======= MCTS1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MCTS1
  * **<color #00a2e8>Official Name</color>**: MCTS1 re-initiation and release factor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=28985|28985]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9ULC4|Q9ULC4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MCTS1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MCTS1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300587|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Anti-oncogene that plays a role in cell cycle regulation; decreases cell doubling time and anchorage-dependent growth; shortens the duration of G1 transit time and G1/S transition. When constitutively expressed, increases CDK4 and CDK6 kinases activity and CCND1/cyclin D1 protein level, as well as G1 cyclin/CDK complex formation. Involved in translation initiation; promotes recruitment of aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. Plays a role as translation enhancer; recruits the density-regulated protein/DENR and binds to the cap complex of the 5'-terminus of mRNAs, subsequently altering the mRNA translation profile; up- regulates protein levels of BCL2L2, TFDP1, MRE11, CCND1 and E2F1, while mRNA levels remains constant. Hyperactivates DNA damage signaling pathway; increased gamma-irradiation-induced phosphorylation of histone H2AX, and induces damage foci formation. Increases the overall number of chromosomal abnormalities such as larger chromosomes formation and multiples chromosomal fusions when overexpressed in gamma-irradiated cells. May play a role in promoting lymphoid tumor development: lymphoid cell lines overexpressing MCTS1 exhibit increased growth rates and display increased protection against apoptosis. May contribute to the pathogenesis and progression of breast cancer via promotion of angiogenesis through the decline of inhibitory THBS1/thrombospondin-1, and inhibition of apoptosis. Involved in the process of proteasome degradation to down-regulate Tumor suppressor p53/TP53 in breast cancer cell; Positively regulates phosphorylation of MAPK1 and MAPK3. Involved in translation initiation; promotes aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. {ECO:0000269|PubMed:10440924, ECO:0000269|PubMed:11709712, ECO:0000269|PubMed:12637315, ECO:0000269|PubMed:15897892, ECO:0000269|PubMed:16322206, ECO:0000269|PubMed:16982740, ECO:0000269|PubMed:17016429, ECO:0000269|PubMed:17416211, ECO:0000269|PubMed:20713520, ECO:0000269|PubMed:9766643}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PUA|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|translation reinitiation|
|ribosome disassembly|
|IRES-dependent viral translational initiation|
|formation of translation preinitiation complex|
|viral translation|
|ribonucleoprotein complex disassembly|
|cytoplasmic translational initiation|
|cytosolic small ribosomal subunit|
|translation initiation factor activity|
|organelle disassembly|
|cytoplasmic translation|
|viral gene expression|
|translational initiation|
|ribonucleoprotein complex assembly|
|protein-containing complex disassembly|
|ribonucleoprotein complex subunit organization|
|translation|
|cellular component disassembly|
|peptide biosynthetic process|
|ribonucleoprotein complex biogenesis|
|amide biosynthetic process|
|peptide metabolic process|
|regulation of growth|
|viral process|
|cellular response to DNA damage stimulus|
|symbiotic process|
|cellular amide metabolic process|
|interspecies interaction between organisms|
|cellular protein-containing complex assembly|
|positive regulation of cell population proliferation|
|cell cycle|
|organonitrogen compound biosynthetic process|
|protein-containing complex assembly|
|regulation of cell population proliferation|
|cellular nitrogen compound biosynthetic process|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|-3.54|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|-2.9|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|-2.75|
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|-2.54|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|-2.51|
|[[:results:exp162|BI-D1870 2μM R04 exp162]]|-2.48|
|[[:results:exp401|SNS-032 25μM R07 exp401]]|-2.35|
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|-2.33|
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|-2.33|
|[[:results:exp187|proTAME 5μM R04 exp187]]|-2.23|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|-2.21|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|-2.08|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-2.03|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|-2.03|
|[[:results:exp210|LB-100 2μM R05 exp210]]|-1.94|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|-1.86|
|[[:results:exp285|GW501516 25μM R06 exp285]]|-1.82|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|-1.82|
|[[:results:exp344|Chlorpromazine 10μM R07 exp344]]|-1.81|
|[[:results:exp125|GSK461364A 0.005μM R03 exp125]]|-1.76|
|[[:results:exp218|A-395 10μM R05 exp218]]|-1.75|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|-1.75|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|-1.72|
|[[:results:exp415|Trichostatin-A 0.06μM R07 exp415]]|-1.71|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|-1.7|
|[[:results:exp495|IWR1 50μM R08 exp495]]|1.7|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|1.86|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|2.03|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|2.28|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:d:denr|DENR]]|0.657|
|[[:human genes:s:srpk1|SRPK1]]|0.442|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16369
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.09 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MCTS1 Expression in NALM6 Cells: 5.09'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>