======= MRPL18 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MRPL18
  * **<color #00a2e8>Official Name</color>**: mitochondrial ribosomal protein L18
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=29074|29074]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H0U6|Q9H0U6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MRPL18&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MRPL18|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611831|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ribosomal L18p|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|rRNA import into mitochondrion|
|RNA import into mitochondrion|
|rRNA transport|
|5S rRNA binding|
|mitochondrial ribosome|
|mitochondrial large ribosomal subunit|
|mitochondrial translational elongation|
|mitochondrial translational termination|
|mitochondrial transmembrane transport|
|translational termination|
|mitochondrial translation|
|translational elongation|
|cellular protein complex disassembly|
|mitochondrial gene expression|
|structural constituent of ribosome|
|RNA transport|
|nucleic acid transport|
|establishment of RNA localization|
|mitochondrial transport|
|RNA localization|
|nucleobase-containing compound transport|
|protein-containing complex disassembly|
|translation|
|mitochondrial inner membrane|
|cellular component disassembly|
|peptide biosynthetic process|
|amide biosynthetic process|
|peptide metabolic process|
|cellular amide metabolic process|
|mitochondrion|
|transmembrane transport|
|organonitrogen compound biosynthetic process|
|extracellular space|
|cellular nitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|1.74|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|1.77|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|1.82|
|[[:results:exp532|TIC10 10μM R08 exp532]]|1.86|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|1.87|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|1.88|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|1.88|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|1.93|
|[[:results:exp134|MS023 2μM R03 exp134]]|1.94|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|2.22|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|2.36|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|2.37|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:mrpl23|MRPL23]]|0.61|
|[[:human genes:m:mrps5|MRPS5]]|0.584|
|[[:human genes:m:mrps18a|MRPS18A]]|0.58|
|[[:human genes:m:mrps12|MRPS12]]|0.569|
|[[:human genes:m:mrps21|MRPS21]]|0.553|
|[[:human genes:m:mrps26|MRPS26]]|0.546|
|[[:human genes:c:coa3|COA3]]|0.544|
|[[:human genes:v:vars2|VARS2]]|0.541|
|[[:human genes:m:mrps6|MRPS6]]|0.538|
|[[:human genes:m:mrps35|MRPS35]]|0.535|
|[[:human genes:d:dap3|DAP3]]|0.533|
|[[:human genes:f:fars2|FARS2]]|0.53|
|[[:human genes:m:mrpl21|MRPL21]]|0.528|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.526|
|[[:human genes:r:rars2|RARS2]]|0.522|
|[[:human genes:n:nars2|NARS2]]|0.519|
|[[:human genes:q:qrsl1|QRSL1]]|0.519|
|[[:human genes:m:mrps16|MRPS16]]|0.518|
|[[:human genes:d:dars2|DARS2]]|0.514|
|[[:human genes:r:rpusd4|RPUSD4]]|0.513|
|[[:human genes:y:yars2|YARS2]]|0.513|
|[[:human genes:m:mrpl47|MRPL47]]|0.511|
|[[:human genes:e:ears2|EARS2]]|0.507|
|[[:human genes:s:selrc1|SELRC1]]|0.506|
|[[:human genes:m:mrps25|MRPS25]]|0.505|
|[[:human genes:m:mrpl3|MRPL3]]|0.503|
|[[:human genes:p:pars2|PARS2]]|0.502|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.501|
|[[:human genes:f:fastkd5|FASTKD5]]|0.5|
|[[:human genes:w:wbscr16|WBSCR16]]|0.499|
|[[:human genes:s:sco2|SCO2]]|0.499|
|[[:human genes:t:trub2|TRUB2]]|0.498|
|[[:human genes:g:gfm1|GFM1]]|0.497|
|[[:human genes:c:cox7b|COX7B]]|0.496|
|[[:human genes:c:cox16|COX16]]|0.495|
|[[:human genes:m:mrpl53|MRPL53]]|0.494|
|[[:human genes:m:mrpl44|MRPL44]]|0.485|
|[[:human genes:m:mrps34|MRPS34]]|0.484|
|[[:human genes:p:pet112|PET112]]|0.483|
|[[:human genes:m:mrps7|MRPS7]]|0.482|
|[[:human genes:s:sars2|SARS2]]|0.48|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.48|
|[[:human genes:m:mrp63|MRP63]]|0.479|
|[[:human genes:a:aars2|AARS2]]|0.479|
|[[:human genes:m:mars2|MARS2]]|0.478|
|[[:human genes:m:mrpl20|MRPL20]]|0.477|
|[[:human genes:m:mrps2|MRPS2]]|0.474|
|[[:human genes:m:mtg1|MTG1]]|0.474|
|[[:human genes:m:mrps22|MRPS22]]|0.473|
|[[:human genes:m:mrpl33|MRPL33]]|0.472|
|[[:human genes:h:hars2|HARS2]]|0.47|
|[[:human genes:p:pet117|PET117]]|0.47|
|[[:human genes:t:tars2|TARS2]]|0.469|
|[[:human genes:r:rbfa|RBFA]]|0.469|
|[[:human genes:b:bcs1l|BCS1L]]|0.469|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.468|
|[[:human genes:m:mrps24|MRPS24]]|0.468|
|[[:human genes:c:cox15|COX15]]|0.467|
|[[:human genes:c:cox17|COX17]]|0.466|
|[[:human genes:g:gatc|GATC]]|0.466|
|[[:human genes:m:mrps14|MRPS14]]|0.465|
|[[:human genes:c:cox6b1|COX6B1]]|0.459|
|[[:human genes:m:mrpl55|MRPL55]]|0.458|
|[[:human genes:f:ftsj2|FTSJ2]]|0.458|
|[[:human genes:m:mrpl45|MRPL45]]|0.457|
|[[:human genes:g:gfm2|GFM2]]|0.451|
|[[:human genes:p:pdss1|PDSS1]]|0.45|
|[[:human genes:m:mrpl2|MRPL2]]|0.449|
|[[:human genes:m:mettl17|METTL17]]|0.449|
|[[:human genes:m:mtpap|MTPAP]]|0.448|
|[[:human genes:m:mrpl17|MRPL17]]|0.447|
|[[:human genes:n:ndufb11|NDUFB11]]|0.446|
|[[:human genes:l:lars2|LARS2]]|0.445|
|[[:human genes:l:lrpprc|LRPPRC]]|0.444|
|[[:human genes:d:ddx28|DDX28]]|0.443|
|[[:human genes:m:mrpl12|MRPL12]]|0.443|
|[[:human genes:c:coq4|COQ4]]|0.442|
|[[:human genes:m:mrps10|MRPS10]]|0.435|
|[[:human genes:c:coa5|COA5]]|0.433|
|[[:human genes:m:mrps9|MRPS9]]|0.432|
|[[:human genes:m:mrpl49|MRPL49]]|0.431|
|[[:human genes:t:tufm|TUFM]]|0.431|
|[[:human genes:m:mrpl4|MRPL4]]|0.431|
|[[:human genes:e:eral1|ERAL1]]|0.43|
|[[:human genes:i:ict1|ICT1]]|0.427|
|[[:human genes:m:mcat|MCAT]]|0.426|
|[[:human genes:t:tefm|TEFM]]|0.424|
|[[:human genes:s:slc25a26|SLC25A26]]|0.424|
|[[:human genes:m:mrpl34|MRPL34]]|0.423|
|[[:human genes:i:iba57|IBA57]]|0.421|
|[[:human genes:n:ndufa3|NDUFA3]]|0.419|
|[[:human genes:u:uqcrc2|UQCRC2]]|0.419|
|[[:human genes:m:mrpl42|MRPL42]]|0.419|
|[[:human genes:c:coa6|COA6]]|0.418|
|[[:human genes:t:trmt10c|TRMT10C]]|0.417|
|[[:human genes:a:aifm1|AIFM1]]|0.416|
|[[:human genes:c:c10orf2|C10orf2]]|0.415|
|[[:human genes:r:rpusd3|RPUSD3]]|0.415|
|[[:human genes:m:mipep|MIPEP]]|0.415|
|[[:human genes:m:mrpl52|MRPL52]]|0.414|
|[[:human genes:c:cars2|CARS2]]|0.413|
|[[:human genes:c:cox11|COX11]]|0.407|
|[[:human genes:c:coq2|COQ2]]|0.407|
|[[:human genes:t:tomm20|TOMM20]]|0.407|
|[[:human genes:m:mrpl28|MRPL28]]|0.405|
|[[:human genes:g:gtpbp6|GTPBP6]]|0.405|
|[[:human genes:c:clpp|CLPP]]|0.405|
|[[:human genes:n:ndufa1|NDUFA1]]|0.404|
|[[:human genes:p:pnpt1|PNPT1]]|0.403|
|[[:human genes:h:hmgxb3|HMGXB3]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 143/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|2/28|
|blood|5/28|
|bone|2/26|
|breast|10/33|
|central nervous system|5/56|
|cervix|3/4|
|colorectal|7/17|
|esophagus|6/13|
|fibroblast|0/1|
|gastric|4/16|
|kidney|3/21|
|liver|5/20|
|lung|15/75|
|lymphocyte|2/16|
|ovary|1/26|
|pancreas|4/24|
|peripheral nervous system|2/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|5/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|5/22|
|urinary tract|6/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 270
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.74 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MRPL18 Expression in NALM6 Cells: 5.74'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>