======= MFGE8 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MFGE8
  * **<color #00a2e8>Official Name</color>**: milk fat globule EGF and factor V/VIII domain containing
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4240|4240]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q08431|Q08431]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MFGE8&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MFGE8|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602281|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing. Promotes VEGF-dependent neovascularization (By similarity). Contributes to phagocytic removal of apoptotic cells in many tissues. Specific ligand for the alpha-v/beta-3 and alpha-v/beta-5 receptors. Also binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner. Zona pellucida-binding protein which may play a role in gamete interaction. Binds specifically to rotavirus and inhibits its replication. {ECO:0000250, ECO:0000269|PubMed:19204935}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|F5 F8 type C|
|EGF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|phosphatidylethanolamine binding|
|extrinsic component of plasma membrane|
|apoptotic cell clearance|
|extracellular vesicle|
|phosphatidylserine binding|
|positive regulation of phagocytosis|
|regulation of phagocytosis|
|phagocytosis, recognition|
|phagocytosis, engulfment|
|integrin binding|
|extracellular matrix structural constituent|
|plasma membrane invagination|
|single fertilization|
|membrane invagination|
|fertilization|
|cell recognition|
|endoplasmic reticulum lumen|
|angiogenesis|
|phagocytosis|
|post-translational protein modification|
|collagen-containing extracellular matrix|
|external side of plasma membrane|
|blood vessel morphogenesis|
|blood vessel development|
|vasculature development|
|cardiovascular system development|
|regulation of vesicle-mediated transport|
|endocytosis|
|tube morphogenesis|
|import into cell|
|sexual reproduction|
|tube development|
|membrane organization|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|cell adhesion|
|biological adhesion|
|positive regulation of transport|
|multi-organism reproductive process|
|reproductive process|
|reproduction|
|extracellular space|
|regulation of transport|
|extracellular region|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp298|Sucrose 20000μM R06 exp298]]|2.13|
|[[:results:exp292|Menadione 5μM R06 exp292]]|2.57|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3114
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.7 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MFGE8 Expression in NALM6 Cells: 5.7'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>