======= METTL17 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: METTL17
  * **<color #00a2e8>Official Name</color>**: methyltransferase like 17
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=64745|64745]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H7H0|Q9H7H0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=METTL17&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20METTL17|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616091|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May be a component of the mitochondrial small ribosomal subunit. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Rsm22|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ribosome|
|methyltransferase activity|
|methylation|
|translation|
|peptide biosynthetic process|
|amide biosynthetic process|
|peptide metabolic process|
|cellular amide metabolic process|
|mitochondrion|
|organonitrogen compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp99|NFN1 0.4μM R03 exp99]]|-1.71|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|1.71|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|1.71|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|1.73|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|1.74|
|[[:results:exp532|TIC10 10μM R08 exp532]]|1.76|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|1.85|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|1.86|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|1.89|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|1.91|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|1.93|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|1.97|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|1.98|
|[[:results:exp360|Genistein 15μM R07 exp360]]|1.99|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|2.08|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|2.09|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|2.21|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|2.44|
|[[:results:exp82|Torin1 0.08μM R02 exp82]]|2.85|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:pet117|PET117]]|0.633|
|[[:human genes:p:pet112|PET112]]|0.623|
|[[:human genes:n:nars2|NARS2]]|0.608|
|[[:human genes:f:ftsj2|FTSJ2]]|0.6|
|[[:human genes:p:pars2|PARS2]]|0.599|
|[[:human genes:m:mrps27|MRPS27]]|0.586|
|[[:human genes:q:qrsl1|QRSL1]]|0.586|
|[[:human genes:p:polrmt|POLRMT]]|0.586|
|[[:human genes:n:ndufb11|NDUFB11]]|0.576|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.576|
|[[:human genes:c:chchd1|CHCHD1]]|0.575|
|[[:human genes:f:fastkd2|FASTKD2]]|0.574|
|[[:human genes:m:mrps6|MRPS6]]|0.573|
|[[:human genes:c:cox11|COX11]]|0.571|
|[[:human genes:l:lars2|LARS2]]|0.57|
|[[:human genes:n:ndufa2|NDUFA2]]|0.569|
|[[:human genes:a:aars2|AARS2]]|0.568|
|[[:human genes:c:coa3|COA3]]|0.567|
|[[:human genes:s:sco2|SCO2]]|0.567|
|[[:human genes:g:gfm2|GFM2]]|0.567|
|[[:human genes:m:mrpl47|MRPL47]]|0.566|
|[[:human genes:m:mrpl21|MRPL21]]|0.565|
|[[:human genes:m:mrps21|MRPS21]]|0.562|
|[[:human genes:s:selrc1|SELRC1]]|0.562|
|[[:human genes:d:ddx28|DDX28]]|0.562|
|[[:human genes:e:ears2|EARS2]]|0.561|
|[[:human genes:a:acad9|ACAD9]]|0.559|
|[[:human genes:y:yars2|YARS2]]|0.551|
|[[:human genes:m:mrpl13|MRPL13]]|0.55|
|[[:human genes:r:rbfa|RBFA]]|0.55|
|[[:human genes:m:mrps5|MRPS5]]|0.547|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.546|
|[[:human genes:n:ndufb9|NDUFB9]]|0.546|
|[[:human genes:m:mtif2|MTIF2]]|0.544|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.542|
|[[:human genes:t:tars2|TARS2]]|0.542|
|[[:human genes:m:mrps12|MRPS12]]|0.54|
|[[:human genes:m:mtg1|MTG1]]|0.539|
|[[:human genes:m:mrps26|MRPS26]]|0.539|
|[[:human genes:m:mrps34|MRPS34]]|0.534|
|[[:human genes:m:mrpl45|MRPL45]]|0.534|
|[[:human genes:r:rars2|RARS2]]|0.532|
|[[:human genes:r:rpusd3|RPUSD3]]|0.529|
|[[:human genes:n:ndufa11|NDUFA11]]|0.527|
|[[:human genes:g:gfm1|GFM1]]|0.526|
|[[:human genes:g:grsf1|GRSF1]]|0.524|
|[[:human genes:c:c12orf65|C12orf65]]|0.523|
|[[:human genes:m:mrpl17|MRPL17]]|0.523|
|[[:human genes:m:mto1|MTO1]]|0.522|
|[[:human genes:p:polg|POLG]]|0.521|
|[[:human genes:m:mrpl23|MRPL23]]|0.521|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.52|
|[[:human genes:n:nsun4|NSUN4]]|0.52|
|[[:human genes:n:ndufs2|NDUFS2]]|0.519|
|[[:human genes:n:ndufa3|NDUFA3]]|0.518|
|[[:human genes:c:coa6|COA6]]|0.517|
|[[:human genes:t:tfb1m|TFB1M]]|0.517|
|[[:human genes:d:dap3|DAP3]]|0.517|
|[[:human genes:m:mrpl3|MRPL3]]|0.516|
|[[:human genes:p:ptcd3|PTCD3]]|0.514|
|[[:human genes:n:nubpl|NUBPL]]|0.514|
|[[:human genes:w:wars2|WARS2]]|0.513|
|[[:human genes:r:rpusd4|RPUSD4]]|0.511|
|[[:human genes:m:mrps25|MRPS25]]|0.51|
|[[:human genes:m:mterfd2|MTERFD2]]|0.509|
|[[:human genes:m:mrpl53|MRPL53]]|0.508|
|[[:human genes:v:vars2|VARS2]]|0.507|
|[[:human genes:g:gtpbp6|GTPBP6]]|0.506|
|[[:human genes:m:mrps35|MRPS35]]|0.506|
|[[:human genes:h:hars2|HARS2]]|0.502|
|[[:human genes:p:polg2|POLG2]]|0.502|
|[[:human genes:m:mipep|MIPEP]]|0.496|
|[[:human genes:m:mrpl15|MRPL15]]|0.496|
|[[:human genes:n:ndufa1|NDUFA1]]|0.494|
|[[:human genes:m:mrps16|MRPS16]]|0.494|
|[[:human genes:f:fastkd5|FASTKD5]]|0.494|
|[[:human genes:m:mtg2|MTG2]]|0.49|
|[[:human genes:m:mrpl42|MRPL42]]|0.489|
|[[:human genes:m:mrpl4|MRPL4]]|0.488|
|[[:human genes:m:mrps24|MRPS24]]|0.488|
|[[:human genes:n:ndufa8|NDUFA8]]|0.487|
|[[:human genes:m:mrps23|MRPS23]]|0.483|
|[[:human genes:m:mterfd1|MTERFD1]]|0.482|
|[[:human genes:m:mars2|MARS2]]|0.482|
|[[:human genes:m:mrps10|MRPS10]]|0.481|
|[[:human genes:c:clpp|CLPP]]|0.48|
|[[:human genes:h:hmgxb3|HMGXB3]]|0.479|
|[[:human genes:n:ndufs5|NDUFS5]]|0.479|
|[[:human genes:d:dars2|DARS2]]|0.479|
|[[:human genes:m:malsu1|MALSU1]]|0.478|
|[[:human genes:w:wbscr16|WBSCR16]]|0.478|
|[[:human genes:f:fars2|FARS2]]|0.477|
|[[:human genes:b:bcs1l|BCS1L]]|0.475|
|[[:human genes:c:coq7|COQ7]]|0.475|
|[[:human genes:c:cox16|COX16]]|0.474|
|[[:human genes:t:tefm|TEFM]]|0.473|
|[[:human genes:m:mrp63|MRP63]]|0.472|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.471|
|[[:human genes:m:mrpl2|MRPL2]]|0.467|
|[[:human genes:t:timmdc1|TIMMDC1]]|0.467|
|[[:human genes:e:eral1|ERAL1]]|0.466|
|[[:human genes:c:cox15|COX15]]|0.466|
|[[:human genes:g:gatc|GATC]]|0.466|
|[[:human genes:c:coq2|COQ2]]|0.466|
|[[:human genes:n:ndufc2|NDUFC2]]|0.465|
|[[:human genes:t:trub2|TRUB2]]|0.465|
|[[:human genes:r:rnmtl1|RNMTL1]]|0.463|
|[[:human genes:m:mrpl51|MRPL51]]|0.463|
|[[:human genes:m:mrpl12|MRPL12]]|0.462|
|[[:human genes:p:pnpt1|PNPT1]]|0.462|
|[[:human genes:c:cars2|CARS2]]|0.46|
|[[:human genes:n:ndufs7|NDUFS7]]|0.459|
|[[:human genes:m:mcat|MCAT]]|0.459|
|[[:human genes:m:mrpl1|MRPL1]]|0.459|
|[[:human genes:n:ndufa10|NDUFA10]]|0.457|
|[[:human genes:n:ndufb7|NDUFB7]]|0.456|
|[[:human genes:g:gtpbp8|GTPBP8]]|0.456|
|[[:human genes:m:mrps14|MRPS14]]|0.456|
|[[:human genes:n:ndufb6|NDUFB6]]|0.455|
|[[:human genes:m:mrpl43|MRPL43]]|0.454|
|[[:human genes:m:mrpl49|MRPL49]]|0.453|
|[[:human genes:x:xpnpep3|XPNPEP3]]|0.452|
|[[:human genes:m:mrps11|MRPS11]]|0.45|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.45|
|[[:human genes:m:mrpl18|MRPL18]]|0.449|
|[[:human genes:s:slc31a1|SLC31A1]]|0.449|
|[[:human genes:n:ndufb4|NDUFB4]]|0.448|
|[[:human genes:m:mrpl44|MRPL44]]|0.448|
|[[:human genes:m:mrps7|MRPS7]]|0.447|
|[[:human genes:i:iba57|IBA57]]|0.447|
|[[:human genes:n:ndufc1|NDUFC1]]|0.446|
|[[:human genes:s:ssbp1|SSBP1]]|0.445|
|[[:human genes:p:prepl|PREPL]]|0.444|
|[[:human genes:n:noa1|NOA1]]|0.444|
|[[:human genes:n:ndufaf6|NDUFAF6]]|0.444|
|[[:human genes:i:ict1|ICT1]]|0.442|
|[[:human genes:s:sco1|SCO1]]|0.442|
|[[:human genes:m:mtrf1|MTRF1]]|0.44|
|[[:human genes:s:slc25a3|SLC25A3]]|0.438|
|[[:human genes:c:cox17|COX17]]|0.437|
|[[:human genes:m:mrps18a|MRPS18A]]|0.437|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.436|
|[[:human genes:p:pitrm1|PITRM1]]|0.436|
|[[:human genes:n:ndufb10|NDUFB10]]|0.435|
|[[:human genes:n:ndufaf5|NDUFAF5]]|0.433|
|[[:human genes:a:atp5sl|ATP5SL]]|0.432|
|[[:human genes:n:ndufb2|NDUFB2]]|0.431|
|[[:human genes:f:foxred1|FOXRED1]]|0.431|
|[[:human genes:n:ndufs8|NDUFS8]]|0.43|
|[[:human genes:m:mrpl37|MRPL37]]|0.429|
|[[:human genes:e:ecsit|ECSIT]]|0.427|
|[[:human genes:m:mrpl52|MRPL52]]|0.426|
|[[:human genes:m:mrps33|MRPS33]]|0.426|
|[[:human genes:a:aifm1|AIFM1]]|0.425|
|[[:human genes:t:tufm|TUFM]]|0.425|
|[[:human genes:l:lrpprc|LRPPRC]]|0.423|
|[[:human genes:n:ndufv1|NDUFV1]]|0.423|
|[[:human genes:c:cox20|COX20]]|0.421|
|[[:human genes:m:mrpl22|MRPL22]]|0.421|
|[[:human genes:t:trit1|TRIT1]]|0.419|
|[[:human genes:n:ndufaf1|NDUFAF1]]|0.419|
|[[:human genes:m:mtpap|MTPAP]]|0.418|
|[[:human genes:t:tomm20|TOMM20]]|0.418|
|[[:human genes:p:pdss2|PDSS2]]|0.416|
|[[:human genes:p:pde12|PDE12]]|0.415|
|[[:human genes:m:mrps18b|MRPS18B]]|0.415|
|[[:human genes:s:slc25a51|SLC25A51]]|0.411|
|[[:human genes:c:cox19|COX19]]|0.41|
|[[:human genes:y:ybey|YBEY]]|0.409|
|[[:human genes:c:cox6b1|COX6B1]]|0.408|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.408|
|[[:human genes:n:ndufv2|NDUFV2]]|0.408|
|[[:human genes:c:c1qbp|C1QBP]]|0.407|
|[[:human genes:m:mrps28|MRPS28]]|0.404|
|[[:human genes:m:mrpl20|MRPL20]]|0.404|
|[[:human genes:n:ndufa13|NDUFA13]]|0.403|
|[[:human genes:m:mrpl55|MRPL55]]|0.402|
|[[:human genes:m:mcur1|MCUR1]]|0.401|
|[[:human genes:m:mrps17|MRPS17]]|0.4|
|[[:human genes:m:mrpl14|MRPL14]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 37/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|2/28|
|bone|3/26|
|breast|2/33|
|central nervous system|2/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|1/21|
|liver|1/20|
|lung|5/75|
|lymphocyte|2/16|
|ovary|0/26|
|pancreas|1/24|
|peripheral nervous system|0/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 826
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.82 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='METTL17 Expression in NALM6 Cells: 6.82'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>