======= MED17 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MED17
  * **<color #00a2e8>Official Name</color>**: mediator complex subunit 17
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9440|9440]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NVC6|Q9NVC6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MED17&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MED17|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603810|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. {ECO:0000269|PubMed:16595664}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Med17|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|core mediator complex|
|vitamin D receptor binding|
|thyroid hormone receptor binding|
|mediator complex|
|nuclear receptor transcription coactivator activity|
|transcription coregulator activity|
|transcription initiation from RNA polymerase II promoter|
|transcription factor complex|
|DNA-templated transcription, initiation|
|transcription coactivator activity|
|transcription by RNA polymerase II|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|positive regulation of transcription by RNA polymerase II|
|organic cyclic compound biosynthetic process|
|positive regulation of transcription, DNA-templated|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|positive regulation of RNA metabolic process|
|macromolecule biosynthetic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|membrane|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-2.51|
|[[:results:exp135|MS023 7μM R03 exp135]]|-2.03|
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|-1.96|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|-1.77|
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|-1.72|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|1.73|
|[[:results:exp318|ABT-702 5μM R07 exp318]]|1.78|
|[[:results:exp463|Caffeine 2600μM R08 exp463]]|1.83|
|[[:results:exp58|UM131593 0.1μM R01 exp58]]|1.83|
|[[:results:exp316|Geldanamycin 0.015 to 0.025μM on day4 R07 exp316]]|2|
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|2.01|
|[[:results:exp27|Pimelic-diphenylamide-106 0.5μM R00 exp27]]|2.03|
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|2.09|
|[[:results:exp351|Dexamethasone 0.006μM R07 exp351]]|2.26|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|2.37|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:twistnb|TWISTNB]]|0.548|
|[[:human genes:p:prim1|PRIM1]]|0.531|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.53|
|[[:human genes:p:psmb2|PSMB2]]|0.524|
|[[:human genes:c:cbwd3|CBWD3]]|0.523|
|[[:human genes:s:supt6h|SUPT6H]]|0.52|
|[[:human genes:c:c14orf93|C14orf93]]|0.51|
|[[:human genes:r:rad21|RAD21]]|0.508|
|[[:human genes:c:cbwd5|CBWD5]]|0.498|
|[[:human genes:n:nbpf10|NBPF10]]|0.497|
|[[:human genes:p:pde4dip|PDE4DIP]]|0.496|
|[[:human genes:l:lrr1|LRR1]]|0.491|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.49|
|[[:human genes:r:rrm1|RRM1]]|0.49|
|[[:human genes:z:zfand5|ZFAND5]]|0.485|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.484|
|[[:human genes:a:akirin2|AKIRIN2]]|0.484|
|[[:human genes:r:rbbp5|RBBP5]]|0.483|
|[[:human genes:t:tyms|TYMS]]|0.48|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.48|
|[[:human genes:u:upf1|UPF1]]|0.479|
|[[:human genes:v:vasn|VASN]]|0.479|
|[[:human genes:n:npipb5|NPIPB5]]|0.479|
|[[:human genes:h:hap1|HAP1]]|0.479|
|[[:human genes:c:cbwd6|CBWD6]]|0.478|
|[[:human genes:d:dtl|DTL]]|0.476|
|[[:human genes:p:psmb4|PSMB4]]|0.476|
|[[:human genes:a:ankle2|ANKLE2]]|0.475|
|[[:human genes:m:myo1h|MYO1H]]|0.475|
|[[:human genes:h:hist2h3a|HIST2H3A]]|0.474|
|[[:human genes:h:hist2h3c|HIST2H3C]]|0.474|
|[[:human genes:t:traip|TRAIP]]|0.473|
|[[:human genes:p:psmd1|PSMD1]]|0.472|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.471|
|[[:human genes:n:nupl1|NUPL1]]|0.471|
|[[:human genes:e:elmod3|ELMOD3]]|0.468|
|[[:human genes:p:psmb1|PSMB1]]|0.468|
|[[:human genes:p:polr2j3|POLR2J3]]|0.466|
|[[:human genes:s:sec13|SEC13]]|0.464|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.463|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.463|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.463|
|[[:human genes:t:tceb3c|TCEB3C]]|0.463|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.463|
|[[:human genes:f:fbxo5|FBXO5]]|0.462|
|[[:human genes:r:rps2|RPS2]]|0.462|
|[[:human genes:m:med14|MED14]]|0.461|
|[[:human genes:c:chd4|CHD4]]|0.461|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.459|
|[[:human genes:e:exosc5|EXOSC5]]|0.458|
|[[:human genes:p:psma6|PSMA6]]|0.458|
|[[:human genes:c:cdc45|CDC45]]|0.457|
|[[:human genes:r:ranbp2|RANBP2]]|0.456|
|[[:human genes:t:ticrr|TICRR]]|0.455|
|[[:human genes:d:dnttip2|DNTTIP2]]|0.452|
|[[:human genes:p:psmd3|PSMD3]]|0.451|
|[[:human genes:g:gprin2|GPRIN2]]|0.451|
|[[:human genes:s:smg7|SMG7]]|0.449|
|[[:human genes:p:pcf11|PCF11]]|0.449|
|[[:human genes:p:pan2|PAN2]]|0.447|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.447|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.446|
|[[:human genes:o:ogfr|OGFR]]|0.446|
|[[:human genes:d:ddx23|DDX23]]|0.446|
|[[:human genes:r:rfxank|RFXANK]]|0.445|
|[[:human genes:o:orc1|ORC1]]|0.445|
|[[:human genes:k:kctd17|KCTD17]]|0.442|
|[[:human genes:c:cdc6|CDC6]]|0.44|
|[[:human genes:d:ddtl|DDTL]]|0.439|
|[[:human genes:g:gid4|GID4]]|0.438|
|[[:human genes:a:ahctf1|AHCTF1]]|0.438|
|[[:human genes:s:slc38a7|SLC38A7]]|0.437|
|[[:human genes:p:psmd14|PSMD14]]|0.436|
|[[:human genes:a:aqr|AQR]]|0.435|
|[[:human genes:n:nup160|NUP160]]|0.434|
|[[:human genes:m:mt1e|MT1E]]|0.434|
|[[:human genes:p:pbxip1|PBXIP1]]|0.433|
|[[:human genes:r:rnf121|RNF121]]|0.429|
|[[:human genes:p:pan3|PAN3]]|0.429|
|[[:human genes:p:psmc2|PSMC2]]|0.429|
|[[:human genes:r:ruvbl2|RUVBL2]]|0.429|
|[[:human genes:n:nfatc4|NFATC4]]|0.428|
|[[:human genes:c:cope|COPE]]|0.427|
|[[:human genes:s:supt5h|SUPT5H]]|0.427|
|[[:human genes:s:ssh2|SSH2]]|0.426|
|[[:human genes:s:sel1l|SEL1L]]|0.425|
|[[:human genes:l:lad1|LAD1]]|0.425|
|[[:human genes:m:mat2a|MAT2A]]|0.425|
|[[:human genes:c:chchd3|CHCHD3]]|0.424|
|[[:human genes:r:rrp15|RRP15]]|0.424|
|[[:human genes:s:snrpa1|SNRPA1]]|0.423|
|[[:human genes:z:znf655|ZNF655]]|0.423|
|[[:human genes:c:ciapin1|CIAPIN1]]|0.422|
|[[:human genes:m:med29|MED29]]|0.422|
|[[:human genes:t:top1mt|TOP1MT]]|0.42|
|[[:human genes:n:nup155|NUP155]]|0.42|
|[[:human genes:r:rps7|RPS7]]|0.42|
|[[:human genes:a:atp6v0b|ATP6V0B]]|0.418|
|[[:human genes:p:psma1|PSMA1]]|0.418|
|[[:human genes:z:znf106|ZNF106]]|0.418|
|[[:human genes:s:slc4a1|SLC4A1]]|0.418|
|[[:human genes:d:dync1i2|DYNC1I2]]|0.417|
|[[:human genes:r:ran|RAN]]|0.416|
|[[:human genes:p:psmc6|PSMC6]]|0.416|
|[[:human genes:p:psmd6|PSMD6]]|0.415|
|[[:human genes:p:polr1a|POLR1A]]|0.415|
|[[:human genes:n:nop16|NOP16]]|0.415|
|[[:human genes:s:smg1|SMG1]]|0.414|
|[[:human genes:p:pola1|POLA1]]|0.414|
|[[:human genes:f:fbxw9|FBXW9]]|0.414|
|[[:human genes:p:psmc1|PSMC1]]|0.411|
|[[:human genes:w:wdr75|WDR75]]|0.411|
|[[:human genes:h:hist1h2be|HIST1H2BE]]|0.41|
|[[:human genes:s:srrt|SRRT]]|0.409|
|[[:human genes:n:nup62|NUP62]]|0.409|
|[[:human genes:f:fam160a1|FAM160A1]]|0.408|
|[[:human genes:r:rpl35|RPL35]]|0.408|
|[[:human genes:r:rrp7a|RRP7A]]|0.407|
|[[:human genes:r:rpl14|RPL14]]|0.407|
|[[:human genes:h:hist2h2bf|HIST2H2BF]]|0.407|
|[[:human genes:c:ccna2|CCNA2]]|0.406|
|[[:human genes:e:ell|ELL]]|0.405|
|[[:human genes:c:cgb2|CGB2]]|0.405|
|[[:human genes:n:nup85|NUP85]]|0.405|
|[[:human genes:p:polr2d|POLR2D]]|0.404|
|[[:human genes:i:igfn1|IGFN1]]|0.404|
|[[:human genes:n:nup153|NUP153]]|0.404|
|[[:human genes:r:rrn3|RRN3]]|0.403|
|[[:human genes:u:utp20|UTP20]]|0.402|
|[[:human genes:s:scaf1|SCAF1]]|0.402|
|[[:human genes:d:disp2|DISP2]]|0.402|
|[[:human genes:c:copa|COPA]]|0.401|
|[[:human genes:p:psmd7|PSMD7]]|0.401|
|[[:human genes:p:pola2|POLA2]]|0.4|
|[[:human genes:x:xab2|XAB2]]|0.4|
|[[:human genes:p:psmc3|PSMC3]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 504/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|18/28|
|blood|21/28|
|bone|16/25|
|breast|25/33|
|central nervous system|43/56|
|cervix|3/4|
|colorectal|12/17|
|esophagus|11/13|
|fibroblast|1/1|
|gastric|5/15|
|kidney|15/21|
|liver|16/20|
|lung|45/75|
|lymphocyte|11/14|
|ovary|14/26|
|pancreas|16/24|
|peripheral nervous system|14/16|
|plasma cell|12/15|
|prostate|1/1|
|skin|17/24|
|soft tissue|5/7|
|thyroid|2/2|
|upper aerodigestive|12/22|
|urinary tract|15/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 701
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.11 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MED17 Expression in NALM6 Cells: 6.11'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>