======= MB =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MB
  * **<color #00a2e8>Official Name</color>**: myoglobin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4151|4151]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P02144|P02144]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MB&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MB|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/160000|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the globin superfamily and is expressed in skeletal and cardiac muscles. The encoded protein is a haemoprotein contributing to intracellular oxygen storage and transcellular facilitated diffusion of oxygen. At least three alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Globin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|slow-twitch skeletal muscle fiber contraction|
|twitch skeletal muscle contraction|
|voluntary skeletal muscle contraction|
|enucleate erythrocyte differentiation|
|oxygen carrier activity|
|oxygen transport|
|gas transport|
|brown fat cell differentiation|
|skeletal muscle contraction|
|oxygen binding|
|multicellular organismal movement|
|musculoskeletal movement|
|erythrocyte differentiation|
|erythrocyte homeostasis|
|fat cell differentiation|
|myeloid cell homeostasis|
|striated muscle contraction|
|response to hydrogen peroxide|
|heme binding|
|drug transport|
|response to reactive oxygen species|
|homeostasis of number of cells|
|myeloid cell differentiation|
|muscle contraction|
|muscle system process|
|response to antibiotic|
|response to hypoxia|
|response to decreased oxygen levels|
|response to oxygen levels|
|response to oxidative stress|
|response to toxic substance|
|heart development|
|response to inorganic substance|
|hemopoiesis|
|hematopoietic or lymphoid organ development|
|immune system development|
|circulatory system development|
|response to hormone|
|response to drug|
|response to abiotic stimulus|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|homeostatic process|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp153|SGC2096 2.6μM R03 exp153]]|2.24|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11888
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -4.27 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MB Expression in NALM6 Cells: -4.27'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>