======= MLLT10 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MLLT10
  * **<color #00a2e8>Official Name</color>**: MLLT10 histone lysine methyltransferase DOT1L cofactor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8028|8028]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P55197|P55197]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MLLT10&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MLLT10|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602409|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a transcription factor and has been identified as a partner gene involved in several chromosomal rearrangements resulting in various leukemias. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Probably involved in transcriptional regulation. In vitro or as fusion protein with KMT2A/MLL1 has transactivation activity. Binds to cruciform DNA. {ECO:0000269|PubMed:17868029}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PHD|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|nucleosome binding|
|histone binding|
|chromatin binding|
|protein-containing complex|
|DNA-binding transcription factor activity|
|positive regulation of transcription by RNA polymerase II|
|DNA binding|
|positive regulation of transcription, DNA-templated|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of RNA metabolic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|-2.05|
|[[:results:exp72|LB-100 4.1μM R02 exp72]]|-1.81|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|1.81|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|1.86|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|1.92|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|2.16|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|2.41|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:d:dot1l|DOT1L]]|0.521|
|[[:human genes:m:med13l|MED13L]]|0.416|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10494
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.05 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MLLT10 Expression in NALM6 Cells: 6.05'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>