======= MAFB =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MAFB
  * **<color #00a2e8>Official Name</color>**: MAF bZIP transcription factor B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9935|9935]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y5Q3|Q9Y5Q3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MAFB&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MAFB|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608968|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a basic leucine zipper (bZIP) transcription factor that plays an important role in the regulation of lineage-specific hematopoiesis. The encoded nuclear protein represses ETS1-mediated transcription of erythroid-specific genes in myeloid cells. This gene contains no introns. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Acts as a transcriptional activator or repressor (PubMed:27181683). Plays a pivotal role in regulating lineage- specific hematopoiesis by repressing ETS1-mediated transcription of erythroid-specific genes in myeloid cells. Required for monocytic, macrophage, osteoclast, podocyte and islet beta cell differentiation. Involved in renal tubule survival and F4/80 maturation. Activates the insulin and glucagon promoters. Together with PAX6, transactivates weakly the glucagon gene promoter through the G1 element. SUMO modification controls its transcriptional activity and ability to specify macrophage fate. Binds element G1 on the glucagon promoter (By similarity). Involved either as an oncogene or as a tumor suppressor, depending on the cell context. {ECO:0000250|UniProtKB:P54841, ECO:0000269|PubMed:19143053, ECO:0000269|PubMed:27181683}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Maf N|
|bZIP Maf|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|rhombomere 6 development|
|abducens nerve morphogenesis|
|abducens nerve formation|
|abducens nerve development|
|brain segmentation|
|rhombomere 5 development|
|central nervous system segmentation|
|rhombomere development|
|cranial nerve formation|
|negative regulation of erythrocyte differentiation|
|segment specification|
|negative regulation of osteoclast differentiation|
|cranial nerve morphogenesis|
|respiratory gaseous exchange by respiratory system|
|thymus development|
|regulation of erythrocyte differentiation|
|negative regulation of myeloid leukocyte differentiation|
|T cell differentiation in thymus|
|cranial nerve development|
|regulation of osteoclast differentiation|
|negative regulation of myeloid cell differentiation|
|nerve development|
|segmentation|
|inner ear morphogenesis|
|negative regulation of leukocyte differentiation|
|regulation of myeloid leukocyte differentiation|
|ear morphogenesis|
|T cell differentiation|
|negative regulation of hemopoiesis|
|hindbrain development|
|inner ear development|
|transcription factor complex|
|ear development|
|regulation of myeloid cell differentiation|
|T cell activation|
|lymphocyte differentiation|
|sensory organ morphogenesis|
|regulation of leukocyte differentiation|
|embryonic organ morphogenesis|
|leukocyte differentiation|
|regionalization|
|transcription factor binding|
|lymphocyte activation|
|gland development|
|sequence-specific DNA binding|
|embryonic organ development|
|pattern specification process|
|negative regulation of immune system process|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|regulation of hemopoiesis|
|protein heterodimerization activity|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|sensory organ development|
|hemopoiesis|
|embryonic morphogenesis|
|hematopoietic or lymphoid organ development|
|immune system development|
|DNA-binding transcription factor activity|
|negative regulation of cell differentiation|
|brain development|
|head development|
|protein homodimerization activity|
|anatomical structure formation involved in morphogenesis|
|leukocyte activation|
|negative regulation of developmental process|
|animal organ morphogenesis|
|embryo development|
|central nervous system development|
|cell activation|
|negative regulation of multicellular organismal process|
|positive regulation of transcription by RNA polymerase II|
|positive regulation of transcription, DNA-templated|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|regulation of immune system process|
|positive regulation of RNA metabolic process|
|regulation of cell differentiation|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp537|WNT3A 44ng/ml R08 exp537]]|2.08|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.537|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9946
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -4.01 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MAFB Expression in NALM6 Cells: -4.01'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>