======= MRPL34 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MRPL34
  * **<color #00a2e8>Official Name</color>**: mitochondrial ribosomal protein L34
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=64981|64981]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BQ48|Q9BQ48]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MRPL34&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MRPL34|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611840|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ribosomal L34|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrial ribosome|
|mitochondrial large ribosomal subunit|
|mitochondrial translational elongation|
|mitochondrial translational termination|
|translational termination|
|mitochondrial translation|
|translational elongation|
|cellular protein complex disassembly|
|mitochondrial gene expression|
|structural constituent of ribosome|
|protein-containing complex disassembly|
|translation|
|mitochondrial inner membrane|
|cellular component disassembly|
|peptide biosynthetic process|
|amide biosynthetic process|
|peptide metabolic process|
|cellular amide metabolic process|
|mitochondrion|
|organonitrogen compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp128|GSK591 2.6μM R03 exp128]]|1.86|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|2.06|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|2.07|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|2.08|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:y:yars2|YARS2]]|0.583|
|[[:human genes:s:sars2|SARS2]]|0.571|
|[[:human genes:t:tars2|TARS2]]|0.566|
|[[:human genes:m:mrpl23|MRPL23]]|0.563|
|[[:human genes:m:mrpl47|MRPL47]]|0.557|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.555|
|[[:human genes:m:mrps5|MRPS5]]|0.534|
|[[:human genes:m:mrps34|MRPS34]]|0.532|
|[[:human genes:t:tufm|TUFM]]|0.522|
|[[:human genes:f:fastkd5|FASTKD5]]|0.521|
|[[:human genes:r:rpusd4|RPUSD4]]|0.516|
|[[:human genes:m:mrpl53|MRPL53]]|0.509|
|[[:human genes:m:mrpl21|MRPL21]]|0.508|
|[[:human genes:m:mrpl15|MRPL15]]|0.506|
|[[:human genes:m:mrps6|MRPS6]]|0.505|
|[[:human genes:m:mrps21|MRPS21]]|0.504|
|[[:human genes:m:mrps14|MRPS14]]|0.501|
|[[:human genes:p:pars2|PARS2]]|0.5|
|[[:human genes:m:mrps2|MRPS2]]|0.497|
|[[:human genes:v:vars2|VARS2]]|0.496|
|[[:human genes:m:mrps24|MRPS24]]|0.493|
|[[:human genes:d:dap3|DAP3]]|0.493|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.492|
|[[:human genes:g:gatc|GATC]]|0.49|
|[[:human genes:m:mrps16|MRPS16]]|0.488|
|[[:human genes:s:sco2|SCO2]]|0.483|
|[[:human genes:m:mrp63|MRP63]]|0.482|
|[[:human genes:p:pnpt1|PNPT1]]|0.482|
|[[:human genes:m:mrps26|MRPS26]]|0.479|
|[[:human genes:m:mtg2|MTG2]]|0.479|
|[[:human genes:c:cox16|COX16]]|0.471|
|[[:human genes:m:mrps12|MRPS12]]|0.467|
|[[:human genes:s:selrc1|SELRC1]]|0.465|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.464|
|[[:human genes:d:dars2|DARS2]]|0.462|
|[[:human genes:m:mrps18a|MRPS18A]]|0.462|
|[[:human genes:m:mrps9|MRPS9]]|0.46|
|[[:human genes:m:mrps25|MRPS25]]|0.459|
|[[:human genes:m:mtpap|MTPAP]]|0.458|
|[[:human genes:a:atp5d|ATP5D]]|0.45|
|[[:human genes:n:ndufb11|NDUFB11]]|0.445|
|[[:human genes:r:rbfa|RBFA]]|0.444|
|[[:human genes:m:mrpl55|MRPL55]]|0.443|
|[[:human genes:t:trub2|TRUB2]]|0.442|
|[[:human genes:c:cox6c|COX6C]]|0.441|
|[[:human genes:c:coa3|COA3]]|0.441|
|[[:human genes:b:bcs1l|BCS1L]]|0.44|
|[[:human genes:t:tomm40|TOMM40]]|0.44|
|[[:human genes:e:elac2|ELAC2]]|0.439|
|[[:human genes:m:mrpl44|MRPL44]]|0.438|
|[[:human genes:g:gfm1|GFM1]]|0.438|
|[[:human genes:t:tefm|TEFM]]|0.437|
|[[:human genes:c:cox17|COX17]]|0.437|
|[[:human genes:p:pdss1|PDSS1]]|0.435|
|[[:human genes:n:ndufa3|NDUFA3]]|0.431|
|[[:human genes:c:coa5|COA5]]|0.431|
|[[:human genes:c:chchd4|CHCHD4]]|0.43|
|[[:human genes:m:mrpl12|MRPL12]]|0.429|
|[[:human genes:e:ears2|EARS2]]|0.429|
|[[:human genes:t:tmem126b|TMEM126B]]|0.428|
|[[:human genes:c:cox7b|COX7B]]|0.428|
|[[:human genes:c:c17orf89|C17orf89]]|0.427|
|[[:human genes:c:c10orf2|C10orf2]]|0.425|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.423|
|[[:human genes:m:mrpl18|MRPL18]]|0.423|
|[[:human genes:q:qrsl1|QRSL1]]|0.422|
|[[:human genes:m:mrpl3|MRPL3]]|0.421|
|[[:human genes:m:mars2|MARS2]]|0.421|
|[[:human genes:t:tomm20|TOMM20]]|0.421|
|[[:human genes:s:slc25a26|SLC25A26]]|0.42|
|[[:human genes:n:nars2|NARS2]]|0.415|
|[[:human genes:f:fars2|FARS2]]|0.414|
|[[:human genes:m:mrps11|MRPS11]]|0.411|
|[[:human genes:u:uqcrq|UQCRQ]]|0.41|
|[[:human genes:h:hars2|HARS2]]|0.409|
|[[:human genes:g:gfm2|GFM2]]|0.408|
|[[:human genes:w:wbscr16|WBSCR16]]|0.407|
|[[:human genes:c:c12orf65|C12orf65]]|0.406|
|[[:human genes:u:uqcr10|UQCR10]]|0.405|
|[[:human genes:m:mrpl11|MRPL11]]|0.404|
|[[:human genes:m:mrpl41|MRPL41]]|0.403|
|[[:human genes:t:triap1|TRIAP1]]|0.402|
|[[:human genes:m:mrps33|MRPS33]]|0.402|
|[[:human genes:m:mrpl42|MRPL42]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 57/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|3/28|
|blood|0/28|
|bone|0/26|
|breast|5/33|
|central nervous system|2/56|
|cervix|1/4|
|colorectal|2/17|
|esophagus|3/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|1/21|
|liver|1/20|
|lung|10/75|
|lymphocyte|3/16|
|ovary|1/26|
|pancreas|1/24|
|peripheral nervous system|1/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1199
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.01 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MRPL34 Expression in NALM6 Cells: 5.01'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>