======= MMP3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MMP3
  * **<color #00a2e8>Official Name</color>**: matrix metallopeptidase 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4314|4314]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P08254|P08254]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MMP3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MMP3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/185250|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Hemopexin|
|PG binding 1|
|Peptidase M10|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of hydrogen peroxide metabolic process|
|negative regulation of cofactor metabolic process|
|positive regulation of oxidative stress-induced cell death|
|cellular response to nitric oxide|
|positive regulation of cellular response to oxidative stress|
|response to nitric oxide|
|positive regulation of response to oxidative stress|
|cellular response to reactive nitrogen species|
|regulation of hydrogen peroxide metabolic process|
|positive regulation of protein oligomerization|
|regulation of neuroinflammatory response|
|regulation of cofactor metabolic process|
|collagen catabolic process|
|regulation of protein oligomerization|
|response to amyloid-beta|
|response to bronchodilator|
|negative regulation of reactive oxygen species metabolic process|
|regulation of oxidative stress-induced cell death|
|metallopeptidase activity|
|collagen metabolic process|
|extracellular matrix disassembly|
|regulation of cellular response to oxidative stress|
|endopeptidase activity|
|regulation of response to oxidative stress|
|metalloendopeptidase activity|
|cellular response to reactive oxygen species|
|serine-type endopeptidase activity|
|regulation of reactive oxygen species metabolic process|
|response to reactive oxygen species|
|cellular response to inorganic substance|
|extracellular matrix|
|cellular response to oxidative stress|
|positive regulation of protein complex assembly|
|regulation of inflammatory response|
|extracellular matrix organization|
|extracellular structure organization|
|response to oxidative stress|
|cellular component disassembly|
|cellular response to drug|
|regulation of protein complex assembly|
|response to peptide|
|positive regulation of cellular component biogenesis|
|response to inorganic substance|
|cellular response to nitrogen compound|
|cytokine-mediated signaling pathway|
|positive regulation of cell death|
|regulation of cellular response to stress|
|regulation of defense response|
|zinc ion binding|
|regulation of cellular component biogenesis|
|response to organonitrogen compound|
|cellular response to cytokine stimulus|
|response to drug|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|regulation of response to external stimulus|
|response to cytokine|
|positive regulation of cellular component organization|
|proteolysis|
|regulation of response to stress|
|response to oxygen-containing compound|
|extracellular space|
|regulation of cell death|
|cellular response to stress|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|-2.16|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|-1.76|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.482|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6430
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MMP3 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>