======= LSM11 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LSM11
  * **<color #00a2e8>Official Name</color>**: LSM11, U7 small nuclear RNA associated
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=134353|134353]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P83369|P83369]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LSM11&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LSM11|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617910|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|LSM|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|U7 snRNA binding|
|mRNA 3-end processing by stem-loop binding and cleavage|
|histone pre-mRNA 3end processing complex|
|U7 snRNP|
|telomerase holoenzyme complex|
|histone mRNA metabolic process|
|termination of RNA polymerase II transcription|
|positive regulation of G1/S transition of mitotic cell cycle|
|positive regulation of cell cycle G1/S phase transition|
|DNA-templated transcription, termination|
|positive regulation of mitotic cell cycle phase transition|
|mRNA 3-end processing|
|positive regulation of cell cycle phase transition|
|RNA 3-end processing|
|regulation of G1/S transition of mitotic cell cycle|
|positive regulation of mitotic cell cycle|
|regulation of cell cycle G1/S phase transition|
|nuclear body|
|positive regulation of cell cycle process|
|positive regulation of cell cycle|
|regulation of mitotic cell cycle phase transition|
|regulation of cell cycle phase transition|
|mRNA processing|
|transcription by RNA polymerase II|
|regulation of mitotic cell cycle|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|mRNA metabolic process|
|regulation of cell cycle process|
|RNA processing|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|regulation of cell cycle|
|organic cyclic compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp263|Aphidicolin 0.04μM R06 exp263]]|-2.18|
|[[:results:exp11|CCCP 1μM R00 exp11]]|-1.96|
|[[:results:exp453|B02 10μM R08 exp453]]|-1.86|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|1.92|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:thg1l|THG1L]]|0.567|
|[[:human genes:r:rptor|RPTOR]]|0.562|
|[[:human genes:u:uap1|UAP1]]|0.542|
|[[:human genes:d:dohh|DOHH]]|0.541|
|[[:human genes:g:gmppb|GMPPB]]|0.536|
|[[:human genes:e:exoc4|EXOC4]]|0.528|
|[[:human genes:a:atxn10|ATXN10]]|0.519|
|[[:human genes:p:pmm2|PMM2]]|0.514|
|[[:human genes:c:cbfb|CBFB]]|0.511|
|[[:human genes:u:uhrf1|UHRF1]]|0.509|
|[[:human genes:d:dpagt1|DPAGT1]]|0.504|
|[[:human genes:r:rtcb|RTCB]]|0.498|
|[[:human genes:g:gnb1l|GNB1L]]|0.491|
|[[:human genes:r:rnmt|RNMT]]|0.485|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.484|
|[[:human genes:a:atp5j|ATP5J]]|0.477|
|[[:human genes:g:gfpt1|GFPT1]]|0.471|
|[[:human genes:s:srp14|SRP14]]|0.469|
|[[:human genes:r:rpp21|RPP21]]|0.464|
|[[:human genes:t:tmem41b|TMEM41B]]|0.461|
|[[:human genes:p:ppcs|PPCS]]|0.459|
|[[:human genes:u:urm1|URM1]]|0.459|
|[[:human genes:p:pelo|PELO]]|0.458|
|[[:human genes:p:ppa2|PPA2]]|0.458|
|[[:human genes:t:ten1|TEN1]]|0.458|
|[[:human genes:a:alg1|ALG1]]|0.456|
|[[:human genes:a:alg13|ALG13]]|0.454|
|[[:human genes:a:alg2|ALG2]]|0.454|
|[[:human genes:t:triap1|TRIAP1]]|0.454|
|[[:human genes:p:ppp6c|PPP6C]]|0.453|
|[[:human genes:m:mtor|MTOR]]|0.452|
|[[:human genes:w:wdr59|WDR59]]|0.449|
|[[:human genes:t:tti2|TTI2]]|0.446|
|[[:human genes:n:nars|NARS]]|0.445|
|[[:human genes:t:tti1|TTI1]]|0.444|
|[[:human genes:t:tamm41|TAMM41]]|0.443|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.442|
|[[:human genes:t:ttc4|TTC4]]|0.441|
|[[:human genes:e:elac2|ELAC2]]|0.44|
|[[:human genes:h:hars|HARS]]|0.439|
|[[:human genes:f:fh|FH]]|0.439|
|[[:human genes:m:med16|MED16]]|0.438|
|[[:human genes:e:eif3f|EIF3F]]|0.436|
|[[:human genes:l:lmo2|LMO2]]|0.435|
|[[:human genes:d:dhps|DHPS]]|0.434|
|[[:human genes:q:qars|QARS]]|0.434|
|[[:human genes:a:adsl|ADSL]]|0.433|
|[[:human genes:e:elp2|ELP2]]|0.432|
|[[:human genes:u:ube2g2|UBE2G2]]|0.43|
|[[:human genes:t:trmt10a|TRMT10A]]|0.429|
|[[:human genes:s:ssb|SSB]]|0.429|
|[[:human genes:t:taz|TAZ]]|0.427|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.427|
|[[:human genes:n:n6amt1|N6AMT1]]|0.426|
|[[:human genes:h:haus8|HAUS8]]|0.424|
|[[:human genes:w:wdr24|WDR24]]|0.423|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.423|
|[[:human genes:v:vezt|VEZT]]|0.423|
|[[:human genes:d:dpf2|DPF2]]|0.421|
|[[:human genes:a:atp5a1|ATP5A1]]|0.419|
|[[:human genes:d:ddx1|DDX1]]|0.419|
|[[:human genes:s:slc25a26|SLC25A26]]|0.418|
|[[:human genes:d:dr1|DR1]]|0.416|
|[[:human genes:c:ccdc101|CCDC101]]|0.416|
|[[:human genes:c:chchd4|CHCHD4]]|0.416|
|[[:human genes:y:yars|YARS]]|0.416|
|[[:human genes:m:mapk14|MAPK14]]|0.414|
|[[:human genes:m:med23|MED23]]|0.414|
|[[:human genes:t:tsen34|TSEN34]]|0.414|
|[[:human genes:d:ddx20|DDX20]]|0.412|
|[[:human genes:l:lsm10|LSM10]]|0.412|
|[[:human genes:g:gemin8|GEMIN8]]|0.412|
|[[:human genes:m:mllt1|MLLT1]]|0.411|
|[[:human genes:d:dhrsx|DHRSX]]|0.409|
|[[:human genes:s:sec62|SEC62]]|0.409|
|[[:human genes:i:id3|ID3]]|0.409|
|[[:human genes:m:maml1|MAML1]]|0.405|
|[[:human genes:s:slc25a19|SLC25A19]]|0.405|
|[[:human genes:e:exoc3|EXOC3]]|0.403|
|[[:human genes:z:znf608|ZNF608]]|0.402|
|[[:human genes:p:pdap1|PDAP1]]|0.402|
|[[:human genes:c:cct7|CCT7]]|0.402|
|[[:human genes:t:trnt1|TRNT1]]|0.401|
|[[:human genes:m:mbtps2|MBTPS2]]|0.401|
|[[:human genes:r:rft1|RFT1]]|0.401|
|[[:human genes:u:utp23|UTP23]]|0.4|
|[[:human genes:s:snapc5|SNAPC5]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 49/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|0/28|
|bone|3/25|
|breast|3/33|
|central nervous system|5/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|1/20|
|lung|6/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|1/7|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|4/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1237
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.12 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LSM11 Expression in NALM6 Cells: 5.12'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>