======= MBTD1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MBTD1
  * **<color #00a2e8>Official Name</color>**: mbt domain containing 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=54799|54799]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q05BQ5|Q05BQ5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MBTD1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MBTD1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/618705|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility (By similarity). Specifically binds to monomethylated and dimethylated 'Lys-20' on histone H4. {ECO:0000250, ECO:0000269|PubMed:19841675}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|MBT|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|methylated histone binding|
|embryonic skeletal system development|
|skeletal system development|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|chromatin organization|
|zinc ion binding|
|embryo development|
|chromosome organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|-2.81|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|-2.68|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|-2.4|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|-2.26|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|-2.17|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|-2.1|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|-2.08|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|-2.05|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|-2.01|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|-1.96|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|-1.86|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|-1.8|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|-1.79|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|-1.74|
|[[:results:exp134|MS023 2μM R03 exp134]]|-1.71|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|1.7|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|1.78|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|1.88|
|[[:results:exp453|B02 10μM R08 exp453]]|1.89|
|[[:results:exp133|MKC9989 10μM R03 exp133]]|1.89|
|[[:results:exp23|Nocodazole 0.02μM R00 exp23]]|1.98|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|2.03|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|2.11|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|2.18|
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|2.23|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|2.32|
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|2.37|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|2.8|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|3|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:i:ino80e|INO80E]]|0.506|
|[[:human genes:p:polr2a|POLR2A]]|0.487|
|[[:human genes:c:chd4|CHD4]]|0.486|
|[[:human genes:s:supt5h|SUPT5H]]|0.481|
|[[:human genes:t:tfpt|TFPT]]|0.479|
|[[:human genes:c:chchd3|CHCHD3]]|0.475|
|[[:human genes:z:zfand5|ZFAND5]]|0.472|
|[[:human genes:p:polr2j3|POLR2J3]]|0.466|
|[[:human genes:n:napa|NAPA]]|0.464|
|[[:human genes:e:exosc9|EXOSC9]]|0.463|
|[[:human genes:r:rps19bp1|RPS19BP1]]|0.453|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.448|
|[[:human genes:t:tspy8|TSPY8]]|0.448|
|[[:human genes:r:rpl35|RPL35]]|0.445|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.445|
|[[:human genes:x:xylt2|XYLT2]]|0.444|
|[[:human genes:p:polr2d|POLR2D]]|0.444|
|[[:human genes:p:psma6|PSMA6]]|0.444|
|[[:human genes:m:mtch2|MTCH2]]|0.444|
|[[:human genes:p:psmb4|PSMB4]]|0.443|
|[[:human genes:s:slc6a17|SLC6A17]]|0.44|
|[[:human genes:k:krt78|KRT78]]|0.438|
|[[:human genes:d:disp2|DISP2]]|0.436|
|[[:human genes:t:terf2|TERF2]]|0.435|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.435|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.434|
|[[:human genes:z:znf541|ZNF541]]|0.434|
|[[:human genes:t:ticrr|TICRR]]|0.434|
|[[:human genes:r:rrm1|RRM1]]|0.431|
|[[:human genes:c:cactin|CACTIN]]|0.431|
|[[:human genes:w:wdr43|WDR43]]|0.429|
|[[:human genes:n:nup93|NUP93]]|0.428|
|[[:human genes:p:pan2|PAN2]]|0.428|
|[[:human genes:o:ogfr|OGFR]]|0.426|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.425|
|[[:human genes:n:nfya|NFYA]]|0.425|
|[[:human genes:s:smg7|SMG7]]|0.424|
|[[:human genes:r:rpl35a|RPL35A]]|0.424|
|[[:human genes:s:sh3bp1|SH3BP1]]|0.424|
|[[:human genes:p:psmc1|PSMC1]]|0.42|
|[[:human genes:v:vasn|VASN]]|0.42|
|[[:human genes:i:ik|IK]]|0.419|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.417|
|[[:human genes:r:rpl8|RPL8]]|0.416|
|[[:human genes:c:chaf1a|CHAF1A]]|0.415|
|[[:human genes:s:slc4a1|SLC4A1]]|0.414|
|[[:human genes:t:tceb3c|TCEB3C]]|0.414|
|[[:human genes:r:ranbp2|RANBP2]]|0.413|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.411|
|[[:human genes:r:rrp15|RRP15]]|0.41|
|[[:human genes:c:cdh24|CDH24]]|0.41|
|[[:human genes:c:cbwd3|CBWD3]]|0.409|
|[[:human genes:n:narfl|NARFL]]|0.408|
|[[:human genes:s:slc7a6os|SLC7A6OS]]|0.406|
|[[:human genes:c:cdt1|CDT1]]|0.405|
|[[:human genes:s:smg1|SMG1]]|0.404|
|[[:human genes:n:nckap1l|NCKAP1L]]|0.404|
|[[:human genes:p:psmc2|PSMC2]]|0.401|
|[[:human genes:m:mul1|MUL1]]|0.401|
|[[:human genes:d:dock6|DOCK6]]|0.4|
|[[:human genes:c:ccna2|CCNA2]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1620
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.15 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MBTD1 Expression in NALM6 Cells: 6.15'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>