======= LRP6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LRP6
  * **<color #00a2e8>Official Name</color>**: LDL receptor related protein 6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4040|4040]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75581|O75581]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LRP6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LRP6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603507|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.[provided by RefSeq, Dec 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor- ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3- mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation (By similarity). {ECO:0000250, ECO:0000269|PubMed:11357136, ECO:0000269|PubMed:11448771, ECO:0000269|PubMed:15778503, ECO:0000269|PubMed:16341017, ECO:0000269|PubMed:16513652, ECO:0000269|PubMed:17326769, ECO:0000269|PubMed:17400545, ECO:0000269|PubMed:19107203, ECO:0000269|PubMed:19293931, ECO:0000269|PubMed:19801552}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ldl recept a|
|Ldl recept b|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|canonical Wnt signaling pathway involved in neural crest cell differentiation|
|external genitalia morphogenesis|
|coreceptor activity involved in Wnt signaling pathway|
|coreceptor activity involved in canonical Wnt signaling pathway|
|receptor-mediated endocytosis involved in cholesterol transport|
|axis elongation involved in somitogenesis|
|Wnt-Frizzled-LRP5/6 complex|
|trachea cartilage morphogenesis|
|canonical Wnt signaling pathway involved in regulation of cell proliferation|
|Wnt signaling pathway involved in somitogenesis|
|kinase inhibitor activity|
|toxin transmembrane transporter activity|
|negative regulation of smooth muscle cell apoptotic process|
|embryonic retina morphogenesis in camera-type eye|
|trachea cartilage development|
|pericardium morphogenesis|
|midbrain-hindbrain boundary development|
|primitive streak formation|
|Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation|
|neural crest formation|
|trachea morphogenesis|
|midbrain dopaminergic neuron differentiation|
|rostrocaudal neural tube patterning|
|low-density lipoprotein particle receptor activity|
|Wnt signalosome|
|thalamus development|
|genitalia morphogenesis|
|convergent extension|
|apolipoprotein binding|
|intracellular cholesterol transport|
|cellular response to cholesterol|
|intracellular sterol transport|
|Wnt-activated receptor activity|
|trachea development|
|pericardium development|
|cellular response to sterol|
|beta-catenin destruction complex disassembly|
|branching involved in mammary gland duct morphogenesis|
|regulation of smooth muscle cell apoptotic process|
|response to cholesterol|
|embryonic camera-type eye morphogenesis|
|axis elongation|
|gastrulation with mouth forming second|
|cartilage morphogenesis|
|dopaminergic neuron differentiation|
|response to sterol|
|mammary gland duct morphogenesis|
|face morphogenesis|
|neural tube patterning|
|embryonic eye morphogenesis|
|intracellular lipid transport|
|head morphogenesis|
|embryonic camera-type eye development|
|Wnt-protein binding|
|cerebellum morphogenesis|
|negative regulation of muscle cell apoptotic process|
|toxin transport|
|frizzled binding|
|hindbrain morphogenesis|
|mammary gland morphogenesis|
|body morphogenesis|
|bone remodeling|
|genitalia development|
|face development|
|morphogenesis of an epithelial sheet|
|retina morphogenesis in camera-type eye|
|anterior/posterior axis specification|
|cholesterol transport|
|mammary gland epithelium development|
|embryonic pattern specification|
|somitogenesis|
|sterol transport|
|regulation of muscle cell apoptotic process|
|epithelial to mesenchymal transition|
|caveola|
|diencephalon development|
|somite development|
|odontogenesis of dentin-containing tooth|
|cellular response to alcohol|
|midbrain development|
|axis specification|
|neural crest cell differentiation|
|canonical Wnt signaling pathway|
|roof of mouth development|
|neural tube closure|
|tube closure|
|segmentation|
|primary neural tube formation|
|gland morphogenesis|
|tissue remodeling|
|cerebellum development|
|neural tube formation|
|metencephalon development|
|camera-type eye morphogenesis|
|bone morphogenesis|
|developmental growth involved in morphogenesis|
|cerebral cortex development|
|odontogenesis|
|embryonic epithelial tube formation|
|embryonic appendage morphogenesis|
|embryonic limb morphogenesis|
|mammary gland development|
|branching morphogenesis of an epithelial tube|
|epithelial tube formation|
|negative regulation of protein serine/threonine kinase activity|
|organic hydroxy compound transport|
|retina development in camera-type eye|
|morphogenesis of embryonic epithelium|
|eye morphogenesis|
|tube formation|
|limb morphogenesis|
|appendage morphogenesis|
|hindbrain development|
|early endosome membrane|
|mesenchymal cell differentiation|
|stem cell differentiation|
|gastrulation|
|morphogenesis of a branching epithelium|
|neural tube development|
|morphogenesis of a branching structure|
|cartilage development|
|pallium development|
|negative regulation of canonical Wnt signaling pathway|
|central nervous system neuron differentiation|
|limb development|
|appendage development|
|protein localization to plasma membrane|
|respiratory system development|
|bone development|
|negative regulation of Wnt signaling pathway|
|anterior/posterior pattern specification|
|mesenchyme development|
|connective tissue development|
|negative regulation of protein kinase activity|
|protein localization to cell periphery|
|response to alcohol|
|receptor-mediated endocytosis|
|skeletal system morphogenesis|
|protein-containing complex disassembly|
|negative regulation of kinase activity|
|cytoplasmic vesicle|
|early endosome|
|sensory organ morphogenesis|
|telencephalon development|
|positive regulation of DNA-binding transcription factor activity|
|sex differentiation|
|synapse|
|negative regulation of transferase activity|
|regulation of canonical Wnt signaling pathway|
|positive regulation of cytosolic calcium ion concentration|
|embryonic organ morphogenesis|
|lipid transport|
|epithelial tube morphogenesis|
|camera-type eye development|
|lipid localization|
|regulation of cytosolic calcium ion concentration|
|regionalization|
|signaling receptor binding|
|Wnt signaling pathway|
|cell-cell signaling by wnt|
|eye development|
|visual system development|
|regulation of Wnt signaling pathway|
|sensory system development|
|neuronal cell body|
|positive regulation of cell cycle|
|forebrain development|
|developmental growth|
|response to peptide hormone|
|growth|
|cellular component disassembly|
|negative regulation of protein phosphorylation|
|gland development|
|chemical synaptic transmission|
|anterograde trans-synaptic signaling|
|reproductive structure development|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|regulation of DNA-binding transcription factor activity|
|reproductive system development|
|morphogenesis of an epithelium|
|embryonic organ development|
|pattern specification process|
|cellular calcium ion homeostasis|
|trans-synaptic signaling|
|negative regulation of phosphorylation|
|calcium ion homeostasis|
|synaptic signaling|
|cellular divalent inorganic cation homeostasis|
|response to peptide|
|protein localization to membrane|
|divalent inorganic cation homeostasis|
|skeletal system development|
|cell-cell adhesion|
|regulation of protein serine/threonine kinase activity|
|cellular response to lipid|
|heart development|
|cellular response to organic cyclic compound|
|sensory organ development|
|cell population proliferation|
|endocytosis|
|cellular metal ion homeostasis|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|tissue morphogenesis|
|embryonic morphogenesis|
|negative regulation of protein modification process|
|cell surface|
|metal ion homeostasis|
|chordate embryonic development|
|cellular cation homeostasis|
|cellular ion homeostasis|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|developmental process involved in reproduction|
|import into cell|
|cation homeostasis|
|inorganic ion homeostasis|
|brain development|
|cellular chemical homeostasis|
|head development|
|ion homeostasis|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|tube development|
|response to lipid|
|circulatory system development|
|regulation of kinase activity|
|protein homodimerization activity|
|negative regulation of apoptotic process|
|anatomical structure formation involved in morphogenesis|
|cellular homeostasis|
|negative regulation of programmed cell death|
|response to hormone|
|response to organic cyclic compound|
|cell adhesion|
|biological adhesion|
|animal organ morphogenesis|
|regulation of transferase activity|
|embryo development|
|central nervous system development|
|Golgi apparatus|
|negative regulation of cell death|
|response to organonitrogen compound|
|endoplasmic reticulum|
|neuron differentiation|
|negative regulation of cellular protein metabolic process|
|cellular response to oxygen-containing compound|
|identical protein binding|
|response to nitrogen compound|
|negative regulation of protein metabolic process|
|chemical homeostasis|
|epithelium development|
|cell-cell signaling|
|negative regulation of molecular function|
|regulation of cell cycle|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|reproductive process|
|reproduction|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|intracellular transport|
|generation of neurons|
|regulation of apoptotic process|
|positive regulation of transcription, DNA-templated|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|regulation of cell death|
|positive regulation of RNA metabolic process|
|tissue development|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|establishment of localization in cell|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|extracellular region|
|vesicle-mediated transport|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp502|Milciclib 2μM R08 exp502]]|1.72|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|2.1|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|2.14|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11408
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.8 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LRP6 Expression in NALM6 Cells: 5.8'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>