen compound|
|positive regulation of response to external stimulus|
|metal ion homeostasis|
|cell activation involved in immune response|
|cellular cation homeostasis|
|cellular ion homeostasis|
|tube morphogenesis|
|regulation of neuron differentiation|
|cellular response to nitrogen compound|
|neuron projection development|
|regulation of growth|
|import into cell|
|regulation of cell adhesion|
|regulation of cytokine production|
|regulation of plasma membrane bounded cell projection organization|
|positive regulation of cell death|
|negative regulation of cellular component organization|
|regulation of protein transport|
|cation homeostasis|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|inorganic ion homeostasis|
|calcium ion binding|
|cell morphogenesis|
|regulation of cellular response to stress|
|regulation of peptide transport|
|brain development|
|cellular chemical homeostasis|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of MAPK cascade|
|head development|
|ion homeostasis|
|regulation of secretion|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|regulation of cellular catabolic process|
|tube development|
|regulation of cell migration|
|circulatory system development|
|negative regulation of apoptotic process|
|cellular homeostasis|
|negative regulation of programmed cell death|
|regulation of cell motility|
|regulation of cellular localization|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|cellular lipid metabolic process|
|regulation of cellular component biogenesis|
|positive regulation of cell differentiation|
|central nervous system development|
|regulation of locomotion|
|positive regulation of transport|
|negative regulation of cell death|
|regulation of catabolic process|
|regulation of cellular component movement|
|response to organonitrogen compound|
|neuron differentiation|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|regulation of protein localization|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|cell activation|
|response to nitrogen compound|
|immune effector process|
|regulation of response to external stimulus|
|chemical homeostasis|
|plasma membrane bounded cell projection organization|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|cell projection organization|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|lipid metabolic process|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|regulation of organelle organization|
|locomotion|
|G protein-coupled receptor signaling pathway|
|defense response|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|RNA binding|
|integral component of plasma membrane|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|regulation of response to stress|
|protein transport|
|generation of neurons|
|peptide transport|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|amide transport|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|negative regulation of response to stimulus|
|neurogenesis|
|homeostatic process|
|cell development|
|positive regulation of signal transduction|
|regulation of cell death|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|organic substance catabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|cellular catabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|nitrogen compound transport|
|regulation of protein modification process|
|regulation of transport|
|immune response|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|1.73|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9467
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.03 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LRP1 Expression in NALM6 Cells: 5.03'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>