======= MKI67IP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NIFK
  * **<color #00a2e8>Official Name</color>**: nucleolar protein interacting with the FHA domain of MKI67
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=84365|84365]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BYG3|Q9BYG3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MKI67IP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MKI67IP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611970|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RRM 1|
|hNIFK binding|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|rRNA transcription|
|condensed nuclear chromosome|
|ncRNA transcription|
|rRNA metabolic process|
|ncRNA metabolic process|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|nucleolus|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|RNA binding|
|protein-containing complex assembly|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp237|NN-Diethyl-meta-toluamide 100μM R05 exp237]]|1.7|
|[[:results:exp15|Cycloheximide 0.2μM R00 exp15]]|1.74|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|1.89|
|[[:results:exp10|CCCP 0.1μM R00 exp10]]|1.96|
|[[:results:exp41|BI-2536 0.001μM R01 exp41]]|2.15|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rpl6|RPL6]]|0.491|
|[[:human genes:z:znf830|ZNF830]]|0.463|
|[[:human genes:p:polr1a|POLR1A]]|0.455|
|[[:human genes:c:chd4|CHD4]]|0.446|
|[[:human genes:c:col2a1|COL2A1]]|0.442|
|[[:human genes:n:nol12|NOL12]]|0.441|
|[[:human genes:r:rpl34|RPL34]]|0.441|
|[[:human genes:r:rpl35|RPL35]]|0.44|
|[[:human genes:t:twistnb|TWISTNB]]|0.433|
|[[:human genes:h:hap1|HAP1]]|0.432|
|[[:human genes:p:psmb3|PSMB3]]|0.431|
|[[:human genes:p:psmb4|PSMB4]]|0.424|
|[[:human genes:z:zfand5|ZFAND5]]|0.423|
|[[:human genes:s:slc4a1|SLC4A1]]|0.421|
|[[:human genes:r:rps7|RPS7]]|0.421|
|[[:human genes:r:rrp15|RRP15]]|0.419|
|[[:human genes:p:psma6|PSMA6]]|0.419|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.418|
|[[:human genes:r:rps12|RPS12]]|0.418|
|[[:human genes:c:cactin|CACTIN]]|0.416|
|[[:human genes:k:kctd17|KCTD17]]|0.407|
|[[:human genes:t:ticrr|TICRR]]|0.406|
|[[:human genes:z:znf655|ZNF655]]|0.406|
|[[:human genes:n:nol10|NOL10]]|0.404|
|[[:human genes:c:cdc73|CDC73]]|0.403|
|[[:human genes:c:cdh24|CDH24]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 714/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|23/26|
|breast|33/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|16/17|
|esophagus|12/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|19/20|
|lung|72/75|
|lymphocyte|15/16|
|ovary|24/26|
|pancreas|24/24|
|peripheral nervous system|15/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|8/9|
|thyroid|2/2|
|upper aerodigestive|21/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1502
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.17 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MKI67IP Expression in NALM6 Cells: 6.17'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>