======= MFNG =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MFNG
  * **<color #00a2e8>Official Name</color>**: MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4242|4242]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O00587|O00587]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MFNG&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MFNG|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602577|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Glycosyltransferase that initiates the elongation of O- linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules (PubMed:10935626). Modulates NOTCH1 activity by modifying O-fucose residues at specific EGF-like domains resulting in inhibition of NOTCH1 activation by JAG1 and enhancement of NOTCH1 activation by DLL1 via an increase in its binding to DLL1 (By similarity). {ECO:0000250|UniProtKB:O09008, ECO:0000269|PubMed:10935626}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Fringe|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity|
|protein O-linked fucosylation|
|marginal zone B cell differentiation|
|mature B cell differentiation involved in immune response|
|fucosylation|
|acetylglucosaminyltransferase activity|
|mature B cell differentiation|
|blastocyst formation|
|B cell activation involved in immune response|
|positive regulation of Notch signaling pathway|
|integral component of Golgi membrane|
|positive regulation of protein binding|
|blastocyst development|
|regulation of Notch signaling pathway|
|B cell differentiation|
|protein O-linked glycosylation|
|lymphocyte activation involved in immune response|
|B cell activation|
|positive regulation of binding|
|regulation of protein binding|
|lymphocyte differentiation|
|protein glycosylation|
|macromolecule glycosylation|
|glycosylation|
|glycoprotein biosynthetic process|
|leukocyte differentiation|
|in utero embryonic development|
|regulation of binding|
|lymphocyte activation|
|glycoprotein metabolic process|
|pattern specification process|
|hemopoiesis|
|hematopoietic or lymphoid organ development|
|carbohydrate derivative biosynthetic process|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|chordate embryonic development|
|immune system development|
|embryo development ending in birth or egg hatching|
|anatomical structure formation involved in morphogenesis|
|leukocyte activation|
|embryo development|
|carbohydrate derivative metabolic process|
|cell activation|
|immune effector process|
|organonitrogen compound biosynthetic process|
|extracellular space|
|positive regulation of signal transduction|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|positive regulation of molecular function|
|positive regulation of cell communication|
|positive regulation of signaling|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13199
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.49 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MFNG Expression in NALM6 Cells: 6.49'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>