======= MMP2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MMP2
  * **<color #00a2e8>Official Name</color>**: matrix metallopeptidase 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4313|4313]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P08253|P08253]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MMP2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MMP2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/120360|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is a member of the matrix metalloproteinase (MMP) gene family, that are zinc-dependent enzymes capable of cleaving components of the extracellular matrix and molecules involved in signal transduction. The protein encoded by this gene is a gelatinase A, type IV collagenase, that contains three fibronectin type II repeats in its catalytic site that allow binding of denatured type IV and V collagen and elastin. Unlike most MMP family members, activation of this protein can occur on the cell membrane. This enzyme can be activated extracellularly by proteases, or, intracellulary by its S-glutathiolation with no requirement for proteolytical removal of the pro-domain. This protein is thought to be involved in multiple pathways including roles in the nervous system, endometrial menstrual breakdown, regulation of vascularization, and metastasis. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. Involved in the formation of the fibrovascular tissues in association with MMP14. Isoform 2: Mediates the proteolysis of CHUK/IKKA and initiates a primary innate immune response by inducing mitochondrial-nuclear stress signaling with activation of the pro- inflammatory NF-kappaB, NFAT and IRF transcriptional pathways.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PG binding 1|
|Hemopexin|
|fn2|
|Peptidase M10|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|direct ossification|
|intramembranous ossification|
|bone trabecula formation|
|blood vessel maturation|
|bone trabecula morphogenesis|
|trabecula formation|
|face morphogenesis|
|positive regulation of vascular smooth muscle cell proliferation|
|embryo implantation|
|head morphogenesis|
|endodermal cell differentiation|
|collagen catabolic process|
|trabecula morphogenesis|
|body morphogenesis|
|endoderm formation|
|face development|
|response to amyloid-beta|
|sarcomere|
|regulation of vascular smooth muscle cell proliferation|
|metallopeptidase activity|
|collagen metabolic process|
|extracellular matrix disassembly|
|cellular response to amino acid stimulus|
|endoderm development|
|positive regulation of smooth muscle cell proliferation|
|ephrin receptor signaling pathway|
|tissue remodeling|
|metalloendopeptidase activity|
|formation of primary germ layer|
|response to amino acid|
|cellular response to reactive oxygen species|
|regulation of smooth muscle cell proliferation|
|anatomical structure maturation|
|gastrulation|
|serine-type endopeptidase activity|
|female pregnancy|
|response to reactive oxygen species|
|cellular response to acid chemical|
|multi-multicellular organism process|
|skeletal system morphogenesis|
|cellular response to oxidative stress|
|developmental maturation|
|ossification|
|angiogenesis|
|extracellular matrix organization|
|response to hypoxia|
|response to acid chemical|
|response to decreased oxygen levels|
|collagen-containing extracellular matrix|
|response to oxygen levels|
|extracellular structure organization|
|response to oxidative stress|
|cellular component disassembly|
|blood vessel morphogenesis|
|response to peptide|
|blood vessel development|
|skeletal system development|
|vasculature development|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|cardiovascular system development|
|embryonic morphogenesis|
|cellular response to organonitrogen compound|
|tube morphogenesis|
|cellular response to nitrogen compound|
|cytokine-mediated signaling pathway|
|enzyme linked receptor protein signaling pathway|
|head development|
|zinc ion binding|
|tube development|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|positive regulation of cell population proliferation|
|animal organ morphogenesis|
|embryo development|
|multi-organism reproductive process|
|response to organonitrogen compound|
|cellular response to cytokine stimulus|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|response to cytokine|
|response to abiotic stimulus|
|cellular response to endogenous stimulus|
|mitochondrion|
|proteolysis|
|reproductive process|
|reproduction|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|extracellular space|
|regulation of cell population proliferation|
|cellular response to stress|
|tissue development|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12252
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -3.59 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MMP2 Expression in NALM6 Cells: -3.59'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>