======= MED25 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MED25
  * **<color #00a2e8>Official Name</color>**: mediator complex subunit 25
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=81857|81857]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q71SY5|Q71SY5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MED25&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MED25|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610197|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a component of the transcriptional coactivator complex termed the Mediator complex. This complex is required for transcription of most RNA polymerase II-dependent genes. The encoded protein plays a role in chromatin modification and in preinitiation complex assembly. Mutations in this gene are associated with Charcot-Marie-Tooth disease type 2B2. [provided by RefSeq, Apr 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Med25 VWA|
|Med25 SD1|
|Med25|
|Med25 NR-box|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of mediator complex assembly|
|positive regulation of mediator complex assembly|
|retinoic acid receptor binding|
|positive regulation of chromatin binding|
|retinoid X receptor binding|
|regulation of chromatin binding|
|nuclear transcription factor complex|
|negative regulation of fibroblast proliferation|
|mediator complex|
|positive regulation of cell cycle arrest|
|regulation of fibroblast proliferation|
|regulation of cell cycle arrest|
|transcription initiation from RNA polymerase II promoter|
|positive regulation of binding|
|DNA-templated transcription, initiation|
|positive regulation of protein complex assembly|
|positive regulation of cell cycle process|
|transcription factor binding|
|regulation of binding|
|positive regulation of cell cycle|
|regulation of protein complex assembly|
|transcription by RNA polymerase II|
|positive regulation of cellular component biogenesis|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|negative regulation of cell population proliferation|
|regulation of cell cycle process|
|negative regulation of transcription by RNA polymerase II|
|regulation of cellular component biogenesis|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|positive regulation of cellular component organization|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|organic cyclic compound biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|regulation of cell population proliferation|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|macromolecule biosynthetic process|
|positive regulation of molecular function|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|-2.64|
|[[:results:exp462|Cadmium 60μM R08 exp462]]|-2.43|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|-2.01|
|[[:results:exp11|CCCP 1μM R00 exp11]]|-1.94|
|[[:results:exp415|Trichostatin-A 0.06μM R07 exp415]]|-1.82|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|-1.81|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|1.71|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|2|
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|2.01|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|2.1|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|2.17|
|[[:results:exp382|Palbociclib 1μM R07 exp382]]|2.22|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:ccdc101|CCDC101]]|0.517|
|[[:human genes:m:mllt1|MLLT1]]|0.49|
|[[:human genes:d:dpagt1|DPAGT1]]|0.465|
|[[:human genes:t:tle4|TLE4]]|0.464|
|[[:human genes:t:thoc6|THOC6]]|0.461|
|[[:human genes:u:ube2l3|UBE2L3]]|0.461|
|[[:human genes:m:med16|MED16]]|0.455|
|[[:human genes:a:alg5|ALG5]]|0.45|
|[[:human genes:s:supt7l|SUPT7L]]|0.445|
|[[:human genes:o:otud5|OTUD5]]|0.438|
|[[:human genes:i:irf2bp2|IRF2BP2]]|0.437|
|[[:human genes:t:trim28|TRIM28]]|0.434|
|[[:human genes:n:nae1|NAE1]]|0.433|
|[[:human genes:g:gfpt1|GFPT1]]|0.431|
|[[:human genes:h:hars|HARS]]|0.423|
|[[:human genes:f:fh|FH]]|0.421|
|[[:human genes:d:dnajc3|DNAJC3]]|0.414|
|[[:human genes:t:taf5l|TAF5L]]|0.414|
|[[:human genes:a:atp5j|ATP5J]]|0.413|
|[[:human genes:l:lsm10|LSM10]]|0.411|
|[[:human genes:a:atxn10|ATXN10]]|0.41|
|[[:human genes:t:trmt5|TRMT5]]|0.409|
|[[:human genes:b:btaf1|BTAF1]]|0.408|
|[[:human genes:g:gnb1l|GNB1L]]|0.407|
|[[:human genes:i:id3|ID3]]|0.407|
|[[:human genes:u:ubr5|UBR5]]|0.407|
|[[:human genes:c:cbx3|CBX3]]|0.406|
|[[:human genes:m:med13l|MED13L]]|0.404|
|[[:human genes:t:taf6l|TAF6L]]|0.402|
|[[:human genes:t:tsen54|TSEN54]]|0.402|
|[[:human genes:f:fbxo11|FBXO11]]|0.401|
|[[:human genes:b:bap1|BAP1]]|0.401|
|[[:human genes:v:vmp1|VMP1]]|0.4|
|[[:human genes:d:dolk|DOLK]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 6/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|1/25|
|breast|0/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|1/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|2/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2698
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.05 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MED25 Expression in NALM6 Cells: 5.05'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>