======= MAG =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MAG
  * **<color #00a2e8>Official Name</color>**: myelin associated glycoprotein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4099|4099]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P20916|P20916]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MAG&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MAG|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/159460|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a type I membrane protein and member of the immunoglobulin superfamily. It is thought to be involved in the process of myelination. It is a lectin that binds to sialylated glycoconjugates and mediates certain myelin-neuron cell-cell interactions. Three alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Nov 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Adhesion molecule that mediates interactions between myelinating cells and neurons by binding to neuronal sialic acid- containing gangliosides and to the glycoproteins RTN4R and RTN4RL2 (By similarity). Not required for initial myelination, but seems to play a role in the maintenance of normal axon myelination. Protects motoneurons against apoptosis, also after injury; protection against apoptosis is probably mediated via interaction with neuronal RTN4R and RTN4RL2. Required to prevent degeneration of myelinated axons in adults; this probably depends on binding to gangliosides on the axon cell membrane (By similarity). Negative regulator of neurite outgrowth; in dorsal root ganglion neurons the inhibition is mediated primarily via binding to neuronal RTN4R or RTN4RL2 and to a lesser degree via binding to neuronal gangliosides. In cerebellar granule cells the inhibition is mediated primarily via binding to neuronal gangliosides. In sensory neurons, inhibition of neurite extension depends only partially on RTN4R, RTN4RL2 and gangliosides. Inhibits axon longitudinal growth (By similarity). Inhibits axon outgrowth by binding to RTN4R (By similarity). Preferentially binds to alpha- 2,3-linked sialic acid. Binds ganglioside Gt1b (By similarity). {ECO:0000250|UniProtKB:P07722, ECO:0000250|UniProtKB:P20917}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|C2-set 2|
|I-set|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mesaxon|
|ganglioside GT1b binding|
|compact myelin|
|myelin sheath adaxonal region|
|Schmidt-Lanterman incisure|
|sialic acid binding|
|positive regulation of astrocyte differentiation|
|paranode region of axon|
|positive regulation of myelination|
|axon ensheathment in central nervous system|
|central nervous system myelination|
|axon regeneration|
|regulation of astrocyte differentiation|
|neuron projection regeneration|
|myelin sheath|
|positive regulation of glial cell differentiation|
|negative regulation of axon extension|
|oligodendrocyte development|
|regulation of myelination|
|response to axon injury|
|transmission of nerve impulse|
|positive regulation of nervous system process|
|positive regulation of gliogenesis|
|regulation of glial cell differentiation|
|negative regulation of axonogenesis|
|oligodendrocyte differentiation|
|cellular response to mechanical stimulus|
|regulation of axon extension|
|negative regulation of cell morphogenesis involved in differentiation|
|negative regulation of developmental growth|
|myelination|
|glial cell development|
|ensheathment of neurons|
|axon ensheathment|
|regulation of extent of cell growth|
|regulation of gliogenesis|
|multicellular organismal signaling|
|regulation of nervous system process|
|negative regulation of neuron apoptotic process|
|negative regulation of neuron projection development|
|regeneration|
|glial cell differentiation|
|carbohydrate binding|
|regulation of cell size|
|negative regulation of cell projection organization|
|negative regulation of cell growth|
|regulation of axonogenesis|
|negative regulation of neuron death|
|regulation of neuron apoptotic process|
|response to mechanical stimulus|
|gliogenesis|
|negative regulation of neuron differentiation|
|membrane raft|
|negative regulation of growth|
|cell-cell adhesion via plasma-membrane adhesion molecules|
|negative regulation of neurogenesis|
|regulation of cell morphogenesis involved in differentiation|
|regulation of neuron death|
|negative regulation of nervous system development|
|cellular response to abiotic stimulus|
|cellular response to environmental stimulus|
|regulation of developmental growth|
|negative regulation of cell development|
|cellular response to external stimulus|
|signaling receptor binding|
|regulation of cellular component size|
|leukocyte migration|
|axon development|
|regulation of cell growth|
|protein kinase binding|
|positive regulation of neurogenesis|
|regulation of cell morphogenesis|
|regulation of neuron projection development|
|cell-cell adhesion|
|regulation of anatomical structure size|
|positive regulation of nervous system development|
|positive regulation of cell development|
|response to wounding|
|regulation of system process|
|regulation of neuron differentiation|
|neuron projection development|
|regulation of growth|
|regulation of plasma membrane bounded cell projection organization|
|negative regulation of cellular component organization|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|neuron development|
|regulation of neurogenesis|
|protein homodimerization activity|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|regulation of nervous system development|
|cell adhesion|
|regulation of cell development|
|biological adhesion|
|negative regulation of developmental process|
|cell migration|
|positive regulation of cell differentiation|
|central nervous system development|
|negative regulation of cell death|
|neuron differentiation|
|regulation of anatomical structure morphogenesis|
|cell motility|
|localization of cell|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|response to abiotic stimulus|
|negative regulation of multicellular organismal process|
|locomotion|
|positive regulation of developmental process|
|nervous system process|
|integral component of plasma membrane|
|generation of neurons|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|regulation of programmed cell death|
|neurogenesis|
|cell development|
|regulation of cell death|
|cellular response to stress|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp210|LB-100 2μM R05 exp210]]|-1.74|
|[[:results:exp484|GSK-J5 1.5μM R08 exp484]]|1.85|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|1.93|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.415|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3054
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MAG Expression in NALM6 Cells: -1.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>