======= MEAF6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MEAF6
  * **<color #00a2e8>Official Name</color>**: MYST/Esa1 associated factor 6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=64769|64769]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9HAF1|Q9HAF1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MEAF6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MEAF6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611001|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. {ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:18794358}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|NuA4|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|NuA3b histone acetyltransferase complex|
|NuA3a histone acetyltransferase complex|
|histone H3-K14 acetylation|
|histone H3-K23 acetylation|
|histone acetyltransferase activity (H3-K23 specific)|
|MOZ/MORF histone acetyltransferase complex|
|histone H4-K12 acetylation|
|histone H4-K8 acetylation|
|histone H4-K5 acetylation|
|histone H2A acetylation|
|NuA4 histone acetyltransferase complex|
|histone H4-K16 acetylation|
|histone H3 acetylation|
|histone H4 acetylation|
|kinetochore|
|condensed chromosome kinetochore|
|histone acetylation|
|internal peptidyl-lysine acetylation|
|peptidyl-lysine acetylation|
|internal protein amino acid acetylation|
|protein acetylation|
|regulation of signal transduction by p53 class mediator|
|protein acylation|
|peptidyl-lysine modification|
|histone modification|
|covalent chromatin modification|
|chromatin organization|
|nucleolus|
|peptidyl-amino acid modification|
|chromosome organization|
|regulation of intracellular signal transduction|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|1.73|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|1.76|
|[[:results:exp17|DABN 20μM R00 exp17]]|1.87|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|1.9|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|1.91|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|1.92|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|2.09|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|2.16|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|2.32|
|[[:results:exp211|AICAR 240μM R05 exp211]]|2.42|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|2.59|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|2.71|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|2.93|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|3.11|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|3.38|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|3.67|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|4.68|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|4.69|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hars|HARS]]|0.741|
|[[:human genes:r:rptor|RPTOR]]|0.63|
|[[:human genes:e:eif4e|EIF4E]]|0.598|
|[[:human genes:h:hspd1|HSPD1]]|0.593|
|[[:human genes:c:csnk2b|CSNK2B]]|0.585|
|[[:human genes:e:eny2|ENY2]]|0.584|
|[[:human genes:n:nxt1|NXT1]]|0.567|
|[[:human genes:m:mtor|MTOR]]|0.564|
|[[:human genes:p:polr3b|POLR3B]]|0.564|
|[[:human genes:r:rnmt|RNMT]]|0.561|
|[[:human genes:d:diablo|DIABLO]]|0.559|
|[[:human genes:w:wdr24|WDR24]]|0.556|
|[[:human genes:t:triap1|TRIAP1]]|0.541|
|[[:human genes:m:mllt1|MLLT1]]|0.532|
|[[:human genes:p:pelo|PELO]]|0.53|
|[[:human genes:r:rtcb|RTCB]]|0.529|
|[[:human genes:g:gmppb|GMPPB]]|0.529|
|[[:human genes:a:aars|AARS]]|0.529|
|[[:human genes:p:plaa|PLAA]]|0.528|
|[[:human genes:o:otud5|OTUD5]]|0.527|
|[[:human genes:p:pam16|PAM16]]|0.519|
|[[:human genes:m:mios|MIOS]]|0.518|
|[[:human genes:t:thoc6|THOC6]]|0.518|
|[[:human genes:c:casp9|CASP9]]|0.517|
|[[:human genes:g:gfpt1|GFPT1]]|0.516|
|[[:human genes:c:cct7|CCT7]]|0.511|
|[[:human genes:d:dad1|DAD1]]|0.51|
|[[:human genes:g:gabpa|GABPA]]|0.51|
|[[:human genes:t:tle4|TLE4]]|0.506|
|[[:human genes:a:apaf1|APAF1]]|0.504|
|[[:human genes:a:alg1|ALG1]]|0.503|
|[[:human genes:c:ccdc101|CCDC101]]|0.502|
|[[:human genes:s:seh1l|SEH1L]]|0.501|
|[[:human genes:d:dpagt1|DPAGT1]]|0.499|
|[[:human genes:h:hccs|HCCS]]|0.496|
|[[:human genes:t:tti2|TTI2]]|0.491|
|[[:human genes:n:nae1|NAE1]]|0.488|
|[[:human genes:w:wdr59|WDR59]]|0.487|
|[[:human genes:p:pmm2|PMM2]]|0.484|
|[[:human genes:n:nars|NARS]]|0.48|
|[[:human genes:u:ube2k|UBE2K]]|0.479|
|[[:human genes:m:max|MAX]]|0.476|
|[[:human genes:d:dohh|DOHH]]|0.472|
|[[:human genes:a:alg5|ALG5]]|0.471|
|[[:human genes:t:timm23b|TIMM23B]]|0.47|
|[[:human genes:t:thg1l|THG1L]]|0.468|
|[[:human genes:h:hhex|HHEX]]|0.467|
|[[:human genes:d:dhps|DHPS]]|0.466|
|[[:human genes:p:polr3h|POLR3H]]|0.465|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.464|
|[[:human genes:s:spcs2|SPCS2]]|0.463|
|[[:human genes:p:pisd|PISD]]|0.461|
|[[:human genes:z:znf608|ZNF608]]|0.46|
|[[:human genes:b:bap1|BAP1]]|0.456|
|[[:human genes:c:cars|CARS]]|0.456|
|[[:human genes:t:trnt1|TRNT1]]|0.455|
|[[:human genes:n:nupl2|NUPL2]]|0.453|
|[[:human genes:c:cycs|CYCS]]|0.453|
|[[:human genes:l:lamtor5|LAMTOR5]]|0.452|
|[[:human genes:m:mars|MARS]]|0.452|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.452|
|[[:human genes:u:uap1|UAP1]]|0.451|
|[[:human genes:a:atp5j|ATP5J]]|0.449|
|[[:human genes:b:brpf1|BRPF1]]|0.449|
|[[:human genes:s:smarcd1|SMARCD1]]|0.448|
|[[:human genes:i:ing5|ING5]]|0.448|
|[[:human genes:f:fbxo11|FBXO11]]|0.447|
|[[:human genes:a:alg14|ALG14]]|0.445|
|[[:human genes:t:tmem41b|TMEM41B]]|0.444|
|[[:human genes:r:rpn1|RPN1]]|0.444|
|[[:human genes:s:srp72|SRP72]]|0.443|
|[[:human genes:s:slc35b1|SLC35B1]]|0.443|
|[[:human genes:v:vmp1|VMP1]]|0.442|
|[[:human genes:f:faf2|FAF2]]|0.442|
|[[:human genes:e:elf2|ELF2]]|0.441|
|[[:human genes:u:ubqln1|UBQLN1]]|0.44|
|[[:human genes:e:eno1|ENO1]]|0.44|
|[[:human genes:n:nhlrc2|NHLRC2]]|0.439|
|[[:human genes:t:trmt5|TRMT5]]|0.438|
|[[:human genes:t:tgs1|TGS1]]|0.438|
|[[:human genes:c:crls1|CRLS1]]|0.437|
|[[:human genes:t:tbca|TBCA]]|0.437|
|[[:human genes:u:uba3|UBA3]]|0.437|
|[[:human genes:m:med23|MED23]]|0.436|
|[[:human genes:a:alg2|ALG2]]|0.436|
|[[:human genes:z:znf259|ZNF259]]|0.436|
|[[:human genes:u:ube2g1|UBE2G1]]|0.434|
|[[:human genes:t:tardbp|TARDBP]]|0.433|
|[[:human genes:b:bcl7a|BCL7A]]|0.432|
|[[:human genes:s:sec61g|SEC61G]]|0.432|
|[[:human genes:v:vdac2|VDAC2]]|0.43|
|[[:human genes:u:ube2l3|UBE2L3]]|0.429|
|[[:human genes:n:nsd1|NSD1]]|0.429|
|[[:human genes:p:pum1|PUM1]]|0.429|
|[[:human genes:v:vcpip1|VCPIP1]]|0.426|
|[[:human genes:h:hspa9|HSPA9]]|0.426|
|[[:human genes:l:lamtor4|LAMTOR4]]|0.425|
|[[:human genes:i:iars|IARS]]|0.425|
|[[:human genes:n:nup50|NUP50]]|0.424|
|[[:human genes:p:pax5|PAX5]]|0.424|
|[[:human genes:s:serf2|SERF2]]|0.423|
|[[:human genes:m:march5|MARCH5]]|0.421|
|[[:human genes:t:trim28|TRIM28]]|0.421|
|[[:human genes:v:vrk1|VRK1]]|0.42|
|[[:human genes:d:dhdds|DHDDS]]|0.42|
|[[:human genes:m:med16|MED16]]|0.418|
|[[:human genes:t:tsen34|TSEN34]]|0.418|
|[[:human genes:b:bak1|BAK1]]|0.416|
|[[:human genes:w:wars|WARS]]|0.414|
|[[:human genes:t:tp53|TP53]]|0.413|
|[[:human genes:o:oraov1|ORAOV1]]|0.413|
|[[:human genes:d:ddost|DDOST]]|0.412|
|[[:human genes:l:lsmd1|LSMD1]]|0.412|
|[[:human genes:m:mapk14|MAPK14]]|0.412|
|[[:human genes:a:alg13|ALG13]]|0.412|
|[[:human genes:p:ppp2r3c|PPP2R3C]]|0.412|
|[[:human genes:m:mfn1|MFN1]]|0.411|
|[[:human genes:t:tbp|TBP]]|0.411|
|[[:human genes:u:ubr5|UBR5]]|0.411|
|[[:human genes:d:dnajc3|DNAJC3]]|0.408|
|[[:human genes:y:yars|YARS]]|0.408|
|[[:human genes:t:taz|TAZ]]|0.408|
|[[:human genes:i:id3|ID3]]|0.407|
|[[:human genes:g:gnb1l|GNB1L]]|0.403|
|[[:human genes:s:suv420h1|SUV420H1]]|0.402|
|[[:human genes:b:bptf|BPTF]]|0.401|
|[[:human genes:c:cops8|COPS8]]|0.401|
|[[:human genes:a:abcb7|ABCB7]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 4/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|1/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|2/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2516
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.86 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MEAF6 Expression in NALM6 Cells: 5.86'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>