======= LRRTM1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LRRTM1
  * **<color #00a2e8>Official Name</color>**: leucine rich repeat transmembrane neuronal 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=347730|347730]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q86UE6|Q86UE6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LRRTM1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LRRTM1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610867|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Exhibits strong synaptogenic activity, restricted to excitatory presynaptic differentiation, acting at both pre- and postsynaptic level. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|LRR 4|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of postsynaptic density assembly|
|negative regulation of receptor internalization|
|regulation of postsynapse assembly|
|regulation of postsynaptic specialization assembly|
|regulation of excitatory synapse assembly|
|regulation of postsynaptic density organization|
|negative regulation of receptor-mediated endocytosis|
|integral component of postsynaptic specialization membrane|
|exploration behavior|
|regulation of presynapse assembly|
|regulation of presynapse organization|
|excitatory synapse|
|negative regulation of endocytosis|
|long-term synaptic potentiation|
|regulation of receptor internalization|
|protein localization to synapse|
|positive regulation of synapse assembly|
|GABA-ergic synapse|
|regulation of postsynapse organization|
|regulation of receptor-mediated endocytosis|
|regulation of synapse assembly|
|growth cone|
|positive regulation of synaptic transmission|
|regulation of synaptic plasticity|
|locomotory behavior|
|regulation of endocytosis|
|regulation of synapse organization|
|regulation of organelle assembly|
|regulation of synapse structure or activity|
|extracellular matrix|
|synapse organization|
|axon|
|glutamatergic synapse|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|negative regulation of transport|
|positive regulation of cellular component biogenesis|
|positive regulation of nervous system development|
|cell junction|
|regulation of vesicle-mediated transport|
|behavior|
|cell surface|
|negative regulation of cellular component organization|
|molecular function|
|regulation of nervous system development|
|regulation of cellular component biogenesis|
|endoplasmic reticulum|
|positive regulation of cellular component organization|
|regulation of organelle organization|
|positive regulation of developmental process|
|extracellular space|
|positive regulation of multicellular organismal process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp333|All-trans-Retinoic-Acid 8μM R07 exp333]]|1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7846
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LRRTM1 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>