======= MLLT4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: AFDN
  * **<color #00a2e8>Official Name</color>**: afadin, adherens junction formation factor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4301|4301]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P55196|P55196]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MLLT4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MLLT4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/159559|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a multi-domain protein involved in signaling and organization of cell junctions during embryogenesis. It has also been identified as the fusion partner of acute lymphoblastic leukemia (ALL-1) gene, involved in acute myeloid leukemias with t(6;11)(q27;q23) translocation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, however, not all have been fully characterized.[provided by RefSeq, May 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DIL|
|FHA|
|RA|
|PDZ|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|tight junction|
|positive regulation of cell-cell adhesion mediated by cadherin|
|pore complex|
|Ras GTPase binding|
|establishment of endothelial intestinal barrier|
|regulation of cell-cell adhesion mediated by cadherin|
|pore complex assembly|
|cell-cell contact zone|
|cell-cell adhesion mediated by cadherin|
|establishment of endothelial barrier|
|bicellular tight junction assembly|
|tight junction assembly|
|tight junction organization|
|apical junction assembly|
|endothelial cell development|
|establishment of protein localization to plasma membrane|
|cell adhesion molecule binding|
|endothelial cell differentiation|
|adherens junction organization|
|endothelium development|
|cell-cell adherens junction|
|cell-cell junction assembly|
|cell-cell junction organization|
|cell junction assembly|
|cell-cell junction|
|protein localization to plasma membrane|
|protein C-terminus binding|
|epithelial cell development|
|actin filament binding|
|cell junction organization|
|protein localization to cell periphery|
|positive regulation of cell-cell adhesion|
|negative regulation of cell migration|
|establishment of protein localization to membrane|
|negative regulation of cell motility|
|negative regulation of cellular component movement|
|cadherin binding|
|negative regulation of locomotion|
|regulation of cell-cell adhesion|
|nuclear speck|
|positive regulation of cell adhesion|
|positive regulation of GTPase activity|
|protein localization to membrane|
|regulation of GTPase activity|
|cell-cell adhesion|
|cell junction|
|epithelial cell differentiation|
|regulation of cell adhesion|
|positive regulation of hydrolase activity|
|regulation of cell migration|
|regulation of cell motility|
|cell adhesion|
|biological adhesion|
|regulation of locomotion|
|regulation of cellular component movement|
|regulation of protein localization|
|epithelium development|
|cell-cell signaling|
|regulation of hydrolase activity|
|positive regulation of catalytic activity|
|protein-containing complex assembly|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|cell development|
|tissue development|
|positive regulation of molecular function|
|protein-containing complex subunit organization|
|positive regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|-1.85|
|[[:results:exp223|Cabazitaxel 0.001μM R05 exp223]]|-1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 3/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|1/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7478
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.55 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MLLT4 Expression in NALM6 Cells: 6.55'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>