======= MIXL1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MIXL1
  * **<color #00a2e8>Official Name</color>**: Mix paired-like homeobox
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=83881|83881]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H2W2|Q9H2W2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MIXL1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MIXL1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609852|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Transcription factor that play a central role in proper axial mesendoderm morphogenesis and endoderm formation. Required for efficient differentiation of cells from the primitive streak stage to blood, by acting early in the recruitment and/or expansion of mesodermal progenitors to the hemangioblastic and hematopoietic lineages. Also involved in the morphogenesis of the heart and the gut during embryogenesis. Acts as a negative regulator of brachyury expression (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Homeobox|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of mesoderm development|
|negative regulation of hematopoietic progenitor cell differentiation|
|cell migration involved in gastrulation|
|regulation of mesoderm development|
|proximal promoter sequence-specific DNA binding|
|RNA polymerase II repressing transcription factor binding|
|endodermal cell differentiation|
|endoderm formation|
|RNA polymerase II transcription factor binding|
|endoderm development|
|regulation of hematopoietic progenitor cell differentiation|
|hematopoietic progenitor cell differentiation|
|RNA polymerase II distal enhancer sequence-specific DNA binding|
|formation of primary germ layer|
|digestive tract development|
|negative regulation of hemopoiesis|
|digestive system development|
|gastrulation|
|ameboidal-type cell migration|
|nuclear chromatin|
|negative regulation of immune system process|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|regulation of hemopoiesis|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|heart development|
|hemopoiesis|
|embryonic morphogenesis|
|hematopoietic or lymphoid organ development|
|immune system development|
|negative regulation of cell differentiation|
|tube development|
|circulatory system development|
|protein homodimerization activity|
|anatomical structure formation involved in morphogenesis|
|negative regulation of developmental process|
|cell migration|
|embryo development|
|cell motility|
|localization of cell|
|negative regulation of multicellular organismal process|
|positive regulation of transcription by RNA polymerase II|
|locomotion|
|positive regulation of developmental process|
|positive regulation of transcription, DNA-templated|
|movement of cell or subcellular component|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|regulation of immune system process|
|positive regulation of RNA metabolic process|
|tissue development|
|regulation of cell differentiation|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14549
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.63 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MIXL1 Expression in NALM6 Cells: 0.63'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>