======= MKLN1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MKLN1
  * **<color #00a2e8>Official Name</color>**: muskelin 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4289|4289]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UL63|Q9UL63]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MKLN1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MKLN1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605623|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Acts as a mediator of cell spreading and cytoskeletal responses to the extracellular matrix component THBS1. {ECO:0000250|UniProtKB:O89050}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|F5 F8 type C|
|Muskelin N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of receptor internalization|
|actin cytoskeleton reorganization|
|ruffle|
|regulation of receptor-mediated endocytosis|
|ubiquitin ligase complex|
|cell-matrix adhesion|
|cell cortex|
|regulation of cell shape|
|cell-substrate adhesion|
|regulation of endocytosis|
|synapse|
|regulation of cell morphogenesis|
|actin cytoskeleton organization|
|cell junction|
|regulation of vesicle-mediated transport|
|actin filament-based process|
|protein homodimerization activity|
|cell adhesion|
|biological adhesion|
|regulation of anatomical structure morphogenesis|
|cytoskeleton organization|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|-3.54|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|-2.39|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|-2.16|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|-2.13|
|[[:results:exp81|Selumetinib 20μM R02 exp81]]|-2.09|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|-1.97|
|[[:results:exp82|Torin1 0.08μM R02 exp82]]|-1.89|
|[[:results:exp463|Caffeine 2600μM R08 exp463]]|-1.85|
|[[:results:exp72|LB-100 4.1μM R02 exp72]]|-1.85|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-1.81|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|-1.81|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|-1.71|
|[[:results:exp15|Cycloheximide 0.2μM R00 exp15]]|1.75|
|[[:results:exp537|WNT3A 44ng/ml R08 exp537]]|1.76|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|1.8|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|2.43|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|3.04|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5385
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.45 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MKLN1 Expression in NALM6 Cells: 6.45'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>