======= MIEF1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MIEF1
  * **<color #00a2e8>Official Name</color>**: mitochondrial elongation factor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=54471|54471]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/"L0R8F8|Q9NQG6"|"L0R8F8|Q9NQG6"]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MIEF1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MIEF1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615497|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Mab-21|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of mitochondrial fission|
|mitochondrial fusion|
|mitochondrial fission|
|regulation of mitochondrial fission|
|positive regulation of protein targeting to membrane|
|regulation of protein targeting to membrane|
|ADP binding|
|GDP binding|
|regulation of protein targeting|
|organelle fusion|
|peroxisome|
|positive regulation of mitochondrion organization|
|positive regulation of protein localization to membrane|
|positive regulation of intracellular protein transport|
|mitochondrial outer membrane|
|regulation of mitochondrion organization|
|regulation of protein localization to membrane|
|positive regulation of intracellular transport|
|regulation of intracellular protein transport|
|organelle fission|
|positive regulation of cellular protein localization|
|regulation of intracellular transport|
|positive regulation of protein transport|
|mitochondrion organization|
|positive regulation of establishment of protein localization|
|regulation of cellular protein localization|
|positive regulation of organelle organization|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of cellular localization|
|positive regulation of transport|
|regulation of protein localization|
|regulation of anatomical structure morphogenesis|
|identical protein binding|
|positive regulation of cellular component organization|
|mitochondrion|
|regulation of organelle organization|
|positive regulation of developmental process|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|-2.11|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|-1.81|
|[[:results:exp17|DABN 20μM R00 exp17]]|-1.75|
|[[:results:exp238|Parthenolide 2.5μM R05 exp238]]|-1.74|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|-1.73|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|1.77|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:prim1|PRIM1]]|0.537|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10869
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.92 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MIEF1 Expression in NALM6 Cells: 6.92'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>