======= LZTS3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LZTS3
  * **<color #00a2e8>Official Name</color>**: leucine zipper tumor suppressor family member 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9762|9762]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O60299|O60299]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LZTS3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LZTS3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610484|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May be involved in promoting the maturation of dendritic spines, probably via regulating SIPA1L1 levels at the postsynaptic density of synapses. {ECO:0000250|UniProtKB:Q8K1Q4}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Fez1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of dendritic spine morphogenesis|
|regulation of dendritic spine development|
|regulation of dendrite morphogenesis|
|regulation of postsynapse organization|
|regulation of dendrite development|
|postsynaptic membrane|
|regulation of synapse organization|
|regulation of synapse structure or activity|
|postsynaptic density|
|synapse|
|regulation of cell morphogenesis involved in differentiation|
|cytoskeleton|
|regulation of cell morphogenesis|
|regulation of neuron projection development|
|cell junction|
|regulation of neuron differentiation|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|regulation of neurogenesis|
|regulation of nervous system development|
|regulation of cell development|
|regulation of anatomical structure morphogenesis|
|generation of neurons|
|neurogenesis|
|regulation of cell differentiation|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp483|FTY720 3μM R08 exp483]]|-2.19|
|[[:results:exp417|Tubastatin-A 2.5μM R07 exp417]]|-2.17|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|-1.88|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|-1.81|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|-1.7|
|[[:results:exp401|SNS-032 25μM R07 exp401]]|1.76|
|[[:results:exp246|UM0011500 10μM R05 exp246]]|1.98|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17667
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.41 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LZTS3 Expression in NALM6 Cells: 1.41'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>